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  3. Transformation-associated recombination (TAR) cloning in yeast is a unique method for selective isolation of large chromosomal fragments or entire genes from complex genomes. The technique involves homologous ...

    Authors: Vladimir N Noskov, Natalay Kouprina, Sun-Hee Leem, Ilia Ouspenski, J Carl Barrett and Vladimir Larionov
    Citation: BMC Genomics 2003 4:16
    Content type: Methodology article Published on:

  4. Chromosomal abnormalities affecting human chromosome 15q11-q13 underlie multiple genomic disorders caused by deletion, duplication and triplication of intervals in this region. These events are mediated by hig...

    Authors: James S Sutcliffe, Michael K Han, Taneem Amin, Robert A Kesterson and Erika L Nurmi
    Citation: BMC Genomics 2003 4:15
    Content type: Research article Published on:

  6. HMG-box proteins are a large and diverse superfamily of architectural factors that share one or more copies of a sequence- and structurally-related DNA binding domain. These proteins can modify chromatin struc...

    Authors: Emmett O'Flaherty and Jonathan Kaye
    Citation: BMC Genomics 2003 4:13
    Content type: Research article Published on:

  7. For most sequenced prokaryotic genomes, about a third of the protein coding genes annotated are "orphan proteins", that is, they lack homology to known proteins. These hypothetical genes are typically short an...

    Authors: Lars Juhl Jensen, Marie Skovgaard, Thomas Sicheritz-Pontén, Merete Kjær Jørgensen, Christiane Lundegaard, Corinna Cavan Pedersen, Nanna Petersen and David Ussery
    Citation: BMC Genomics 2003 4:12
    Content type: Research article Published on:

  8. A limiting factor of cDNA microarray technology is the need for a substantial amount of RNA per labeling reaction. Thus, 20–200 micro-grams total RNA or 0.5–2 micro-grams poly (A) RNA is typically required for...

    Authors: Vigdis Nygaard, Anders Løland, Marit Holden, Mette Langaas, Håvard Rue, Fang Liu, Ola Myklebost, Øystein Fodstad, Eivind Hovig and Birgitte Smith-Sørensen
    Citation: BMC Genomics 2003 4:11
    Content type: Research article Published on:

  10. Chromosome band 10q24 is a gene-rich domain and host to a number of cancer, developmental, and neurological genes. Recurring translocations, deletions and mutations involving this chromosome band have been obs...

    Authors: Sheryl M Gough, Margaret McDonald, Xiao-Ning Chen, Julie R Korenberg, Antonino Neri, Tomas Kahn, Michael R Eccles and Christine M Morris
    Citation: BMC Genomics 2003 4:9
    Content type: Research article Published on:

  11. Microarray profiling has the potential to illuminate the molecular processes that govern the phenotypic characteristics of porcine skeletal muscles, such as hypertrophy or atrophy, and the expression of specif...

    Authors: Qianfan Bai, Christine McGillivray, Nuno da Costa, Saffron Dornan, Gary Evans, Michael James Stear and Kin-Chow Chang
    Citation: BMC Genomics 2003 4:8
    Content type: Research article Published on:

  12. Differential polyadenylation is a widespread mechanism in higher eukaryotes producing mRNAs with different 3' ends in different contexts. This involves several alternative polyadenylation sites in the 3' UTR, ...

    Authors: Matthieu Legendre and Daniel Gautheret
    Citation: BMC Genomics 2003 4:7
    Content type: Research article Published on:

  13. Short tandem repeat polymorphisms (STRPs) are powerful tools for gene mapping and other applications. A STRP genome scan of 10 cM is usually adequate for mapping single gene disorders. However mapping studies ...

    Authors: Nader Ghebranious, David Vaske, Adong Yu, Chengfeng Zhao, Gabor Marth and James L Weber
    Citation: BMC Genomics 2003 4:6
    Content type: Research article Published on:

  15. Low RNA yields from small tissue samples can limit the use of oligonucleotide microarrays (Affymetrix GeneChips®). Methods using less cRNA for hybridization or amplifying the cRNA have been reported to reduce the...

    Authors: Jeanette N McClintick, Ronald E Jerome, Charles R Nicholson, David W Crabb and Howard J Edenberg
    Citation: BMC Genomics 2003 4:4
    Content type: Research article Published on:

  16. The vertebrate opsins are proteins which utilise a retinaldehyde chromophore in their photosensory or photoisomerase roles in the visual/irradiance detection cycle. The majority of the opsins, such as rod and ...

    Authors: James Bellingham, Dominic J Wells and Russell G Foster
    Citation: BMC Genomics 2003 4:3
    Content type: Research article Published on:

  17. Tagged sequence mutagenesis is a process for constructing libraries of sequenced insertion mutations in embryonic stem cells that can be transmitted into the mouse germline. To better predict the functional co...

