gene clusters for nonribosomal peptide and polyketide biosynthesis. Genes encoding nonribosomal peptide synthases are depicted in dark blue, type I polyketide synthases in red and type II polyketide synthases in orange. The genes involved in the synthesis of putative precursors are highlighted in light green. The remaining genes of the clusters are presented in pale blue. All genes involved in the biosynthesis of an enediyne core in cluster 6 are framed brown. aao, l-amino-acid oxidase; abc, ABC transporter; acc, acyl-CoA carboxylase; acd, acyl-CoA dehydrogenase; acp, acyl carrier protein; acs, acyl-CoA synthetase; act, acyl-CoA transferase; amo, amine oxidase; amt, aminotransferase; ap, aminopeptidase; ask, adenylylsulfate kinase; asl, AMP-dependent synthetase and ligase; ass, sulfate adenylyltransferase; at, acyl transferase; bh, beta-hydroxylase; cbs, carbamoyltransferase; cd, cysteine desulfurase; cho, cholesterol oxidase; cl, chlorinating protein; clf, chain length factor; ct, carboxyltransferase; cys, cysteine synthase; dbp, DNA-binding protein; dc, decarboxylase; dgb, glyoxalase/bleomycin resistance protein/dioxygenase; dh, dehydratase; dhbas, protein involved in the synthesis of activated 2,3-dihydroxybenzoic acid; dhg, dehydrogenase; e/l, esterase/lipase; eci, enoyl-CoA hydratase/isomerase; eff, efflux protein; gsit, glutamine—scyllo-inositol transaminase; gt, glycosyltransferase; hal, histidine ammonia-lyase; hmacps, protein involved in the synthesis of hydroxymalonyl-ACP; hmbppr, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; hmg, hydroxymethylglutaryl-CoA synthase; hpah, 4-hydroxyphenylacetate-3-hydroxylase; hyd, hydrolase; int, integrase; kr, ketoreductase; ks II, FabF-like protein; ks III, FabH-like protein; lam, lysine 2,3-aminomutase like protein; llp, lipolytic protein; lys, protein involved in lysine synthesis via alpha-aminoadipate; mfs, transporter of the major facilitator superfamily; mmcd, methylmalonyl-CoA decarboxylase; mo, monooxygenase; mt, methyltransferase; mtr, methionyl-tRNA synthetase; npd, 2-nitropropane dioxygenase; ocd, ornithine cyclodeaminase; oxy, oxidoreductase; p450, cytochrome P450; phas, polyhydroxy alkanoic acid synthase; pkc, polyketide cyclase; ppph, 2-polyprenylphenol 6-hydroxylase; pro, protease; reg, regulatory protein; rsam, radical SAM protein; sarp, streptomyces antibiotic regulatory protein; sip, siderophore-interacting protein; tcd, taurine catabolism dioxygenase; te, thioesterase; tetr, protein similar to the tetracycline repressor; tk, transketolase; tn, transposase.