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  1. We have previously identified associations between major histocompatibility complex (MHC) class I and resistance towards bacterial and viral pathogens in Atlantic salmon. To evaluate if only MHC or also closel...

    Authors: Morten F Lukacs, Håvard Harstad, Unni Grimholt, Marianne Beetz-Sargent, Glenn A Cooper, Linda Reid, Hege G Bakke, Ruth B Phillips, Kristina M Miller, William S Davidson and Ben F Koop
    Citation: BMC Genomics 2007 8:251
  2. The sequencing of the D.melanogaster genome revealed an unexpected small number of genes (~ 14,000) indicating that mechanisms acting on generation of transcript diversity must have played a major role in the evo...

    Authors: Rafaela M Maia, Valeria Valente, Marco AV Cunha, Josane F Sousa, Daniela D Araujo, Wilson A Silva Jr, Marco A Zago, Emmanuel Dias-Neto, Sandro J Souza, Andrew JG Simpson, Nadia Monesi, Ricardo GP Ramos, Enilza M Espreafico and Maria L Paçó-Larson
    Citation: BMC Genomics 2007 8:249
  3. The completion and reporting of baculovirus genomes is extremely important as it advances our understanding of gene function and evolution. Due to the large number of viral genomes now sequenced it is very imp...

    Authors: Zuo-Ming Nie, Zhi-Fang Zhang, Dan Wang, Ping-An He, Cai-Ying Jiang, Li Song, Fang Chen, Jie Xu, Ling Yang, Lin-Lin Yu, Jian Chen, Zheng-Bing Lv, Jing-Jing Lu, Xiang-Fu Wu and Yao-Zhou Zhang
    Citation: BMC Genomics 2007 8:248
  4. Folate synthesis and salvage pathways are relatively well known from classical biochemistry and genetics but they have not been subjected to comparative genomic analysis. The availability of genome sequences f...

    Authors: Valérie de Crécy-Lagard, Basma El Yacoubi, Rocío Díaz de la Garza, Alexandre Noiriel and Andrew D Hanson
    Citation: BMC Genomics 2007 8:245
  5. Within the last decade a large number of noncoding RNA genes have been identified, but this may only be the tip of the iceberg. Using comparative genomics a large number of sequences that have signals concorda...

    Authors: Christian Weile, Paul P Gardner, Mads M Hedegaard and Jeppe Vinther
    Citation: BMC Genomics 2007 8:244
  6. MADS-box transcription factors, besides being involved in floral organ specification, have also been implicated in several aspects of plant growth and development. In recent years, there have been reports on g...

    Authors: Rita Arora, Pinky Agarwal, Swatismita Ray, Ashok Kumar Singh, Vijay Pal Singh, Akhilesh K Tyagi and Sanjay Kapoor
    Citation: BMC Genomics 2007 8:242
  7. The family Camelidae that evolved in North America during the Eocene survived with two distinct tribes, Camelini and Lamini. To investigate the evolutionary relationship between them and to further understand ...

    Authors: Peng Cui, Rimutu Ji, Feng Ding, Dan Qi, Hongwei Gao, He Meng, Jun Yu, Songnian Hu and Heping Zhang
    Citation: BMC Genomics 2007 8:241
  8. At present, nothing is known of the role of miRNAs in the immune response in vivo despite the fact that inflammation is thought to underlie multiple acute and chronic diseases. In these circumstances, patients ar...

    Authors: Sterghios A Moschos, Andrew E Williams, Mark M Perry, Mark A Birrell, Maria G Belvisi and Mark A Lindsay
    Citation: BMC Genomics 2007 8:240
  9. Transcriptional profiling after herbivore attack reveals, at the molecular level, how plants respond to this type of biotic stress. Comparing herbivore-induced transcriptional responses of plants with differen...

