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  1. Coilia nasus is an important anadromous fish, widely distributed in China, Japan, and Korea. Based on morphological and ecological researches of C. nasus, two ecotypes were identified. One is the anadromous popul...

    Authors: Jun Gao, Gangchun Xu and Pao Xu

    Citation: BMC Genomics 2021 22:878

    Content type: Research

    Published on:

  2. With the emphasis on analysing genotype-by-environment interactions within the framework of genomic selection and genome-wide association analysis, there is an increasing demand for reliable tools that can be ...

    Authors: Xiujin Li, Hailiang Song, Zhe Zhang, Yunmao Huang, Qin Zhang and Xiangdong Ding

    Citation: BMC Genomics 2021 22:877

    Content type: Software

    Published on:

  3. The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic dri...

    Authors: Ayda Mirsalehi, Dragomira N. Markova, Mohammadmehdi Eslamieh and Esther Betrán

    Citation: BMC Genomics 2021 22:876

    Content type: Research

    Published on:

  4. Natural variation in protein expression is common in all organisms and contributes to phenotypic differences among individuals. While variation in gene expression at the transcript level has been extensively i...

    Authors: Alyssa Erickson, Suiping Zhou, Jie Luo, Ling Li, Xin Huang, Zachary Even, He Huang, Hai-Ming Xu, Junmin Peng, Lu Lu and Xusheng Wang

    Citation: BMC Genomics 2021 22:875

    Content type: Research article

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  5. The black rockfish (Sebastes schlegelii) has an ovoviviparous reproductive pattern and long-term sperm storage, resulting in asynchronous gonadal development between the sexes. However, the comprehensive understa...

    Authors: Jianshuang Li, Likang Lyu, Haishen Wen, Yun Li, Xiaojie Wang, Ying Zhang, Yijia Yao and Xin Qi

    Citation: BMC Genomics 2021 22:874

    Content type: Research article

    Published on:

  6. Pediatric cancers typically have a distinct genomic landscape when compared to adult cancers and frequently carry somatic gene fusion events that alter gene expression and drive tumorigenesis. Sensitive and sp...

    Authors: Stephanie LaHaye, James R. Fitch, Kyle J. Voytovich, Adam C. Herman, Benjamin J. Kelly, Grant E. Lammi, Jeremy A. Arbesfeld, Saranga Wijeratne, Samuel J. Franklin, Kathleen M. Schieffer, Natalie Bir, Sean D. McGrath, Anthony R. Miller, Amy Wetzel, Katherine E. Miller, Tracy A. Bedrosian…

    Citation: BMC Genomics 2021 22:872

    Content type: Methodology article

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  7. In insect societies, queens monopolize reproduction while workers perform tasks such as brood care or foraging. Queen loss leads to ovary development and lifespan extension in workers of many ant species. Howe...

    Authors: Marina Choppin, Barbara Feldmeyer and Susanne Foitzik

    Citation: BMC Genomics 2021 22:871

    Content type: Research

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  8. Dietary high fructose (HFr) is a known metabolic disruptor contributing to development of obesity and diabetes in Western societies. Initial molecular changes from exposure to HFr on liver metabolism may be es...

    Authors: Laura A. Cox, Jeannie Chan, Prahlad Rao, Zeeshan Hamid, Jeremy P. Glenn, Avinash Jadhav, Vivek Das, Genesio M. Karere, Ellen Quillen, Kylie Kavanagh and Michael Olivier

    Citation: BMC Genomics 2021 22:870

    Content type: Research

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  9. Endothelial cell senescence is the state of permanent cell cycle arrest and plays a critical role in the pathogenesis of age-related diseases. However, a comprehensive understanding of the gene regulatory netw...

    Authors: Momoko Ohori, Yusuke Nakayama, Mari Ogasawara-Shimizu, Hiroyoshi Toyoshiba, Atsushi Nakanishi, Samuel Aparicio and Shinsuke Araki

    Citation: BMC Genomics 2021 22:869

    Content type: Research

    Published on:

  10. As a popular and valuable technique, grafting is widely used to protect against soil-borne diseases and nematodes in vegetable production. Growing evidences have revealed that long intergenic ncRNAs (lincRNAs)...

    Authors: Junliang Yin, Jiahui Yan, Lu Hou, Liling Jiang, Wenrong Xian and Qingyun Guo

    Citation: BMC Genomics 2021 22:868

    Content type: Research

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  11. Xylan is one of the most abundant hemicelluloses and can crosslink cellulose and lignin to increase the stability of cell walls. A number of genes encoding glycosyltransferases play vital roles in xylan biosyn...

