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  1. Human rhinoviruses (HRV), the most frequent cause of respiratory infections, include 99 different serotypes segregating into two species, A and B. Rhinoviruses share extensive genomic sequence similarity with ...

    Authors: Caroline Tapparel, Thomas Junier, Daniel Gerlach, Samuel Cordey, Sandra Van Belle, Luc Perrin, Evgeny M Zdobnov and Laurent Kaiser
    Citation: BMC Genomics 2007 8:224
    Content type: Research article Published on:

  2. The out of Africa hypothesis has gained generalized consensus. However, many specific questions remain unsettled. To know whether the two M and N macrohaplogroups that colonized Eurasia were already present in...

    Authors: Ana M González, José M Larruga, Khaled K Abu-Amero, Yufei Shi, José Pestano and Vicente M Cabrera
    Citation: BMC Genomics 2007 8:223
    Content type: Research article Published on:

  4. Post-puberty deterioration of kidneys is more rapid in males than in females. To reveal the underlying molecular mechanisms for this difference, we analyzed gender-dependent gene expression in kidneys of three...

    Authors: Li Li, Susanne N Boehn, Xiaolei Yu, Qingqin Zhang, Marc Kenzelmann, Dieter Techel, Salah A Mohamed, Petra Jakob, Bettina Kraenzlin, Sigrid Hoffmann and Norbert Gretz
    Citation: BMC Genomics 2007 8:221
    Content type: Research article Published on:

  5. Bordetella bronchiseptica is a bacterial respiratory pathogen that infects a broad range of mammals, causing chronic and often subclinical infections. Gene expression in Bordetella is regulated by a two-component...

    Authors: Tracy L Nicholson
    Citation: BMC Genomics 2007 8:220
    Content type: Research article Published on:

  6. Three kinases: Sch9, PKA and TOR, are suggested to be involved in both the replicative and chronological ageing in yeast. They function in pathways whose down-regulation leads to life span extension. Several s...

    Authors: Chao Cheng, Paola Fabrizio, Huanying Ge, Valter D Longo and Lei M Li
    Citation: BMC Genomics 2007 8:219
    Content type: Methodology article Published on:

  8. Functional and comparative studies of insect genomes have shed light on the complement of genes, which in part, account for shared morphologies, developmental programs and life-histories. Contrasting the gene ...

    Authors: John K Colbourne, Brian D Eads, Joseph Shaw, Elizabeth Bohuski, Darren J Bauer and Justen Andrews
    Citation: BMC Genomics 2007 8:217
    Content type: Research article Published on:

  10. To gain insight into host-microbe interactions in a piglet model, a functional genomics approach was used to address the working hypothesis that transcriptionally regulated genes associated with promoting epit...

    Authors: Shankar R Chowdhury, Dale E King, Benjamin P Willing, Mark R Band, Jonathan E Beever, Adrienne B Lane, Juan J Loor, Juan C Marini, Laurie A Rund, Lawrence B Schook, Andrew G Van Kessel and H Rex Gaskins
    Citation: BMC Genomics 2007 8:215
    Content type: Research article Published on:

  11. Genetic influences underpinning complex traits are thought to involve multiple quantitative trait loci (QTLs) of small effect size. Detection of such QTL associations requires systematic screening of large num...

    Authors: Sophia J Docherty, Lee M Butcher, Leonard C Schalkwyk and Robert Plomin
    Citation: BMC Genomics 2007 8:214
    Content type: Methodology article Published on:

  12. In the Chlorophyta – the green algal phylum comprising the classes Prasinophyceae, Ulvophyceae, Trebouxiophyceae and Chlorophyceae – the chloroplast genome displays a highly variable architecture. While chloro...

    Authors: Jean-Charles de Cambiaire, Christian Otis, Monique Turmel and Claude Lemieux
    Citation: BMC Genomics 2007 8:213
    Content type: Research article Published on:

  13. Integrating plant genomics and classical breeding is a challenge for both plant breeders and molecular biologists. Marker-assisted selection (MAS) is a tool that can be used to accelerate the development of no...

