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  1. Bi-specific T-cell engager (BiTE) antibody is a class of bispecific antibodies designed for cancer immunotherapy. Blinatumomab is the first approved BiTE to treat acute B cell lymphoblastic leukemia (B-ALL). I...

    Authors: Yi Huo, Zhen Sheng, Daniel R. Lu, Daniel C. Ellwanger, Chi-Ming Li, Oliver Homann, Songli Wang, Hong Yin and Ruibao Ren

    Citation: BMC Genomics 2021 22:145

    Content type: Research article

    Published on:

  2. Host immune function can contribute to numerous ecological/evolutionary processes. Ecoimmunological studies, however, typically use one/few phenotypic immune assays and thus do not consider the complexity of t...

    Authors: Otto Seppälä, Jean-Claude Walser, Teo Cereghetti, Katri Seppälä, Tiina Salo and Coen M. Adema

    Citation: BMC Genomics 2021 22:144

    Content type: Research article

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  3. The giant panda (Ailuropoda melanoleuca) is a threatened endemic Chinese species and a flagship species of national and global conservation concern. Life history theory proposes that reproduction and immunity can...

    Authors: Haibo Shen, Caiwu Li, Ming He, Yan Huang, Jing Wang, Minglei Wang, Bisong Yue and Xiuyue Zhang

    Citation: BMC Genomics 2021 22:143

    Content type: Research article

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  4. Tartary buckwheat (Fagopyrum tataricum), an important pseudocereal crop, has high economic value due to its nutritional and medicinal properties. However, dehulling of Tartary buckwheat is difficult owing to its ...

    Authors: Tao-Xiong Shi, Rui-Yuan Li, Ran Zheng, Qing-Fu Chen, Hong-You Li, Juan Huang, Li-Wei Zhu and Cheng-Gang Liang

    Citation: BMC Genomics 2021 22:142

    Content type: Research article

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  5. Sweetpotato (Ipomoea batatas (L.) Lam.) serves as an important food source for human beings. β-galactosidase (bgal) is a glycosyl hydrolase involved in cell wall modification, which plays essential roles in plant...

    Authors: Fuyun Hou, Taifeng Du, Zhen Qin, Tao Xu, Aixian Li, Shunxu Dong, Daifu Ma, Zongyun Li, Qingmei Wang and Liming Zhang

    Citation: BMC Genomics 2021 22:140

    Content type: Research article

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  6. The transcriptional changes around the time of embryonic genome activation in pre-implantation embryos indicate that this process is highly dynamic. In vitro produced porcine blastocysts are known to be less c...

    Authors: Vera A. van der Weijden, Meret Schmidhauser, Mayuko Kurome, Johannes Knubben, Veronika L. Flöter, Eckhard Wolf and Susanne E. Ulbrich

    Citation: BMC Genomics 2021 22:139

    Content type: Research article

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  7. Chloroplast genome resources can provide useful information for the evolution of plant species. Tea plant (Camellia sinensis) is among the most economically valuable member of Camellia. Here, we determined the ch...

    Authors: Li Li, Yunfei Hu, Min He, Bo Zhang, Wei Wu, Pumo Cai, Da Huo and Yongcong Hong

    Citation: BMC Genomics 2021 22:138

    Content type: Research article

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  8. Mitochondrial transcription termination factor (mTERF) is a large gene family which plays a significant role during plant growth under various environmental stresses. However, knowledge of mTERF genes in grape...

    Authors: Xiangjing Yin, Yu Gao, Shiren Song, Danial Hassani and Jiang Lu

    Citation: BMC Genomics 2021 22:136

    Content type: Research article

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  9. The ladybird beetle Cryptolaemus montrouzieri Mulsant, 1853 (Coleoptera, Coccinellidae) is used worldwide as a biological control agent. It is a predator of various mealybug pests, but it also feeds on alternativ...