    Authors: Zhen Li, Xinyue Wang, Kebin Yang, Chenglei Zhu, Tingting Yuan, Jiongliang Wang, Ying Li and Zhimin Gao

    Citation: BMC Genomics 2021 22:867

    Content type: Research

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  12. In physoclist fishes filling of the swimbladder requires acid secretion of gas gland cells to switch on the Root effect and subsequent countercurrent concentration of the initial gas partial pressure increase ...

    Authors: Gabriel Schneebauer, Victoria Drechsel, Ron Dirks, Klaus Faserl, Bettina Sarg and Bernd Pelster

    Citation: BMC Genomics 2021 22:866

    Content type: Research

    Published on:

  13. Ramie is an important fiber-producing crop in China, and its fibers are widely used as textile materials. Fibers contain specialized secondary cellular walls that are mainly composed of cellulose, hemicellulos...

    Authors: Fu Li, Zheng Zeng, Renyan Huang, Yanzhou Wang and Touming Liu

    Citation: BMC Genomics 2021 22:865

    Content type: Research

    Published on:

  14. Prolamins, unique to Gramineae (grasses), play a key role in the human diet. Thinopyrum elongatum (syn. Agropyron elongatum or Lophopyrum elongatum), a grass of the Triticeae family with a diploid E genome (2n = ...

    Authors: Wenyang Ge, Yu Gao, Shoushen Xu, Xin Ma, Hongwei Wang, Lingrang Kong and Silong Sun

    Citation: BMC Genomics 2021 22:864

    Content type: Research

    Published on:

  15. Recently, erdafitinib (Balversa), the first targeted therapy drug for genetic alteration, was approved to metastatic urothelial carcinoma. Cancer genomics research has been greatly encouraged. Currently, a lar...

    Authors: Yongqing Zhang, Qingyuan Chen, Meiqin Gong, Yuanqi Zeng and Dongrui Gao

    Citation: BMC Genomics 2021 22(Suppl 1):863

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 22 Supplement 1

  16. To explore the long non-coding RNA (lncRNA) expression pattern of congenital lung malformations on a genome-wide scale and investigate their potential biological function in four subtypes of congenital lung ma...

    Authors: Weili Yang, Pu Zhao, Yun Liu, Ping Cao, Xiang Ji, Ya Gao, Peng Li and Jiwen Cheng

    Citation: BMC Genomics 2021 22:861

    Content type: Research

    Published on:

  17. As a powerful tool, RNA-Seq has been widely used in various studies. Usually, unmapped RNA-seq reads have been considered as useless and been trashed or ignored.

    Authors: Dongwei Li, Qitong Huang, Lei Huang, Jikai Wen, Jing Luo, Qing Li, Yanling Peng and Yubo Zhang

    Citation: BMC Genomics 2021 22:857

    Content type: Methodology article

    Published on:

  18. High-producing Holstein Friesian dairy cattle have a characteristic black and white coat, often with large proportions of black. Compared to a light coat color, black absorbs more solar radiation which is a co...

    Authors: G. Laible, S.-A. Cole, B. Brophy, J. Wei, S. Leath, S. Jivanji, M. D. Littlejohn and D. N. Wells

    Citation: BMC Genomics 2021 22:856

    Content type: Research

    Published on:

  19. Microexons are a particular kind of exon of less than 30 nucleotides in length. More than 60% of annotated human microexons were found to have high levels of sequence conservation, suggesting their potential f...

    Authors: Qi Cheng, Bo He, Chengkui Zhao, Hongyuan Bi, Duojiao Chen, Shuangze Han, Haikuan Gao and Weixing Feng

    Citation: BMC Genomics 2021 22:855

    Content type: Research

    Published on:

  20. Despite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood. The transcriptome effects of Traumeel (Tr14), a multicomponent natural...

    Authors: Georges St. Laurent III, Ian Toma, Bernd Seilheimer, Konstantin Cesnulevicius, Myron Schultz, Michael Tackett, Jianhua Zhou, Maxim Ri, Dmitry Shtokalo, Denis Antonets, Tisha Jepson and Timothy A. McCaffrey

    Citation: BMC Genomics 2021 22:854

    Content type: Research

    Published on:

  21. Idiopathic membranous nephropathy (IMN) is a cause of nephrotic syndrome that is increasing in incidence but has unclear pathogenesis. Urinary peptidomics is a promising technology for elucidating molecular me...