    Authors: David Chagné, Charmaine M Carlisle, Céline Blond, Richard K Volz, Claire J Whitworth, Nnadozie C Oraguzie, Ross N Crowhurst, Andrew C Allan, Richard V Espley, Roger P Hellens and Susan E Gardiner
    Citation: BMC Genomics 2007 8:212
    Content type: Research article Published on:

  14. The recent discovery of widespread copy number variation in humans has forced a shift away from the assumption of two copies per locus per cell throughout the autosomal genome. In particular, a SNP site can no...

    Authors: Laura E MacConaill, Micheala A Aldred, Xincheng Lu and Thomas LaFramboise
    Citation: BMC Genomics 2007 8:211
    Content type: Research article Published on:

  15. The pluripotency and self-renewal capabilities, which define the "stemness" state, of mouse embryonic stem (ES) cells, are usually investigated by functional assays or quantitative measurements of the expressi...

    Authors: Daniel YL Yap, David K Smith, Xue W Zhang and Jeffrey Hill
    Citation: BMC Genomics 2007 8:210
    Content type: Methodology article Published on:

  16. To identify as many different transcripts/genes in the Atlantic salmon genome as possible, it is crucial to acquire good cDNA libraries from different tissues and developmental stages, their relevant sequences...

    Authors: Alexei A Adzhubei, Anna V Vlasova, Heidi Hagen-Larsen, Torgeir A Ruden, Jon K Laerdahl and Bjørn Høyheim
    Citation: BMC Genomics 2007 8:209
    Content type: Database Published on:

  17. Osteoporosis is frequently observed among aging hens from egg-producing strains (layers) of domestic chicken. White Leghorn (WL) has been intensively selected for egg production and it manifests striking pheno...

    Authors: Carl-Johan Rubin, Johan Lindberg, Carolyn Fitzsimmons, Peter Savolainen, Per Jensen, Joakim Lundeberg, Leif Andersson and Andreas Kindmark
    Citation: BMC Genomics 2007 8:208
    Content type: Research article Published on:

  18. The liver is the largest human internal organ – it is composed of multiple cell types and plays a vital role in fulfilling the body's metabolic needs and maintaining homeostasis. Of these cell types the hepato...

    Authors: Jian Huang, Pei Hao, Yun-Li Zhang, Fu-Xing Deng, Qing Deng, Yi Hong, Xiao-Wo Wang, Yun Wang, Ting-Ting Li, Xue-Gong Zhang, Yi-Xue Li, Peng-Yuan Yang, Hong-Yang Wang and Ze-Guang Han
    Citation: BMC Genomics 2007 8:207
    Content type: Research article Published on:

  19. Changes in genomic copy number occur in many human diseases including cancer. Characterization of these changes is important for both basic understanding and diagnosis of these diseases. Microarrays have recen...

    Authors: Kyoko Iwao-Koizumi, Kazunori Maekawa, Yohko Nakamura, Sakae Saito, Shoko Kawamoto, Akira Nakagawara and Kikuya Kato
    Citation: BMC Genomics 2007 8:206
    Content type: Methodology article Published on:

  20. Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation in children and adoles...

    Authors: Claudine G James, Veronica Ulici, Jan Tuckermann, T Michael Underhill and Frank Beier
    Citation: BMC Genomics 2007 8:205
    Content type: Research article Published on:

  21. Leptospirosis is a world-widely distributed zoonosis. Humans become infected via exposure to pathogenic Leptospira spp. from contaminated water or soil. The availability of genomic sequences of Leptospira interro...

    Authors: Ping He, Yue-Ying Sheng, Yao-Zhou Shi, Xiu-Gao Jiang, Jin-Hong Qin, Zhi-Ming Zhang, Guo-Ping Zhao and Xiao-Kui Guo
    Citation: BMC Genomics 2007 8:204
    Content type: Research article Published on:

  23. Honey bees are known for several striking social behaviors, including a complex pattern of behavioral maturation that gives rise to an age-related colony division of labor and a symbolic dance language, by whi...