    Authors: Michael Roshon, James V DeGregori and H Earl Ruley
    Citation: BMC Genomics 2003 4:2
    Content type: Research article Published on:

  18. Methylation at CpG dinucleotides in genomic DNA is a fundamental epigenetic mechanism of gene expression control in vertebrates. Proteins with a methyl-CpG-binding domain (MBD) can bind to single methylated Cp...

    Authors: Tim C Roloff, H Hilger Ropers and Ulrike A Nuber
    Citation: BMC Genomics 2003 4:1
    Content type: Research article Published on:

  19. In order to contribute to the establishment of a complete map of transcribed regions of the human genome, we constructed a testicular cDNA library for the cynomolgus monkey, and attempted to find novel transcr...

    Authors: Naoki Osada, Munetomo Hida, Jun Kusuda, Reiko Tanuma, Makoto Hirata, Yumiko Suto, Momoki Hirai, Keiji Terao, Sumio Sugano and Katsuyuki Hashimoto
    Citation: BMC Genomics 2002 3:36
    Content type: Research article Published on:

  21. Complete sequencing and annotation of the 96.2 kb Bacillus anthracis plasmid, pXO2, predicted 85 open reading frames (ORFs). Bacillus cereus and Bacillus thuringiensis isolates that ranged in genomic similarity t...

    Authors: James Pannucci, Richard T Okinaka, Erin Williams, Robert Sabin, Lawrence O Ticknor and Cheryl R Kuske
    Citation: BMC Genomics 2002 3:34
    Content type: Research article Published on:

  22. The CyaB protein from Aeromonas hydrophila has been shown to possess adenylyl cyclase activity. While orthologs of this enzyme have been found in some bacteria and archaea, it shows no detectable relationship to ...

    Authors: Lakshminarayan M Iyer and L Aravind
    Citation: BMC Genomics 2002 3:33
    Content type: Research article Published on:

  23. Co-regulation of genes may imply involvement in similar biological processes or related function. Many clusters of co-regulated genes have been identified using microarray experiments. In this study, we examin...

    Authors: Wei Ding, Luquan Wang, Ping Qiu, Mitchel Kostich, Jonathan Greene and Marco Hernandez
    Citation: BMC Genomics 2002 3:32
    Content type: Research article Published on:

  24. T7 based linear amplification of RNA is used to obtain sufficient antisense RNA for microarray expression profiling. We optimized and systematically evaluated the fidelity and reproducibility of different ampl...

    Authors: Hongjuan Zhao, Trevor Hastie, Michael L Whitfield, Anne-Lise Børresen-Dale and Stefanie S Jeffrey
    Citation: BMC Genomics 2002 3:31
    Content type: Methodology article Published on:

  25. Multiple candidate regions as sites for Schizophrenia and Bipolar susceptibility genes have been reported, suggesting heterogeneity of susceptibility genes or oligogenic inheritance. Linkage analysis has sugge...

    Authors: Manjula Maheshwari, SL Christian, C Liu, JA Badner, S Detera-Wadleigh, ES Gershon and Richard A Gibbs
    Citation: BMC Genomics 2002 3:30
    Content type: Research article Published on:

  26. The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-expressed genes using EST database, and its application to I...

    Authors: Lawrence Benbow, Lynn Wang, Maureen Laverty, Suxing Liu, Ping Qiu, Richard W Bond, Eric Gustafson, Joseph A Hedrick, Mitchell Kostich, Jonathan R Greene and Luquan Wang
    Citation: BMC Genomics 2002 3:29
    Content type: Research article Published on:

  27. Microarray technology is a powerful methodology for identifying differentially expressed genes. However, when thousands of genes in a microarray data set are evaluated simultaneously by fold changes and signif...

    Authors: Yuanyuan Xiao, Mark R Segal, Douglas Rabert, Andrew H Ahn, Praveen Anand, Lakshmi Sangameswaran, Donglei Hu and C Anthony Hunt
    Citation: BMC Genomics 2002 3:28
    Content type: Research article Published on:

  30. Gonadotropin releasing hormone (GnRH) is responsible for stimulation of gonadotropic hormone (GtH) in the hypothalamus-pituitary-gonadal axis (HPG). The regulatory mechanisms responsible for brain specificity ...

    Authors: Jacob Torgersen, Rasoul Nourizadeh-Lillabadi, Harald Husebye and Peter Aleström
    Citation: BMC Genomics 2002 3:25
    Content type: Research article Published on:

  31. The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order o...

    Authors: Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams and Gerard Tromp
    Citation: BMC Genomics 2002 3:24
    Content type: Research article Published on:

  32. The dinucleotide relative abundance profile can be regarded as a genomic signature because, despite diversity between species, it varies little between 50 kilobase or longer windows on a given genome. Both the...

