Figure 2

Interval maps for immune response phenotypes in male, female and combined male and female cohorts. QTL for male (blue line) and female (red line) as compared to both sexes together (broken black line) for (A) worm burden (Ch4), (B) IFN-γ, (C) TNF-α, (D) IL-6 (all Ch5) response phenotypes. (E) Overlap of male QTL for INF-γ (red line), TNF-α (green line) and IL-6 (blue line). Upper dark line on maps show significant LRS scores whilst lower lines show suggestive LRS scores.