    Authors: Hao-Sen Li, Yu-Hao Huang, Mei-Lan Chen, Zhan Ren, Bo-Yuan Qiu, Patrick De Clercq, Gerald Heckel and Hong Pang

    Citation: BMC Genomics 2021 22:135

    Content type: Research article

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  10. Bone marrow mesenchymal stem cells are a potential resource for the clinical therapy of certain diseases. Canine, as a companion animal, living in the same space with human, is an ideal new model for human dis...

    Authors: Jinglu Wang, Pengxiu Dai, Tong Zou, Yangou Lv, Wen Zhao, Xinke Zhang and Yihua Zhang

    Citation: BMC Genomics 2021 22:134

    Content type: Research article

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  11. Not all cells in a given individual are identical in their genomic makeup. Mosaicism describes such a phenomenon where a mixture of genotypic states in certain genomic segments exists within the same individua...

    Authors: Joseph T. Glessner, Xiao Chang, Yichuan Liu, Jin Li, Munir Khan, Zhi Wei, Patrick M. A. Sleiman and Hakon Hakonarson

    Citation: BMC Genomics 2021 22:133

    Content type: Software

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  12. The root system provides nutrient absorption and is closely related to abiotic stress tolerance, but it is difficult to study the roots under field conditions. This study was conducted to identify quantitative...

    Authors: Huatao Chen, Giriraj Kumawat, Yongliang Yan, Baojie Fan and Donghe Xu

    Citation: BMC Genomics 2021 22:132

    Content type: Research article

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  13. Saccharomycodes ludwigii belongs to the poorly characterized Saccharomycodeacea family and is known by its ability to spoil wines, a trait mostly attributable to its high tolerance to sulfur dioxide (SO2). To imp...

    Authors: Maria J. Tavares, Ulrich Güldener, Ana Mendes-Ferreira and Nuno P. Mira

    Citation: BMC Genomics 2021 22:131

    Content type: Research article

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  14. Toxoplasma gondii is a globally distributed protozoan parasite that establishes life-long asymptomatic infection in humans, often emerging as a life-threatening opportunistic pathogen during immunodeficiency. As ...

    Authors: Kayla L. Menard, Lijing Bu and Eric Y. Denkers

    Citation: BMC Genomics 2021 22:130

    Content type: Research article

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  15. As economical traits, food habits domestication can reduce production cost in aquaculture. However, the molecular mechanism underlying food habits domestication has remained elusive. Mandarin fish (Siniperca chua...

    Authors: Shan He, Jun-Jie You, Xu-Fang Liang, Zhi-Lu Zhang and Yan-Peng Zhang

    Citation: BMC Genomics 2021 22:129

    Content type: Research article

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  16. Pregnancy-specific glycoprotein (PSG) genes belong to the carcinoembryonic antigen (CEA) gene family, within the immunoglobulin gene superfamily. In humans, 10 PSG genes encode closely related secreted glycoprote...

    Authors: Wolfgang Zimmermann and Robert Kammerer

    Citation: BMC Genomics 2021 22:128

    Content type: Research article

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  17. The quality and yield of wool determine the economic value of the fine-wool sheep. Therefore, discovering markers or genes relevant to wool traits is the cornerstone for the breeding of fine-wool sheep. In thi...

    Authors: Hongchang Zhao, Tingting Guo, Zengkui Lu, Jianbin Liu, Shaohua Zhu, Guoyan Qiao, Mei Han, Chao Yuan, Tianxiang Wang, Fanwen Li, Yajun Zhang, Fujun Hou, Yaojing Yue and Bohui Yang

    Citation: BMC Genomics 2021 22:127

    Content type: Research article

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  18. 2-Oxoglutarate and Fe(II)-dependent dioxygenases (2ODDs) belong to the 2-oxoglutarate-dependent dioxygenase (2OGD) superfamily and are involved in various vital metabolic pathways of plants at different develo...

