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Table 4 Gene Ontology analysis: unfused compared to fused sutures

From: Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis

Biological process increased in sutures:

Unfused

Fused

P-value

Cell adhesion

32

 

1.95 × 10-12

   Cell matrix adhesion

4

 

6.53 × 10-3

Cell communication

   

   Cell surface receptor linked signal transduction

25

 

4.45 × 10-3

   Dopamine metabolism

2

 

6.63 × 10-4

   Phosphoinsitide-mediated signalling

 

8

4.58 × 10-3

Cell differentiation

   

   Heme biosynthesis

 

3

6.96 × 10-3

   Lymphocyte differentiation

 

6

1.27 × 10-3

Cellular physiological process

   

   Anion transport

11

 

4.92 × 10-6

   Cell cycle

 

42

4.72 × 10-5

   Cell motility

11

 

2.70 × 10-4

   Extracellular matrix organisation and biosynthesis

4

 

1.11 × 10-3

   Microtubule based process

 

10

7.35 × 10-3

   Regulation of phosphorylation

3

 

5.30 × 10-3

Morphogenesis

18

 

5.34 × 10-4

   Cellular morphogenesis

9

 

5.60 × 10-3

   Mesoderm formation

2

 

4.46 × 10-3

   Organ morphogenesis

8

 

7.46 × 10-3

Organ development

23

 

3.45 × 10-7

   Cartilage condensation

2

 

5.89 × 10-3

   Eye development

3

 

4.98 × 10-4

   Muscle development

6

 

2.52 × 10-3

   Skeletal development

11

 

1.18 × 10-6

Regulation of development

   

   Negative regulation of development

3

 

2.28 × 10-3

Response to abiotic stimulus

   

   Response to chemical stimulus

 

20

7.31 × 10-3

   Response to reactive oxygen species

 

3

5.21 × 10-3

Response to biotic stimulus

 

116

5.73 × 10-41

   Defence response to bacteria

 

11

5.2 x10-9

   Defence response to fungi

 

3

1.65 × 10-3

   Response to virus

 

7

9.11 × 10-3

   Immune response

 

100

1.61 × 10-34

   Humoral immune response

 

22

1.57 × 10-8

   Inflammatory response

 

23

3.08 × 10-7

  1. Classification of gene ontologies (GO) significantly over-represented (P < 0.01) for genes at least 2 fold differentially expressed between unfused and fused sutures, listed under level 3 GO category headings. Not all level three GO categories listed were significantly over-represented and thus do not have a P-value