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  1. Many approaches have been used to study the evolution, population structure and genetic diversity of Escherichia coli O157:H7; however, observations made with different genotyping systems are not easily relatable...

    Authors: Chad R Laing, Cody Buchanan, Eduardo N Taboada, Yongxiang Zhang, Mohamed A Karmali, James E Thomas and Victor PJ Gannon
    Citation: BMC Genomics 2009 10:287
    Content type: Research article Published on:

  3. Manduca sexta, Heliothis virescens, and Heliconius erato represent three widely-used insect model species for genomic and fundamental studies in Lepidoptera. Large-insert BAC libraries of these insects are critic...

    Authors: Chengcang Wu, Dina Proestou, Dorothy Carter, Erica Nicholson, Filippe Santos, Shaying Zhao, Hong-Bin Zhang and Marian R Goldsmith
    Citation: BMC Genomics 2009 10:283
    Content type: Research article Published on:

  4. Sand fly saliva plays an important role in blood feeding and Leishmania transmission as it was shown to increase parasite virulence. On the other hand, immunity to salivary components impedes the establishment of...

    Authors: Jitka Hostomská, Věra Volfová, Jianbing Mu, Mark Garfield, Iva Rohoušová, Petr Volf, Jesus G Valenzuela and Ryan C Jochim
    Citation: BMC Genomics 2009 10:282
    Content type: Research article Published on:

  6. The expression levels of many genes show wide natural variation among strains or populations. This study investigated the potential for animal strain-related genotypic differences to confound gene expression p...

    Authors: Katherine J Deans, Peter C Minneci, Hao Chen, Steven J Kern, Carolea Logun, Sara Alsaaty, Kelly J Norsworthy, Stephanie M Theel, Joel D Sennesh, Jennifer J Barb, Peter J Munson, Robert L Danner and Michael A Solomon
    Citation: BMC Genomics 2009 10:280
    Content type: Research article Published on:

  7. Water stress during grain filling has a marked effect on grain yield, leading to a reduced endosperm cell number and thus sink capacity to accumulate dry matter. The bread wheat cultivar Chinese Spring (CS), a...

    Authors: Alessio Aprile, Anna M Mastrangelo, Anna M De Leonardis, Gabor Galiba, Enrica Roncaglia, Francesco Ferrari, Luigi De Bellis, Luana Turchi, Giovanni Giuliano and Luigi Cattivelli
    Citation: BMC Genomics 2009 10:279
    Content type: Research article Published on:

  9. Advances in the high-throughput omic technologies have made it possible to profile cells in a large number of ways at the DNA, RNA, protein, chromosomal, functional, and pharmacological levels. A persistent pr...

    Authors: Uma T Shankavaram, Sudhir Varma, David Kane, Margot Sunshine, Krishna K Chary, William C Reinhold, Yves Pommier and John N Weinstein
    Citation: BMC Genomics 2009 10:277
    Content type: Database Published on:

  10. Meta-analysis of QTLs combines the results of several QTL detection studies and provides narrow confidence intervals for meta-QTLs, permitting easier positional candidate gene identification. It is usually app...

    Authors: Farkhanda S Khowaja, Gareth J Norton, Brigitte Courtois and Adam H Price
    Citation: BMC Genomics 2009 10:276
    Content type: Research article Published on:

  11. Seven-transmembrane region-containing receptors (7TMRs) play central roles in eukaryotic signal transduction. Due to their biomedical importance, thorough mining of 7TMRs from diverse genomes has been an activ...

    Authors: Guoqing Lu, Zhifang Wang, Alan M Jones and Etsuko N Moriyama
    Citation: BMC Genomics 2009 10:275
    Content type: Database Published on:

  13. Microarray technology helped to accumulate an immense pool of data on gene expression changes in response to different environmental factors. Yet, computer- generated gene profiling using expressed sequence ta...

    Authors: Alexander M Boutanaev, Olga A Postnikova and Lev G Nemchinov
    Citation: BMC Genomics 2009 10:273
    Content type: Research article Published on:

  15. Wheat is an allopolyploid plant that harbors a huge, complex genome. Therefore, accumulation of expressed sequence tags (ESTs) for wheat is becoming particularly important for functional genomics and molecular...

    Authors: Kanako Kawaura, Keiichi Mochida, Akiko Enju, Yasushi Totoki, Atsushi Toyoda, Yoshiyuki Sakaki, Chikatoshi Kai, Jun Kawai, Yoshihide Hayashizaki, Motoaki Seki, Kazuo Shinozaki and Yasunari Ogihara
    Citation: BMC Genomics 2009 10:271
    Content type: Research article Published on:

  16. Plasmodium sporozoites migrate to the liver where they traverse several hepatocytes before invading the one inside which they will develop and multiply into thousands of merozoites. Although this constitutes an e...