    Authors: Robert W Jernigan and Robert H Baran
    Citation: BMC Genomics 2002 3:23
    Content type: Research article Published on:

  33. Analysis of cell-selective gene expression for families of proteins of therapeutic interest is crucial when deducing the influence of genes upon complex traits and disease susceptibility. Presently, there is n...

    Authors: Grant Dewson, Edward C Conley and Peter Bradding
    Citation: BMC Genomics 2002 3:22
    Content type: Methodology article Published on:

  38. Based on sequence similarity, the superfamily of G protein-coupled receptors (GPRs) can be subdivided into several subfamilies, the members of which often share similar ligands. The sequence data provided by t...

    Authors: Timo Wittenberger, Susanne Hellebrand, Antonia Munck, Hans-Jürgen Kreienkamp, H Chica Schaller and Wolfgang Hampe
    Citation: BMC Genomics 2002 3:17
    Content type: Research article Published on:

  39. High density cDNA microarray technology provides a powerful tool to survey the activity of thousands of genes in normal and diseased cells, which helps us both to understand the molecular basis of the disease ...

    Authors: Limei Hu, Jing Wang, Keith Baggerly, Hua Wang, Gregory N Fuller, Stanley R Hamilton, Kevin R Coombes and Wei Zhang
    Citation: BMC Genomics 2002 3:16
    Content type: Methodology article Published on:

  40. Freshwater planarians are widely used as models for investigation of pattern formation and studies on genetic variation in populations. Despite extensive information on the biology and genetics of planaria, th...

    Authors: Denis V Rebrikov, Maria E Bulina, Ekaterina A Bogdanova, Loura L Vagner and Sergey A Lukyanov
    Citation: BMC Genomics 2002 3:15
    Content type: Research article Published on:

  43. Suppression Subtractive Hybridization PCR (SSH PCR) is a sophisticated cDNA subtraction method to enrich and isolate differentially expressed genes. Despite its popularity, the method has not been thoroughly s...

    Authors: Wan Ji, Matthew B Wright, Li Cai, Angel Flament and Klaus Lindpaintner
    Citation: BMC Genomics 2002 3:12
    Content type: Research article Published on:

  44. The centromere is a specialized locus that mediates chromosome movement during mitosis and meiosis. This chromosomal domain comprises a uniquely packaged form of heterochromatin that acts as a nucleus for the ...

    Authors: Javier Figueroa, Carlos Pendón and Manuel M Valdivia
    Citation: BMC Genomics 2002 3:11
    Content type: Research article Published on:

  45. Genome wide transcriptome maps can provide tools to identify candidate genes that are over-expressed or silenced in certain disease tissue and increase our understanding of the structure and organization of th...

    Authors: Ping Qiu, Lawrence Benbow, Suxing Liu, Jonathan R Greene and Luquan Wang
    Citation: BMC Genomics 2002 3:10
    Content type: Research article Published on:

  46. Animal and yeast proteins containing long coiled-coil domains are involved in attaching other proteins to the large, solid-state components of the cell. One subgroup of long coiled-coil proteins are the nuclea...

    Authors: Frank Gindullis, Annkatrin Rose, Shalaka Patel and Iris Meier
    Citation: BMC Genomics 2002 3:9
    Content type: Research article Published on:

  47. The DNA single-strand annealing proteins (SSAPs), such as RecT, Redβ, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. Recently, they have been shown to form similar h...

    Authors: Lakshminarayan M Iyer, Eugene V Koonin and L Aravind
    Citation: BMC Genomics 2002 3:8
    Content type: Research article Published on:

  48. Gene expression profiling among different tissues is of paramount interest in various areas of biomedical research. We have developed a novel method (DADA, D igital A nalysis of cD NA A bundance), that calculates...

    Authors: Peter Hof, Claudia Ortmeier, Kirstin Pape, Birgit Reitmaier, Johannes Regenbogen, Andreas Goppelt and Joern-Peter Halle
    Citation: BMC Genomics 2002 3:7
    Content type: Methodology article Published on:

  49. Familial atrial fibrillation, an autosomal dominant disease, was previously mapped to chromosome 10q22. One of the genes mapped to the 10q22 region is DLG5, a member of the MAGUKs (Membrane Associated Gyanylat...

    Authors: Gopi Shah, Ramon Brugada, Oscar Gonzalez, Grazyna Czernuszewicz, Richard A Gibbs, Linda Bachinski and Robert Roberts
    Citation: BMC Genomics 2002 3:6
    Content type: Research article Published on:

  50. Inhibitor of Apoptosis (IAP) proteins are key intrinsic regulators of apoptosis induced by a variety of triggers. We isolated the rat Inhibitor of Apoptosis genes 1, 2 and 3 and characterized their tissue dist...

    Authors: Martin Holcik, Charles A Lefebvre, Keiko Hicks and Robert G Korneluk
    Citation: BMC Genomics 2002 3:5
    Content type: Research article Published on:

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BMC Genomics

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