From: Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis
Biological process increased in sutures: | Unfused | Fused | P-value |
---|---|---|---|
Cell adhesion | 32 |  | 1.95 × 10-12 |
   Cell matrix adhesion | 4 |  | 6.53 × 10-3 |
Cell communication | Â | Â | Â |
   Cell surface receptor linked signal transduction | 25 |  | 4.45 × 10-3 |
   Dopamine metabolism | 2 |  | 6.63 × 10-4 |
   Phosphoinsitide-mediated signalling |  | 8 | 4.58 × 10-3 |
Cell differentiation | Â | Â | Â |
   Heme biosynthesis |  | 3 | 6.96 × 10-3 |
   Lymphocyte differentiation |  | 6 | 1.27 × 10-3 |
Cellular physiological process | Â | Â | Â |
   Anion transport | 11 |  | 4.92 × 10-6 |
   Cell cycle |  | 42 | 4.72 × 10-5 |
   Cell motility | 11 |  | 2.70 × 10-4 |
   Extracellular matrix organisation and biosynthesis | 4 |  | 1.11 × 10-3 |
   Microtubule based process |  | 10 | 7.35 × 10-3 |
   Regulation of phosphorylation | 3 |  | 5.30 × 10-3 |
Morphogenesis | 18 |  | 5.34 × 10-4 |
   Cellular morphogenesis | 9 |  | 5.60 × 10-3 |
   Mesoderm formation | 2 |  | 4.46 × 10-3 |
   Organ morphogenesis | 8 |  | 7.46 × 10-3 |
Organ development | 23 |  | 3.45 × 10-7 |
   Cartilage condensation | 2 |  | 5.89 × 10-3 |
   Eye development | 3 |  | 4.98 × 10-4 |
   Muscle development | 6 |  | 2.52 × 10-3 |
   Skeletal development | 11 |  | 1.18 × 10-6 |
Regulation of development | Â | Â | Â |
   Negative regulation of development | 3 |  | 2.28 × 10-3 |
Response to abiotic stimulus | Â | Â | Â |
   Response to chemical stimulus |  | 20 | 7.31 × 10-3 |
   Response to reactive oxygen species |  | 3 | 5.21 × 10-3 |
Response to biotic stimulus |  | 116 | 5.73 × 10-41 |
   Defence response to bacteria |  | 11 | 5.2 x10-9 |
   Defence response to fungi |  | 3 | 1.65 × 10-3 |
   Response to virus |  | 7 | 9.11 × 10-3 |
   Immune response |  | 100 | 1.61 × 10-34 |
   Humoral immune response |  | 22 | 1.57 × 10-8 |
   Inflammatory response |  | 23 | 3.08 × 10-7 |