    Authors: Sónia S Albuquerque, Céline Carret, Ana Rita Grosso, Alice S Tarun, Xinxia Peng, Stefan HI Kappe, Miguel Prudêncio and Maria M Mota
    Citation: BMC Genomics 2009 10:270
    Content type: Research article Published on:

  17. Housekeeping genes (HKG) are constitutively expressed in all tissues while tissue-enriched genes (TEG) are expressed at a much higher level in a single tissue type than in others. HKGs serve as valuable experi...

    Authors: Xinwei She, Carol A Rohl, John C Castle, Amit V Kulkarni, Jason M Johnson and Ronghua Chen
    Citation: BMC Genomics 2009 10:269
    Content type: Research article Published on:

  18. Metagenomic sequence data are proving to be a vast resource for the discovery of biological components. Yet analysis of this data to identify functional RNAs lags behind efforts to characterize protein diversi...

    Authors: Michelle M Meyer, Tyler D Ames, Daniel P Smith, Zasha Weinberg, Michael S Schwalbach, Stephen J Giovannoni and Ronald R Breaker
    Citation: BMC Genomics 2009 10:268
    Content type: Research article Published on:

  19. Filarial nematode parasites cause serious diseases such as elephantiasis and river blindness in humans, and heartworm infections in dogs. Third stage filarial larvae (L3) are a critical stage in the life cycle...

    Authors: Ben-Wen Li, Amy C Rush, Makedonka Mitreva, Yong Yin, David Spiro, Elodie Ghedin and Gary J Weil
    Citation: BMC Genomics 2009 10:267
    Content type: Research article Published on:

  20. The deleterious effect of a mutation can be reverted by a second-site interacting residue. This is an epistatic compensatory process explaining why mutations that are deleterious in some species are tolerated ...

    Authors: Luísa Azevedo, João Carneiro, Barbara van Asch, Ana Moleirinho, Filipe Pereira and António Amorim
    Citation: BMC Genomics 2009 10:266
    Content type: Research article Published on:

  21. Transcriptome expression analysis in peanut to date has been limited to a relatively small set of genes and only recently has a significant number of ESTs been released into the public domain. Utilization of t...

    Authors: Paxton Payton, Kameswara Rao Kottapalli, Diane Rowland, Wilson Faircloth, Baozhu Guo, Mark Burow, Naveen Puppala and Maria Gallo
    Citation: BMC Genomics 2009 10:265
    Content type: Research article Published on:

  22. Transcriptome sequencing using next-generation sequencing platforms will soon be competing with DNA microarray technologies for global gene expression analysis. As a preliminary evaluation of these promising t...

    Authors: Shrinivasrao P Mane, Clive Evans, Kristal L Cooper, Oswald R Crasta, Otto Folkerts, Stephen K Hutchison, Timothy T Harkins, Danielle Thierry-Mieg, Jean Thierry-Mieg and Roderick V Jensen
    Citation: BMC Genomics 2009 10:264
    Content type: Research article Published on:

  24. Among deuterostomes, the regenerative potential is maximally expressed in echinoderms, animals that can quickly replace most injured organs. In particular, sea cucumbers are excellent models for studying organ...

    Authors: Pablo A Ortiz-Pineda, Francisco Ramírez-Gómez, Judit Pérez-Ortiz, Sebastián González-Díaz, Francisco Santiago-De Jesús, Josue Hernández-Pasos, Cristina Del Valle-Avila, Carmencita Rojas-Cartagena, Edna C Suárez-Castillo, Karen Tossas, Ana T Méndez-Merced, José L Roig-López, Humberto Ortiz-Zuazaga and José E García-Arrarás
    Citation: BMC Genomics 2009 10:262
    Content type: Research article Published on:

  25. The molecular mechanisms of cell cycle exit are poorly understood. Studies on lymphocytes at cell cycle exit after growth factor deprivation have predominantly focused on the initiation of apoptosis. We aimed ...

    Authors: Magdalena Chechlinska, Jan Konrad Siwicki, Monika Gos, Malgorzata Oczko-Wojciechowska, Michal Jarzab, Aleksandra Pfeifer, Barbara Jarzab and Jan Steffen
    Citation: BMC Genomics 2009 10:261
    Content type: Research article Published on:

  26. Clostridium perfringens (Cp) is a Gram-positive anaerobic bacterium that causes necrotic enteritis (NE) in poultry when it overgrows in the small intestine. NE disease has previously been controlled through the u...