    Authors: Shuo Wei, Wen Zhang, Rao Fu and Yang Zhang

    Citation: BMC Genomics 2021 22:126

    Content type: Research article

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  19. The ongoing COVID-19 outbreak has caused devastating mortality and posed a significant threat to public health worldwide. Despite the severity of this illness and 2.3 million worldwide deaths, the disease mech...

    Authors: Yue Li, Ashley Duche, Michael R. Sayer, Don Roosan, Farid G. Khalafalla, Rennolds S. Ostrom, Jennifer Totonchy and Moom R. Roosan

    Citation: BMC Genomics 2021 22:125

    Content type: Research article

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  20. Micrococcus luteus is a group of actinobacteria that is widely used in biotechnology and is being thought as an emerging nosocomial pathogen. With one of the smallest genomes of free-living actinobacteria, it is ...

    Authors: Yisong Li, Zhong-Zhi Sun, Jin-Cheng Rong and Bin-Bin Xie

    Citation: BMC Genomics 2021 22:124

    Content type: Research article

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  21. Heterosis has been extensively utilized in different crops and made a significant contribution to global food security. Genetic distance (GD) is one of the valuable criteria for selecting parents in hybrid bre...

    Authors: Xiaoli Geng, Yujie Qu, Yinhua Jia, Shoupu He, Zhaoe Pan, Liru Wang and Xiongming Du

    Citation: BMC Genomics 2021 22:123

    Content type: Research article

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  22. Heat stress (HS) is a major stress event in the life of an animal, with detrimental upshots in production and health. Long-non-coding RNAs (lncRNAs) play an important role in many biological processes by trans...

    Authors: Jinhuan Dou, Flavio Schenkel, Lirong Hu, Adnan Khan, Muhammad Zahoor Khan, Ying Yu, Yajing Wang and Yachun Wang

    Citation: BMC Genomics 2021 22:122

    Content type: Research article

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  23. Autophagy, meaning ‘self-eating’, is required for the degradation and recycling of cytoplasmic constituents under stressful and non-stressful conditions, which helps to maintain cellular homeostasis and delay ...

    Authors: Huan Wang, Zhaotang Ding, Mengjie Gou, Jianhui Hu, Yu Wang, Lu Wang, Yuchun Wang, Taimei Di, Xinfu Zhang, Xinyuan Hao, Xinchao Wang, Yajun Yang and Wenjun Qian

    Citation: BMC Genomics 2021 22:121

    Content type: Research article

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  24. Insect body coloration often functions as camouflage to survive from predators or mate selection. Transportation of pigment precursors or related metabolites from cytoplasm to subcellular pigment granules is o...

    Authors: Guichun Liu, Wei Liu, Ruoping Zhao, Jinwu He, Zhiwei Dong, Lei Chen, Wenting Wan, Zhou Chang, Wen Wang and Xueyan Li

    Citation: BMC Genomics 2021 22:120

    Content type: Research article

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  25. The homologous recombination (HR) pathway is largely inactive in early embryos prior to the first cell division, making it difficult to achieve targeted gene knock-ins. The homology-mediated end joining (HMEJ)...

    Authors: Joseph R. Owen, Sadie L. Hennig, Bret R. McNabb, Tamer A. Mansour, Justin M. Smith, Jason C. Lin, Amy E. Young, Josephine F. Trott, James D. Murray, Mary E. Delany, Pablo J. Ross and Alison L. Van Eenennaam

    Citation: BMC Genomics 2021 22:118

    Content type: Research article

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  26. High-pressure processing (HPP) is a commonly used technique in the food industry to inactivate pathogens, including L. monocytogenes. It has been shown that L. monocytogenes is able to recover from HPP injuries a...

    Authors: Ilhan Cem Duru, Florentina Ionela Bucur, Margarita Andreevskaya, Bahareh Nikparvar, Anne Ylinen, Leontina Grigore-Gurgu, Tone Mari Rode, Peter Crauwels, Pia Laine, Lars Paulin, Trond Løvdal, Christian U. Riedel, Nadav Bar, Daniela Borda, Anca Ioana Nicolau and Petri Auvinen

    Citation: BMC Genomics 2021 22:117

    Content type: Research article

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  27. Processing and analyzing whole genome sequencing (WGS) is computationally intense: a single Illumina MiSeq WGS run produces ~ 1 million 250-base-pair reads for each of 24 samples. This poses significant obstac...