    Authors: Colette Broekgaarden, Erik H Poelman, Greet Steenhuis, Roeland E Voorrips, Marcel Dicke and Ben Vosman
    Citation: BMC Genomics 2007 8:239
  10. Studies of association methods using DNA pooling of single nucleotide polymorphisms (SNPs) have focused primarily on the effects of "machine-error", number of replicates, and the size of the pool. We use the n...

    Authors: Fei Ji, Stephen J Finch, Chad Haynes, Nancy R Mendell and Derek Gordon
    Citation: BMC Genomics 2007 8:238
  11. Abdominal aortic aneurysms are a common disorder with an incompletely understood etiology. We used Illumina and Affymetrix microarray platforms to generate global gene expression profiles for both aneurysmal (...

    Authors: Guy M Lenk, Gerard Tromp, Shantel Weinsheimer, Zoran Gatalica, Ramon Berguer and Helena Kuivaniemi
    Citation: BMC Genomics 2007 8:237
  12. Mutations in the human polycystic kidney disease-1 (hPKD1) gene result in ~85% of cases of autosomal dominant polycystic kidney disease, the most frequent human monogenic disease. PKD1 proteins are large multidom...

    Authors: H Jayantha Gunaratne, Gary W Moy, Masashi Kinukawa, Shinji Miyata, Silvia A Mah and Victor D Vacquier
    Citation: BMC Genomics 2007 8:235
  13. In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at...

    Authors: O Clyde Hutchinson, Kim Picozzi, Nicola G Jones, Helen Mott, Reuben Sharma, Susan C Welburn and Mark Carrington
    Citation: BMC Genomics 2007 8:234
  14. The CSL (C BF1/RBP-Jκ/S uppressor of Hairless/L AG-1) transcription factor family members are well-known components of the transmembrane receptor Notch signaling pathway, which plays a critical role in metazoan d...

    Authors: Martin Převorovský, František Půta and Petr Folk
    Citation: BMC Genomics 2007 8:233
  15. In situ hybridization (ISH) is a powerful method for visualizing gene expression patterns at the organismal level with cellular resolution. When automated, it is capable of determining the expression of a large n...

    Authors: Murat Cankaya, Ana Martinez Hernandez, Mehmet Ciftci, Sukru Beydemir, Hasan Ozdemir, Harun Budak, Ilhami Gulcin, Veysel Comakli, Tufan Emircupani, Deniz Ekinci, Muslum Kuzu, Qiuhong Jiang, Gregor Eichele and Omer Irfan Kufrevioglu
    Citation: BMC Genomics 2007 8:232
  16. Phylogenetic and functional analysis was conducted on an Anopheles gambiae gene, ENSANGG00000017398. Based on phylogenetic analysis, this gene belongs to the same lineage as Heat shock protein cognate 70-4 (Hsc70...

    Authors: Cheolho Sim, Young S Hong, Konstantin A Tsetsarkin, Dana L Vanlandingham, Stephen Higgs and Frank H Collins
    Citation: BMC Genomics 2007 8:231
  17. Human natural killer (NK) cells are the key contributors of innate immune response and the effector functions of these cells are enhanced by cytokines such as interleukine 2 (IL2). We utilized genome-wide tran...

    Authors: Karen Dybkaer, Javeed Iqbal, Guimei Zhou, Huimin Geng, Li Xiao, Alexander Schmitz, Francesco d'Amore and Wing C Chan
    Citation: BMC Genomics 2007 8:230
  18. The genomes of Streptomyces coelicolor and Streptomyces lividans bear a considerable degree of synteny. While S. coelicolor is the model streptomycete for studying antibiotic synthesis and differentiation, S. liv...

    Authors: Karthik P Jayapal, Wei Lian, Frank Glod, David H Sherman and Wei-Shou Hu
    Citation: BMC Genomics 2007 8:229
  19. Fabaceae (legumes) is one of the largest families of flowering plants, and some members are important crops. In contrast to what we know about their great diversity or economic importance, our knowledge at the...