    Authors: Aimie J Sarson, Ying Wang, Zhumei Kang, Scot E Dowd, Yang Lu, Hai Yu, Yanming Han, Huaijun Zhou and Joshua Gong
    Citation: BMC Genomics 2009 10:260
    Content type: Research article Published on:

  27. Homology-based comparisons of the genes involved in innate immunity across many insect taxa with fully sequenced genomes has revealed a striking pattern of gene gain and loss, particularly among genes that enc...

    Authors: Timothy B Sackton and Andrew G Clark
    Citation: BMC Genomics 2009 10:259
    Content type: Research article Published on:

  28. The most diverse marine ecosystems, coral reefs, depend upon a functional symbiosis between cnidarian hosts and unicellular dinoflagellate algae. The molecular mechanisms underlying the establishment, maintena...

    Authors: Shinichi Sunagawa, Emily C Wilson, Michael Thaler, Marc L Smith, Carlo Caruso, John R Pringle, Virginia M Weis, Mónica Medina and Jodi A Schwarz
    Citation: BMC Genomics 2009 10:258
    Content type: Research article Published on:

  29. The mosquito Anopheles gambiae is a major vector of human malaria. Increasing evidence indicates that blood cells (hemocytes) comprise an essential arm of the mosquito innate immune response against both bacteria...

    Authors: Luke A Baton, Anne Robertson, Emma Warr, Michael R Strand and George Dimopoulos
    Citation: BMC Genomics 2009 10:257
    Content type: Research article Published on:

  30. In species with exalbuminous seeds, the endosperm is eventually consumed and its space occupied by the embryo during seed development. However, the main constituent of the early developing seed is the liquid e...

    Authors: Yi Huang, Liang Chen, Liping Wang, Kannan Vijayan, Sieu Phan, Ziying Liu, Lianglu Wan, Andrew Ross, Daoquan Xiang, Raju Datla, Youlian Pan and Jitao Zou
    Citation: BMC Genomics 2009 10:256
    Content type: Research article Published on:

  31. In contrast to the essentially fully assembled genome sequences of the kinetoplastid pathogens Leishmania major and Trypanosoma brucei the assembly of the Trypanosoma cruzi genome has been hindered by its repetit...

    Authors: D Brent Weatherly, Courtney Boehlke and Rick L Tarleton
    Citation: BMC Genomics 2009 10:255
    Content type: Research article Published on:

  33. Natural antisense transcripts (NATs) are transcripts of the opposite DNA strand to the sense-strand either at the same locus (cis-encoded) or a different locus (trans-encoded). They can affect gene expression at ...

    Authors: Tristan E Coram, Matthew L Settles and Xianming Chen
    Citation: BMC Genomics 2009 10:253
    Content type: Research article Published on:

  34. The requirements for growth and survival of the intracellular pathogen Trypanosoma cruzi within mammalian host cells are poorly understood. Transcriptional profiling of the host cell response to infection serves ...

    Authors: Jaime A Costales, Johanna P Daily and Barbara A Burleigh
    Citation: BMC Genomics 2009 10:252
    Content type: Research article Published on:

  35. Wheat (Triticum aestivum L.) is a staple food crop worldwide. The wheat genome has not yet been sequenced due to its huge genome size (~17,000 Mb) and high levels of repetitive sequences; the whole genome sequenc...

    Authors: Amy N Bernardo, Peter J Bradbury, Hongxiang Ma, Shengwa Hu, Robert L Bowden, Edward S Buckler and Guihua Bai
    Citation: BMC Genomics 2009 10:251
    Content type: Research article Published on:

  36. The subtelomeric regions of human chromosomes exhibit an extraordinary plasticity. To date, due to the high GC content and to the presence of telomeric repeats, the subtelomeric sequences are underrepresented ...

    Authors: Valerio Costa, Amelia Casamassimi, Roberta Roberto, Fernando Gianfrancesco, Maria R Matarazzo, Michele D'Urso, Maurizio D'Esposito, Mariano Rocchi and Alfredo Ciccodicola
    Citation: BMC Genomics 2009 10:250
    Content type: Research article Published on:

  37. The ability to localise or follow endogenous proteins in real time in vivo is of tremendous utility for cell biology or systems biology studies. Protein trap screens utilise the random genomic insertion of a tran...

