Figure 5From: Age-related molecular genetic changes of murine bone marrow mesenchymal stem cellsAge-related Decline of Alkaline phosphatase (AP) activity. Osteogenic differentiation involves increased secretion of AP. Alkaline phosphataes was measured in the media of differentiating cell at day 10 as described in Methods. Significantly less AP was secreted from cells taken from mice at age 26 mo (n=4; p<0.01).Back to article page