    Authors: Xianwu Guo, Santiago Castillo-Ramírez, Víctor González, Patricia Bustos, José Luís Fernández-Vázquez, Rosa Isela Santamaría, Jesús Arellano, Miguel A Cevallos and Guillermo Dávila
    Citation: BMC Genomics 2007 8:228
  20. Voltage-gated Na+ channel β1 (Scn1b) subunits are multi-functional proteins that play roles in current modulation, channel cell surface expression, cell adhesion, cell migration, and neurite outgrowth. We have sh...

    Authors: Amanda J Fein, Laurence S Meadows, Chunling Chen, Emily A Slat and Lori L Isom
    Citation: BMC Genomics 2007 8:226
  21. Human rhinoviruses (HRV), the most frequent cause of respiratory infections, include 99 different serotypes segregating into two species, A and B. Rhinoviruses share extensive genomic sequence similarity with ...

    Authors: Caroline Tapparel, Thomas Junier, Daniel Gerlach, Samuel Cordey, Sandra Van Belle, Luc Perrin, Evgeny M Zdobnov and Laurent Kaiser
    Citation: BMC Genomics 2007 8:224
  22. The out of Africa hypothesis has gained generalized consensus. However, many specific questions remain unsettled. To know whether the two M and N macrohaplogroups that colonized Eurasia were already present in...

    Authors: Ana M González, José M Larruga, Khaled K Abu-Amero, Yufei Shi, José Pestano and Vicente M Cabrera
    Citation: BMC Genomics 2007 8:223
  23. Post-puberty deterioration of kidneys is more rapid in males than in females. To reveal the underlying molecular mechanisms for this difference, we analyzed gender-dependent gene expression in kidneys of three...

    Authors: Li Li, Susanne N Boehn, Xiaolei Yu, Qingqin Zhang, Marc Kenzelmann, Dieter Techel, Salah A Mohamed, Petra Jakob, Bettina Kraenzlin, Sigrid Hoffmann and Norbert Gretz
    Citation: BMC Genomics 2007 8:221
  24. Bordetella bronchiseptica is a bacterial respiratory pathogen that infects a broad range of mammals, causing chronic and often subclinical infections. Gene expression in Bordetella is regulated by a two-component...

    Authors: Tracy L Nicholson
    Citation: BMC Genomics 2007 8:220
  25. Three kinases: Sch9, PKA and TOR, are suggested to be involved in both the replicative and chronological ageing in yeast. They function in pathways whose down-regulation leads to life span extension. Several s...

    Authors: Chao Cheng, Paola Fabrizio, Huanying Ge, Valter D Longo and Lei M Li
    Citation: BMC Genomics 2007 8:219
  26. Functional and comparative studies of insect genomes have shed light on the complement of genes, which in part, account for shared morphologies, developmental programs and life-histories. Contrasting the gene ...

    Authors: John K Colbourne, Brian D Eads, Joseph Shaw, Elizabeth Bohuski, Darren J Bauer and Justen Andrews
    Citation: BMC Genomics 2007 8:217
  27. To gain insight into host-microbe interactions in a piglet model, a functional genomics approach was used to address the working hypothesis that transcriptionally regulated genes associated with promoting epit...

    Authors: Shankar R Chowdhury, Dale E King, Benjamin P Willing, Mark R Band, Jonathan E Beever, Adrienne B Lane, Juan J Loor, Juan C Marini, Laurie A Rund, Lawrence B Schook, Andrew G Van Kessel and H Rex Gaskins
    Citation: BMC Genomics 2007 8:215
  28. Genetic influences underpinning complex traits are thought to involve multiple quantitative trait loci (QTLs) of small effect size. Detection of such QTL associations requires systematic screening of large num...

    Authors: Sophia J Docherty, Lee M Butcher, Leonard C Schalkwyk and Robert Plomin
    Citation: BMC Genomics 2007 8:214
  29. In the Chlorophyta – the green algal phylum comprising the classes Prasinophyceae, Ulvophyceae, Trebouxiophyceae and Chlorophyceae – the chloroplast genome displays a highly variable architecture. While chloro...

