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Table 2 Genes downregulated by Tax (fold change ≥ 2.0, p < 0.05)

From: Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis

Gene symbol

Gene description

Gene ID

Fold change

 

Transcription/Translation/RNA processing

  

ANP32A

Cerebellar leucine rich acidic nuclear protein (LANP)

8125

2.0

EID1

EP300 interacting inhibitor of differentiation 1

23741

2.0

PAIP1

poly(A) binding protein interacting protein 1

10605

2.0

RBM4

RNA binding motif protein 4

5936

2.0

SFRS7

splicing factor, arginine/serine-rich 7, 35 kDa

6432

2.0

SR140

U2-associated SR140 protein

23350

2.0

BCLAF1

BCL2-associated transcription factor 1

9774

2.1

IMPACT

Impact homolog (mouse)

55364

2.3

LSM5

LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)

23658

2.3

MRPS14

mitochondrial ribosomal protein S14

63931

2.3

SUB1

SUB1 homolog (S. cerevisiae)

10923

2.3

ZNF623

zinc finger protein 623

9831

2.3

BRIP1

BRCA1 interacting protein C-terminal helicase 1

83990

2.4

TTF2

transcription termination factor, RNA polymerase II

8458

2.6

 

Signal transduction

  

PDE1A

phosphodiesterase 1A, calmodulin-dependent

5136

2.0

PDE3A

phosphodiesterase 3A, cGMP-inhibited

5139

2.0

PRKCI

protein kinase C, iota

5584

2.1

SRI

sorcin

6717

2.8

 

Immune response/Response to virus

  

DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

23586

2.2

IFI44

interferon-induced protein 44

10561

2.2

DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

55601

3.0

IFIT3

interferon-induced protein with tetratricopeptide repeats 3

3437

4.1

IFIT2

interferon-induced protein with tetratricopeptide repeats 2

3433

4.4

IFIT1

interferon-induced protein with tetratricopeptide repeats 1

3434

6.0

OASL

2'-5'-oligoadenylate synthetase-like

8638

6.4

 

Apoptosis

  

CARD10

caspase recruitment domain family, member 10

29775

2.0

BCLAF1

BCL2-associated transcription factor 1

9774

2.1

 

Cell cycle

  

MAD2L1

MAD2 mitotic arrest deficient-like 1 (yeast)

4085

2.0

KIF11

kinesin family member 11

3832

2.1

NF2

neurofibromin 2 (merlin)

4771

2.1

SEP11

septin 11

55752

2.1

CENPF

centromere protein F, 350/400 ka (mitosin)

1063

2.5

 

Regulation of cell proliferation

  

BMP2

bone morphogenetic protein 2

650

2.2

DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

1601

2.4

FGF2

fibroblast growth factor 2 (basic)

2247

3.4

 

Cell signaling

  

PCSK1

proprotein convertase subtilisin/kexin type 1

5122

4.8

 

Cell adhesion

  

CD24

CD24 molecule

100133941

2.3

PKP2

plakophilin 2

5318

2.3

COL14A1

collagen, type XIV, alpha 1

7373

2.5

 

Nucleosome assembly

  

H2AFV

H2A histone family, member V

94239

2.0

 

Transport

  

CNGB1

cyclic nucleotide gated channel beta 1

1258

2.0

SCNN1A

sodium channel, nonvoltage-gated 1 alpha

6337

2.0

ANO2

anoctamin 2

57101

2.1

CHRNA9

cholinergic receptor, nicotinic, alpha 9

55584

2.2

SORBS1

sorbin and SH3 domain containing 1

10580

2.3

STEAP4

STEAP family member 4

79689

2.3

SRI

sorcin

6717

2.6

 

Metabolic process

  

ACSL4

acyl-CoA synthetase long-chain family member 4

2182

2.0

 

Ubiquitin

  

FBXO3

F-box protein 3

26273

2.0

HERC6

hect domain and RLD 6

55008

2.1

DZIP3

DAZ interacting protein 3, zinc finger

9666

2.3

HERC5

hect domain and RLD 5

51191

4.8

 

Others/Unknown

  

NIP7

nuclear import 7 homolog (S. cerevisiae)

51388

2.0

PPL

periplakin

5493

2.0

ADK

adenosine kinase

132

2.1

DIO2

deiodinase, iodothyronine, type II

1734

2.1

PICALM

phosphatidylinositol binding clathrin assembly protein

8301

2.1

METAP2

methionyl aminopeptidase 2

10988

2.2

HIP1R

huntingtin interacting protein 1 related

9026

2.3

ERAP1

KIAA0525 protein

51752

2.4

DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

1601

2.5

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BMC Genomics

ISSN: 1471-2164

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