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Figure 6 | BMC Genomics

Figure 6

From: Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures – linking genome-wide transcriptional changes to cellular physiology

Figure 6

Distribution of selected gene probes among physiological function categories. Gene probes were chosen using the 60 % data availability criteria and disregarding recovery phase changes for diamide and H2O2. Part A. Functional distribution of gene probes (1986 in total; Additional file 3:Supplement3 for the list of gene probes considered in significant enrichment calculations) considered in significant enrichment calculations (Figure 7). Parts B-G. Distribution of gene probes as a function of physiological function categories as well as stress-inducing agents (Parts B-D) and oxidative stress-responsive physiological parameters (Parts E-G). For these analyses, gene probes influenced by treatments (Parts B-D) or responsive to changes in physiological parameters (Parts E-G) were selected; n values stand for the gene probes involved in separate functional distribution analyses. Gene probes equally responsive to dimide, H2O2, menadione treatments, or to H2O2 and menadione but not to diamide or solely responsive to menadione were regarded as GSH/GSSG, O22- or O2•--responsive, respectively. Segments of the diagrams represent the following physiological function categories: I, "Function-unknown"; II, "Signal generation and transduction, DNA transcription, regulation"; III, "Replication, cell division cycle and development"; IV, "RNA splicing and translation, protein maturation"; V, "Defense and stress proteins, degradation of xenobiotics; VI, "Transport, cytoskeleton, cell wall"; VII, "Carbon metabolism"; VIII, "Nitrogen and sulfur metabolism"; IX, "Secondary metabolism"; X, "Oxidoreductases".

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