    Authors: Jean-Charles de Cambiaire, Christian Otis, Monique Turmel and Claude Lemieux
    Citation: BMC Genomics 2007 8:213
  30. Integrating plant genomics and classical breeding is a challenge for both plant breeders and molecular biologists. Marker-assisted selection (MAS) is a tool that can be used to accelerate the development of no...

    Authors: David Chagné, Charmaine M Carlisle, Céline Blond, Richard K Volz, Claire J Whitworth, Nnadozie C Oraguzie, Ross N Crowhurst, Andrew C Allan, Richard V Espley, Roger P Hellens and Susan E Gardiner
    Citation: BMC Genomics 2007 8:212
  31. The recent discovery of widespread copy number variation in humans has forced a shift away from the assumption of two copies per locus per cell throughout the autosomal genome. In particular, a SNP site can no...

    Authors: Laura E MacConaill, Micheala A Aldred, Xincheng Lu and Thomas LaFramboise
    Citation: BMC Genomics 2007 8:211
  32. The pluripotency and self-renewal capabilities, which define the "stemness" state, of mouse embryonic stem (ES) cells, are usually investigated by functional assays or quantitative measurements of the expressi...

    Authors: Daniel YL Yap, David K Smith, Xue W Zhang and Jeffrey Hill
    Citation: BMC Genomics 2007 8:210
  33. To identify as many different transcripts/genes in the Atlantic salmon genome as possible, it is crucial to acquire good cDNA libraries from different tissues and developmental stages, their relevant sequences...

    Authors: Alexei A Adzhubei, Anna V Vlasova, Heidi Hagen-Larsen, Torgeir A Ruden, Jon K Laerdahl and Bjørn Høyheim
    Citation: BMC Genomics 2007 8:209
  34. Osteoporosis is frequently observed among aging hens from egg-producing strains (layers) of domestic chicken. White Leghorn (WL) has been intensively selected for egg production and it manifests striking pheno...

    Authors: Carl-Johan Rubin, Johan Lindberg, Carolyn Fitzsimmons, Peter Savolainen, Per Jensen, Joakim Lundeberg, Leif Andersson and Andreas Kindmark
    Citation: BMC Genomics 2007 8:208
  35. The liver is the largest human internal organ – it is composed of multiple cell types and plays a vital role in fulfilling the body's metabolic needs and maintaining homeostasis. Of these cell types the hepato...

    Authors: Jian Huang, Pei Hao, Yun-Li Zhang, Fu-Xing Deng, Qing Deng, Yi Hong, Xiao-Wo Wang, Yun Wang, Ting-Ting Li, Xue-Gong Zhang, Yi-Xue Li, Peng-Yuan Yang, Hong-Yang Wang and Ze-Guang Han
    Citation: BMC Genomics 2007 8:207
  36. Changes in genomic copy number occur in many human diseases including cancer. Characterization of these changes is important for both basic understanding and diagnosis of these diseases. Microarrays have recen...

    Authors: Kyoko Iwao-Koizumi, Kazunori Maekawa, Yohko Nakamura, Sakae Saito, Shoko Kawamoto, Akira Nakagawara and Kikuya Kato
    Citation: BMC Genomics 2007 8:206
  37. Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation in children and adoles...

    Authors: Claudine G James, Veronica Ulici, Jan Tuckermann, T Michael Underhill and Frank Beier
    Citation: BMC Genomics 2007 8:205
  38. Leptospirosis is a world-widely distributed zoonosis. Humans become infected via exposure to pathogenic Leptospira spp. from contaminated water or soil. The availability of genomic sequences of Leptospira interro...

    Authors: Ping He, Yue-Ying Sheng, Yao-Zhou Shi, Xiu-Gao Jiang, Jin-Hong Qin, Zhi-Ming Zhang, Guo-Ping Zhao and Xiao-Kui Guo
    Citation: BMC Genomics 2007 8:204

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