    Authors: Jelena Aleksic, Ranko Lazic, Ilka Müller, Steven R Russell and Boris Adryan
    Citation: BMC Genomics 2009 10:249
    Content type: Methodology article Published on:

  38. We have performed Quantitative Trait Loci (QTL) analysis of an F2 intercross between two chicken lines divergently selected for juvenile body-weight. In a previous study 13 identified loci with effects on body-we...

    Authors: Per Wahlberg, Örjan Carlborg, Mario Foglio, Xavier Tordoir, Ann-Christine Syvänen, Mark Lathrop, Ivo G Gut, Paul B Siegel and Leif Andersson
    Citation: BMC Genomics 2009 10:248
    Content type: Research article Published on:

  39. Genetic analyses are often limited by the availability of appropriate molecular markers. Markers from neutrally evolving genomic regions may be particularly useful for inferring evolutionary histories because ...

    Authors: Zuogang Peng, Navin Elango, Derek E Wildman and Soojin V Yi
    Citation: BMC Genomics 2009 10:247
    Content type: Methodology article Published on:

  40. For more than a decade, microarrays have been a powerful and widely used tool to explore the transcriptome of biological systems. However, the amount of biological material from cell sorting or laser capture m...

    Authors: Mathieu Clément-Ziza, David Gentien, Stanislas Lyonnet, Jean-Paul Thiery, Claude Besmond and Charles Decraene
    Citation: BMC Genomics 2009 10:246
    Content type: Methodology article Published on:

  41. Two-component signal transduction systems (TCSTs), consisting of a histidine kinase (HK) and a response regulator (RR), represent a major paradigm for signal transduction in prokaryotes. TCSTs play critical ro...

    Authors: Youfu Zhao, Dongping Wang, Sridevi Nakka, George W Sundin and Schuyler S Korban
    Citation: BMC Genomics 2009 10:245
    Content type: Research article Published on:

  43. Expressed sequence tag (EST) databases represent a valuable resource for the identification of genes in organisms with uncharacterized genomes and for development of molecular markers. One class of markers der...

    Authors: Maria Domenica Moccia, Christine Oger-Desfeux, Gabriel AB Marais and Alex Widmer
    Citation: BMC Genomics 2009 10:243
    Content type: Research article Published on:

  45. The human zinc finger protein 191 (ZNF191) is a member of the SCAN domain family of Krüppel-like zinc finger transcription factors. ZNF191 shows 94% identity to its mouse homologue zinc finger protein 191(Zfp1...

    Authors: Jianzhong Li, Xia Chen, Xuelian Gong, Ying Liu, Hao Feng, Lei Qiu, Zhenlin Hu and Junping Zhang
    Citation: BMC Genomics 2009 10:241
    Content type: Research article Published on:

  46. We have recently identified two large families of extinct transposable elements termed Short Interspersed DEgenerated Retroposons (SIDERs) in the parasitic protozoan Leishmania major. The characterization of SIDE...

    Authors: Martin Smith, Frédéric Bringaud and Barbara Papadopoulou
    Citation: BMC Genomics 2009 10:240
    Content type: Research article Published on:

  47. Chlamydia trachomatis is the most common cause of sexually transmitted infections globally and the leading cause of preventable blindness in the developing world. There are two biovariants of C. trachomatis: 'tra...

    Authors: Helena MB Seth-Smith, Simon R Harris, Kenneth Persson, Pete Marsh, Andrew Barron, Alexandra Bignell, Carina Bjartling, Louise Clark, Lesley T Cutcliffe, Paul R Lambden, Nicola Lennard, Sarah J Lockey, Michael A Quail, Omar Salim, Rachel J Skilton, Yibing Wang…
    Citation: BMC Genomics 2009 10:239
    Content type: Research article Published on:

  48. Dermatophytes are fungi that cause superficial infections of the skin, hair, and nails. They are the most common agents of fungal infections worldwide. Dermatophytic fungi constitute three genera, Trichophyton, E...

    Authors: Yuan Wu, Jian Yang, Fan Yang, Tao Liu, Wenchuan Leng, Yonglie Chu and Qi Jin
    Citation: BMC Genomics 2009 10:238
    Content type: Research article Published on:

  50. Polycyclic aromatic hydrocarbons are common pollutants in soil, have negative effects on soil ecosystems, and are potentially carcinogenic. The Springtail (Collembola) Folsomia candida is often used as an indicat...

    Authors: Benjamin Nota, Mirte Bosse, Bauke Ylstra, Nico M van Straalen and Dick Roelofs
    Citation: BMC Genomics 2009 10:236
    Content type: Research article Published on:

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BMC Genomics

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