    Authors: Moushumi Sen Sarma, Charles W Whitfield and Gene E Robinson
    Citation: BMC Genomics 2007 8:202
    Content type: Research article Published on:

  24. The Fox gene family comprises a large and functionally diverse group of forkhead-related transcriptional regulators, many of which are essential for metazoan embryogenesis and physiology. Defining conserved funct...

    Authors: Sergey Yaklichkin, Alexander Vekker, Steven Stayrook, Mitchell Lewis and Daniel S Kessler
    Citation: BMC Genomics 2007 8:201
    Content type: Research article Published on:

  28. In the post-genomic era, comprehension of cellular processes and systems requires global and non-targeted approaches to handle vast amounts of biological information.

    Authors: Hirokazu Kobayashi, Joe Akitomi, Nobuyuki Fujii, Kazuo Kobayashi, Md Altaf-Ul-Amin, Ken Kurokawa, Naotake Ogasawara and Shigehiko Kanaya
    Citation: BMC Genomics 2007 8:197
    Content type: Research article Published on:

  29. Bulked segregant analysis (BSA) identifies molecular markers associated with a phenotype by screening two DNA pools of phenotypically distinct plants for markers with skewed allele frequencies. In contrast to ...

    Authors: Peter Wenzl, Harsh Raman, Junping Wang, Meixue Zhou, Eric Huttner and Andrzej Kilian
    Citation: BMC Genomics 2007 8:196
    Content type: Methodology article Published on:

  30. The zebrafish (Danio rerio) is an important vertebrate model organism system for biomedical research. The syntenic conservation between the zebrafish and human genome allows one to investigate the function of hum...

    Authors: Jennifer L Freeman, Adeola Adeniyi, Ruby Banerjee, Stephanie Dallaire, Sean F Maguire, Jianxiang Chi, Bee Ling Ng, Cinthya Zepeda, Carol E Scott, Sean Humphray, Jane Rogers, Yi Zhou, Leonard I Zon, Nigel P Carter, Fengtang Yang and Charles Lee
    Citation: BMC Genomics 2007 8:195
    Content type: Research article Published on:

  31. Mammalian angiotensin converting enzyme (ACE) plays a key role in blood pressure regulation. Although multiple ACE-like proteins exist in non-mammalian organisms, to date only one other ACE homologue, ACE2, ha...

    Authors: Monika Rella, Joann L Elliot, Timothy J Revett, Jerry Lanfear, Anne Phelan, Richard M Jackson, Anthony J Turner and Nigel M Hooper
    Citation: BMC Genomics 2007 8:194
    Content type: Research article Published on:

  32. Excessive accumulation of lipids in the adipose tissue is a major problem in the present-day broiler industry. However, few studies have analyzed the expression of adipose tissue genes that are involved in pat...

    Authors: Hong-Bao Wang, Hui Li, Qi-Gui Wang, Xin-Yu Zhang, Shou-Zhi Wang, Yu-Xiang Wang and Xiu-Ping Wang
    Citation: BMC Genomics 2007 8:193
    Content type: Research article Published on:

  33. This study assesses the whole-genome gene expression changes in a panel of primary human cell lines in response to DNA damage mediated by decay of DNA-incorporated radioiodinated thymidine analog 5-[125I]iodo-2'-...

    Authors: Mykyta V Sokolov, Ronald D Neumann and Igor G Panyutin
    Citation: BMC Genomics 2007 8:192
    Content type: Research article Published on:

  34. The carboxy termini of proteins are a frequent site of activity for a variety of biologically important functions, ranging from post-translational modification to protein targeting. Several short peptide motif...

