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An in-depth analysis of the genomes of the Q fever-causing bacterium Coxiella burnetii shows an evolutionary pattern based on the modification of existing genes, supporting a model of clonal expansion of established genotypes, with significant variation at protein level.
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Methylation levels of N6-adenine (6mA) and N4-cytosine (4mC) observed in metazoan samples may be due to bacterial contamination or incorporation of methylated nucleosides from exogenous DNA.
Dr. Jacqueline Smith is a Career Track Fellow at The Roslin Institute in Edinburgh. She joined the Editorial Board of BMC Genomics in 2015.
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