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Table 4 Top 25 genes up-regulated in hESC population, as compared to human universal reference RNA.

From: "NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells

N

Gene indexa

Gene name

Log2 Ratio

S.E.M (%)

Spot Error

1.

Hesx1

Homeo box expressed in ES cells 1

4.11

5.76

0.0575

2.

Grem1

Gremlin 1 homolog, cysteine knot superfamily

3.86

7.14

0.1012

3.

Cdh6

Cadherin 6 (K-cadherin)

3.49

3.88

0.0186

4.

Gja1

Gap junction protein, α1 (connexin 43)

3.49

7.10

0.0485

5.

Htr2b

5-hydroxytryptamine (serotonin) receptor 2B

3.45

8.91

0.0655

6.

Emx2

Empty spiracles homolog 2 (Drosophila)

3.24

6.10

0.1202

7.

Epo

Erythropoietin

3.22

9.67

0.0407

8.

Fzd7

Frizzled homolog 7 (Drosophila)

3.08

4.99

0.0317

9.

Kal1

Kallmann syndrome 1 sequence

3.05

3.10

0.0684

10.

Auts2

Autism susceptibility candidate 2

3.03

7.49

0.0088

11.

Zic3

Zic family member 3 heterotaxy 1

2.98

5.59

0.0709

12.

Rds

Retinal degeneration, slow

2.95

10.00

0.0756

13.

Ddit4l

DNA-damage-inducible transcript 4-like

2.90

4.90

0.0357

14.

Crispld1

Cysteine-rich secretory protein LCCL domain containing 1 (LOC83690)

2.87

5.04

0.0990

15.

Lrrn1

Leucine rich repeat neuronal 1

2.74

3.94

0.1002

16.

Gpr23

G protein-coupled receptor 23

2.74

6.02

0.0702

17.

Mgc16186

Hypothetical protein MGC16186

2.70

3.50

0.1592

18.

Par1

Prader-Willi/Angelman region-1

2.69

18.44

0.0953

19.

Nap1l3

Nucleosome assembly protein 1-like 3

2.69

4.00

0.0398

20.

Cecr2

Cat eye syndrome critical region protein 2

2.65

6.40

0.0082

21.

Fgfr2

Fibroblast growth factor receptor 2

2.64

5.11

0.0545

22.

Klkb1

Kallikrein B, plasma (Fletcher factor) 1

2.63

9.96

0.0255

23.

Calb1

Calbindin 1, 28kDa

2.61

1.45

0.0719

24.

Fbn3

Fibrillin 3

2.60

12.68

0.0462

25.

Id4

Inhibitor of DNA binding 4

2.50

6.44

0.0467

  1. Only entries with spot intensity in hESC sample >100 are shown. Entries are sorted based on average Log2 ratio (after filtering for expression in all 4 technical replicates). S.E.M., standard error of the mean expressed as percentage of the mean; Spot Error, estimate of the average measurement error for all spots for the given reporter across the 4 technical replicates.
  2. a Italics indicates genes down-regulated (Log2 ratio < -1.0) in dopaminergic differentiation experiment.