    Authors: Ryan S Austin, Nicholas J Provart and Sean R Cutler
    Citation: BMC Genomics 2007 8:191
    Content type: Research article Published on:

  35. The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug developm...

    Authors: Nicole A Datson, Maarten C Morsink, Srebrena Atanasova, Victor W Armstrong, Hans Zischler, Christina Schlumbohm, Bas E Dutilh, Martijn A Huynen, Brigitte Waegele, Andreas Ruepp, E Ronald de Kloet and Eberhard Fuchs
    Citation: BMC Genomics 2007 8:190
    Content type: Research article Published on:

  36. Cholangiocarcinoma (CCA) – cancer of the bile ducts – is associated with chronic infection with the liver fluke, Opisthorchis viverrini. Despite being the only eukaryote that is designated as a 'class I carcinoge...

    Authors: Thewarach Laha, Porntip Pinlaor, Jason Mulvenna, Banchob Sripa, Manop Sripa, Michael J Smout, Robin B Gasser, Paul J Brindley and Alex Loukas
    Citation: BMC Genomics 2007 8:189
    Content type: Research article Published on:

  37. Microarray gene expression (MAGE) signatures allow insights into the transcriptional processes of leukemias and may evolve as a molecular diagnostic test. Introduction of MAGE into clinical practice of leukemi...

    Authors: Marta Campo Dell'Orto, Andrea Zangrando, Luca Trentin, Rui Li, Wei-min Liu, Geertruy te Kronnie, Giuseppe Basso and Alexander Kohlmann
    Citation: BMC Genomics 2007 8:188
    Content type: Methodology article Published on:

  38. Berries of grape (Vitis vinifera) contain three major tissue types (skin, pulp and seed) all of which contribute to the aroma, color, and flavor characters of wine. The pericarp, which is composed of the exocarp ...

    Authors: Jerome Grimplet, Laurent G Deluc, Richard L Tillett, Matthew D Wheatley, Karen A Schlauch, Grant R Cramer and John C Cushman
    Citation: BMC Genomics 2007 8:187
    Content type: Research article Published on:

  39. Five species of the genus Schistosoma, a parasitic trematode flatworm, are causative agents of Schistosomiasis, a disease that is endemic in a large number of developing countries, affecting millions of patien...

    Authors: Elida PB Ojopi, Paulo SL Oliveira, Diana N Nunes, Apuã Paquola, Ricardo DeMarco, Sheila P Gregório, Karina A Aires, Carlos FM Menck, Luciana CC Leite, Sergio Verjovski-Almeida and Emmanuel Dias-Neto
    Citation: BMC Genomics 2007 8:186
    Content type: Research article Published on:

  40. Cancer arises from the consecutive acquisition of genetic alterations. Increasing evidence suggests that as a consequence of these alterations, molecular interactions are reprogrammed in the context of highly ...

    Authors: Pilar Hernández, Jaime Huerta-Cepas, David Montaner, Fátima Al-Shahrour, Joan Valls, Laia Gómez, Gabriel Capellá, Joaquín Dopazo and Miguel Angel Pujana
    Citation: BMC Genomics 2007 8:185
    Content type: Research article Published on:

  41. The human gastric pathogen Helicobacter pylori is co-evolved with its host and therefore, origins and expansion of multiple populations and sub populations of H. pylori mirror ancient human migrations. Ancestral ...

    Authors: S Manjulata Devi, Irshad Ahmed, Paolo Francalacci, M Abid Hussain, Yusuf Akhter, Ayesha Alvi, Leonardo A Sechi, Francis Mégraud and Niyaz Ahmed
    Citation: BMC Genomics 2007 8:184
    Content type: Research article Published on:

  42. Many studies have found segregating quantitative trait loci (QTL) for milk production traits in different dairy cattle populations. However, even for relatively large effects with a saturated marker map the co...