    Authors: Baoxu Lin, Jianhua Liu, Yue Zhang, Yabin Wu, Shixiao Chen, Yibo Bai, Qiuying Liu and Xiaosong Qin

    Citation: BMC Genomics 2021 22:852

    Content type: Research

    Published on:

  22. As the critical tissue of the central nervous system, the brain has been found to be involved in gonad development. Previous studies have suggested that gonadal fate may be affected by the brain. Identifying b...

    Authors: Xufang Shen, Hongwei Yan, Jieming Jiang, Weiyuan Li, Yuyu Xiong, Qi Liu and Ying Liu

    Citation: BMC Genomics 2021 22:851

    Content type: Research

    Published on:

  23. The detection and identification of single nucleotide polymorphism (SNP) is essential for determining patient disease susceptibility and the delivery of medicines targeted to the individual. At present, SNP ge...

    Authors: Baowei Li, Yanran Liu, Xiaodan Hao, Jinhua Dong, Limei Chen, Haimei Li, Wei Wu, Ying Liu, Jianxun Wang, Yin Wang and Peifeng Li

    Citation: BMC Genomics 2021 22:850

    Content type: Methodology article

    Published on:

  24. Genome assembly of viruses with high mutation rates, such as Norovirus and other RNA viruses, or from metagenome samples, poses a challenge for the scientific community due to the coexistence of several viral ...

    Authors: Azahara Fuentes-Trillo, Carolina Monzó, Iris Manzano, Cristina Santiso-Bellón, Juliana da Silva Ribeiro de Andrade, Roberto Gozalbo-Rovira, Ana-Bárbara García-García, Jesús Rodríguez-Díaz and Felipe Javier Chaves

    Citation: BMC Genomics 2021 22:849

    Content type: Methodology article

    Published on:

  25. The genus Xanthomonas has long been considered to consist predominantly of plant pathogens, but over the last decade there has been an increasing number of reports on non-pathogenic and endophytic members. As Xan...

    Authors: Dennie te Molder, Wasin Poncheewin, Peter J. Schaap and Jasper J. Koehorst

    Citation: BMC Genomics 2021 22:848

    Content type: Research

    Published on:

  26. Fundamental knowledge of cellular and molecular mechanisms in developing testicular tissues is critical to better understand gonadal biology and responses to non-physiological conditions. The objective of our ...

    Authors: Olga Amelkina, Andreia M. da Silva, Alexandre R. Silva and Pierre Comizzoli

    Citation: BMC Genomics 2021 22:847

    Content type: Research

    Published on:

  27. Covalent modifications of core histones govern downstream DNA-templated processes such as transcription by altering chromatin structure and function. Previously, we reported that the plant homeodomain protein ...

    Authors: Isabel Cristina Vélez-Bermúdez and Wolfgang Schmidt

    Citation: BMC Genomics 2021 22:845

    Content type: Research

    Published on:

  28. Tuberculosis is one of the deadliest disease caused by Mycobacterium tuberculosis. Its treatment still becomes a burden for many countries including Indonesia. Drug resistance is one of the problems in TB treatme...

    Authors: Yustinus Maladan, Hana Krismawati, Tri Wahyuni, Ratna Tanjung, Kamla Awaludin, Kholis Abdurachim Audah and Arli Aditya Parikesit

    Citation: BMC Genomics 2021 22:844

    Content type: Research

    Published on:

  29. Scab is the most important fungal disease of apple and pear. Apple (Malus x domestica Borkh.) and European pear (Pyrus communis L.) are genetically related but they are hosts of two different fungal species: Vent...

    Authors: L. Perchepied, E. Chevreau, E. Ravon, S. Gaillard, S. Pelletier, M. Bahut, P. Berthelot, R. Cournol, H. J. Schouten and E. Vergne

    Citation: BMC Genomics 2021 22:843

    Content type: Research

    Published on:

  30. Transposable elements (TEs) are common features in eukaryotic genomes that are known to affect genome evolution critically and to play roles in gene regulation. Vertebrate genomes are dominated by TEs, which c...

    Authors: Mohanad A. Ibrahim, Badr M. Al-Shomrani, Mathew Simenc, Sultan N. Alharbi, Fahad H. Alqahtani, Mohamed B. Al-Fageeh and Manee M. Manee

    Citation: BMC Genomics 2021 22:842

    Content type: Research article

    Published on:

  31. Mycobacterium tuberculosis, the etiological agent of tuberculosis, has at least four ATP-Binding Cassette (ABC) transporters dedicated to carbohydrate uptake: LpqY/SugABC, UspABC, Rv2038c-41c, and UgpAEBC. LpqY/S...