    Authors: Jayanthi Gangiredla, Hugh Rand, Daniel Benisatto, Justin Payne, Charles Strittmatter, Jimmy Sanders, William J. Wolfgang, Kevin Libuit, James B. Herrick, Melanie Prarat, Magaly Toro, Thomas Farrell and Errol Strain

    Citation: BMC Genomics 2021 22:114

    Content type: Software

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  28. Legume species are an important plant model because of their protein-rich physiology. The adaptability and productivity of legumes are limited by major biotic and abiotic stresses. Responses to these stresses ...

    Authors: Daniel Restrepo-Montoya, Phillip E. McClean and Juan M. Osorno

    Citation: BMC Genomics 2021 22:113

    Content type: Research article

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  29. In fish, minimally invasive blood sampling is widely used to monitor physiological stress with blood plasma biomarkers. As fish blood cells are nucleated, they might be a source a potential new markers derived...

    Authors: Madoka Vera Krick, Erick Desmarais, Athanasios Samaras, Elise Guéret, Arkadios Dimitroglou, Michalis Pavlidis, Costas Tsigenopoulos and Bruno Guinand

    Citation: BMC Genomics 2021 22:111

    Content type: Research article

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  30. The accumulation of intracellular fat depots is a polygenic trait. Therefore, the extent of lipid storage in the individuals of a species covers a broad range and is determined by many genetic factors. Quantit...

    Authors: Klavdija Pačnik, Mojca Ogrizović, Matthias Diepold, Tobias Eisenberg, Mia Žganjar, Gašper Žun, Beti Kužnik, Cene Gostinčar, Tomaž Curk, Uroš Petrovič and Klaus Natter

    Citation: BMC Genomics 2021 22:110

    Content type: Research article

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  31. Oil flax (linseed, Linum usitatissimum L.) is one of the most important oil crops., However, the increases in drought resulting from climate change have dramatically reduces linseed yield and quality, but very li...

    Authors: Wei Wang, Lei Wang, Ling Wang, Meilian Tan, Collins O. Ogutu, Ziyan Yin, Jian Zhou, Jiaomei Wang, Lijun Wang and Xingchu Yan

    Citation: BMC Genomics 2021 22:109

    Content type: Research article

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  32. In evolutionary theory, divergence and speciation can arise from long periods of reproductive isolation, genetic mutation, selection and environmental adaptation. After divergence, alleles can either persist i...

    Authors: Maulana M. Naji, Yuri T. Utsunomiya, Johann Sölkner, Benjamin D. Rosen and Gábor Mészáros

    Citation: BMC Genomics 2021 22:108

    Content type: Research article

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  33. Calf mortality generally occurs in calves prior to weaning, which is a serious problem in cattle breeding. Several causative variants of monogenic Mendelian disorders in calf mortality have been identified, wh...

    Authors: Shinji Sasaki, Youko Miki, Takayuki Ibi, Hiroyuki Wakaguri, Yuichi Yoshida, Yoshikazu Sugimoto and Yutaka Suzuki

    Citation: BMC Genomics 2021 22:107

    Content type: Research article

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  34. The polynucleotide phosphorylase (PNPase) is conserved among both Gram-positive and Gram-negative bacteria. As a core part of the Escherichia coli degradosome, PNPase is involved in maintaining proper RNA levels ...

    Authors: Daniel-Timon Spanka, Carina Maria Reuscher and Gabriele Klug

    Citation: BMC Genomics 2021 22:106

    Content type: Research article

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  35. Dissolved oxygen (DO) in the water is a vital abiotic factor in aquatic animal farming. A hypoxic environment affects the growth, metabolism, and immune system of fish. Glycolipid metabolism is a vital energy ...