    Authors: Micha Ron, Galit Israeli, Eyal Seroussi, Joel I Weller, Jeffrey P Gregg, Moshe Shani and Juan F Medrano
    Citation: BMC Genomics 2007 8:183
    Content type: Research article Published on:

  43. The annotated genomes of two closely related strains of the intracellular bacterium Wolbachia pipientis have been reported without the identifications of the putative origin of replication (ori). Identifying the

    Authors: Panagiotis Ioannidis, Julie C Dunning Hotopp, Panagiotis Sapountzis, Stefanos Siozios, Georgios Tsiamis, Seth R Bordenstein, Laura Baldo, John H Werren and Kostas Bourtzis
    Citation: BMC Genomics 2007 8:182
    Content type: Research article Published on:

  44. The parasitic trematode Schistosoma mansoni is one of the major causative agents of Schistosomiasis, a disease that affects approximately 200 million people, mostly in developing countries. Since much of the path...

    Authors: Michael Waisberg, Francisco P Lobo, Gustavo C Cerqueira, Liana KJ Passos, Omar S Carvalho, Glória R Franco and Najib M El-Sayed
    Citation: BMC Genomics 2007 8:181
    Content type: Research article Published on:

  45. Groundwater and subsurface environments contaminated with aromatic compounds can be remediated in situ by Geobacter species that couple oxidation of these compounds to reduction of Fe(III)-oxides. Geobacter metal...

    Authors: Jessica E Butler, Qiang He, Kelly P Nevin, Zhili He, Jizhong Zhou and Derek R Lovley
    Citation: BMC Genomics 2007 8:180
    Content type: Research article Published on:

  46. It has become evident that host cells react to recombinant protein production with a variety of metabolic and intrinsic stresses such as the unfolded protein response (UPR) pathway. Additionally, environmental...

    Authors: Brigitte Gasser, Michael Maurer, Jari Rautio, Michael Sauer, Anamitra Bhattacharyya, Markku Saloheimo, Merja Penttilä and Diethard Mattanovich
    Citation: BMC Genomics 2007 8:179
    Content type: Research article Published on:

  47. Cotton, as an allopolyploid species, contains homoeologous A and D subgenomes. The study of the homoeologous (duplicated) segments or chromosomes can facilitate insight into the evolutionary process of polyplo...

    Authors: Kai Wang, Wangzhen Guo and Tianzhen Zhang
    Citation: BMC Genomics 2007 8:178
    Content type: Research article Published on:

  48. EST sequencing is one of the most efficient means for gene discovery and molecular marker development, and can be additionally utilized in both comparative genome analysis and evaluation of gene duplications. ...

    Authors: Ping Li, Eric Peatman, Shaolin Wang, Jinian Feng, Chongbo He, Puttharat Baoprasertkul, Peng Xu, Huseyin Kucuktas, Samiran Nandi, Benjaporn Somridhivej, Jerry Serapion, Micah Simmons, Cemal Turan, Lei Liu, William Muir, Rex Dunham…
    Citation: BMC Genomics 2007 8:177
    Content type: Research article Published on:

  49. The ciliate protozoan Ichthyophthirius multifiliis (Ich) is an important parasite of freshwater fish that causes 'white spot disease' leading to significant losses. A genomic resource for large-scale studies of t...

    Authors: Jason W Abernathy, Peng Xu, Ping Li, De-Hai Xu, Huseyin Kucuktas, Phillip Klesius, Covadonga Arias and Zhanjiang Liu
    Citation: BMC Genomics 2007 8:176
    Content type: Research article Published on:

  50. Plants respond to low temperature through an intricately coordinated transcriptional network. The CBF/DREB-regulated network of genes has been shown to play a prominent role in freeze-tolerance of Arabidopsis thr...

    Authors: Chen Cheng, Kil-Young Yun, Habtom W Ressom, Bijayalaxmi Mohanty, Vladimir B Bajic, Yulin Jia, Song Joong Yun and Benildo G de los Reyes
    Citation: BMC Genomics 2007 8:175
    Content type: Research article Published on:

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BMC Genomics

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