    Authors: Lilia I. De la Torre, José G. Vergara Meza, Sindy Cabarca, André G. Costa-Martins and Andrea Balan

    Citation: BMC Genomics 2021 22:841

    Content type: Research article

    Published on:

  32. Sanghuangporus sanghuang is a well-known traditional medicinal mushroom associated with mulberry. Despite the properties of this mushroom being known for many years, the regulatory mechanisms of bioactive compoun...

    Authors: Tong Wang, Guangyuan Wang, Guoli Zhang, Ranran Hou, Liwei Zhou and Xuemei Tian

    Citation: BMC Genomics 2021 22:840

    Content type: Research

    Published on:

  33. Bupleurum chinense DC. is a widely used traditional Chinese medicinal plant. Saikosaponins are the major bioactive constituents of B. chinense, but relatively little is known about saikosaponin biosynthesis. In t...

    Authors: Yilian He, Hua Chen, Jun Zhao, Yuxia Yang, Bin Yang, Liang Feng, Yiguan Zhang, Ping Wei, Dabin Hou, Junning Zhao and Ma Yu

    Citation: BMC Genomics 2021 22:839

    Content type: Research

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  34. Black pepper (Piper nigrum L.), an important and long-cultivated spice crop, is native to South India and grown in the tropics. Piperine is the main pungent and bioactive alkaloid in the berries of black pepper, ...

    Authors: Yuanhao Ding, Yuyuan Mao, Yi Cen, Lisong Hu, Yuefeng Su, Xuemin Ma, Lu Long, Haiyan Hu, Chaoyun Hao and Jie Luo

    Citation: BMC Genomics 2021 22:838

    Content type: Research

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  35. Rapid anthropogenic climate change will require species to adapt to shifting environmental conditions, with successful adaptation dependent upon current patterns of genetic variation. While landscape genomic a...

    Authors: Nathan W. Byer, Emily D. Fountain, Brendan N. Reid, Kristen Miller, Paige J. Kulzer and M. Zachariah Peery

    Citation: BMC Genomics 2021 22:837

    Content type: Research

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  36. Bean pyralid is one of the major leaf-feeding insects that affect soybean crops. DNA methylation can control the networks of gene expressions, and it plays an important role in responses to biotic stress. Howe...

    Authors: Wei-Ying Zeng, Yu-Rong Tan, Sheng-Feng Long, Zu-Dong Sun, Zhen-Guang Lai, Shou-Zhen Yang, Huai-Zhu Chen and Xia-Yan Qing

    Citation: BMC Genomics 2021 22:836

    Content type: Research

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  37. A large number of variants have been employed in various medical applications, such as providing medication instructions, disease susceptibility testing, paternity testing, and tumour diagnosis. A high multipl...

    Authors: Jie Yuan, Ji Yi, Meixiao Zhan, Qingqing Xie, Ting Ting Zhen, Jian Zhou, Zeqing Li and Zhou Li

    Citation: BMC Genomics 2021 22:835

    Content type: Software

    Published on:

  38. Panax ginseng is a well-known medicinal plant worldwide. As an herbal medicine, ginseng is also known for its long lifecycle, which can reach several decades. WRKY proteins play regulatory roles in many aspects o...

    Authors: Peng Di, Ping Wang, Min Yan, Peng Han, Xinyi Huang, Le Yin, Yan Yan, Yonghua Xu and Yingping Wang

    Citation: BMC Genomics 2021 22:834

    Content type: Research article

    Published on:

  39. Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer. Approximately 80% of patients initially diagnosed with locally advanced or metastatic disease survive only 4–11 months after diagnosis. Tremendous ef...

    Authors: Hongjin Wu, Weiwei Tian, Xiang Tai, Xuanpeng Li, Ziwei Li, Jing Shui, Juehua Yu, Zhihua Wang and Xiaosong Zhu

    Citation: BMC Genomics 2021 22:833

    Content type: Research

    Published on:

  40. The salmon louse (Lepeophtheirus salmonis) is an obligate ectoparasitic copepod living on Atlantic salmon and other salmonids in the marine environment. Salmon lice cause a number of environmental problems and le...

    Authors: Zhaoran Zhou, Christiane Eichner, Frank Nilsen, Inge Jonassen and Michael Dondrup

    Citation: BMC Genomics 2021 22:832

    Content type: Research

    Published on:

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