    Authors: Jun-Lei Ma, Jun Qiang, Yi-Fan Tao, Jing-Wen Bao, Hao-Jun Zhu, Lian-Ge Li and Pao Xu

    Citation: BMC Genomics 2021 22:105

    Content type: Research article

    Published on:

  36. Atractylodes DC is the basic original plant of the widely used herbal medicines “Baizhu” and “Cangzhu” and an endemic genus in East Asia. Species within the genus have minor morphological differences, and the uni...

    Authors: Yiheng Wang, Sheng Wang, Yanlei Liu, Qingjun Yuan, Jiahui Sun and Lanping Guo

    Citation: BMC Genomics 2021 22:103

    Content type: Research article

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  37. Staphylococcus and Streptococcus species can cause many different diseases, ranging from mild skin infections to life-threatening necrotizing fasciitis. Both genera consist of commensal species that colonize the ...

    Authors: Niels A. Zondervan, Vitor A. P. Martins dos Santos, Maria Suarez-Diez and Edoardo Saccenti

    Citation: BMC Genomics 2021 22:102

    Content type: Research article

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  38. With numerous endemic subspecies representing four of its five evolutionary lineages, Europe holds a large fraction of Apis mellifera genetic diversity. This diversity and the natural distribution range have been...

    Authors: Jamal Momeni, Melanie Parejo, Rasmus O. Nielsen, Jorge Langa, Iratxe Montes, Laetitia Papoutsis, Leila Farajzadeh, Christian Bendixen, Eliza Căuia, Jean-Daniel Charrière, Mary F. Coffey, Cecilia Costa, Raffaele Dall’Olio, Pilar De la Rúa, M. Maja Drazic, Janja Filipi…

    Citation: BMC Genomics 2021 22:101

    Content type: Methodology article

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  39. Cataracts are defects of the lens that cause progressive visual impairment and ultimately blindness in many vertebrate species. Most cataracts are age-related, but up to one third have an underlying genetic ca...

    Authors: Chao Bai, Yuyan You, Xuefeng Liu, Maohua Xia, Wei Wang, Ting Jia, Tianchun Pu, Yan Lu, Chenglin Zhang, Xiaoguang Li, Yanqiang Yin, Liqin Wang, Jun Zhou and Lili Niu

    Citation: BMC Genomics 2021 22:100

    Content type: Research article

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  40. Availability of plant genome sequences has led to significant advances. However, with few exceptions, the great majority of existing genome assemblies are derived from short read sequencing technologies with h...

    Authors: Peipei Wang, Fanrui Meng, Bethany M. Moore and Shin-Han Shiu

    Citation: BMC Genomics 2021 22:99

    Content type: Research article

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  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Gurusamy Raman, Kyu Tae Park, Joo-Hwan Kim and SeonJoo Park

    Citation: BMC Genomics 2021 22:97

    Content type: Correction

    Published on:

    The original article was published in BMC Genomics 2020 21:855

  42. Despite the increasing use of RNAseq for transcriptome analysis, microarrays remain a widely-used methodology for genomic studies. The latest generation of Affymetrix/Thermo-Fisher microarrays, the ClariomD/XT...

    Authors: Guy M. Harris, Shahroze Abbas and Michael F. Miles

    Citation: BMC Genomics 2021 22:96

    Content type: Software

    Published on:

  43. Intramuscular fat (IMF) is associated with meat quality and insulin resistance in animals. Research on genetic mechanism of IMF decomposition has positive meaning to pork quality and diseases such as obesity a...

    Authors: Ligang Wang, Zhong-Yin Zhou, Tian Zhang, Longchao Zhang, Xinhua Hou, Hua Yan and Lixian Wang

    Citation: BMC Genomics 2021 22:95

    Content type: Research article

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  44. Paeonia lactiflora ‘Hangshao’ is widely cultivated in China as a traditional Chinese medicine ‘Radix Paeoniae Alba’. Due to the abundant unsaturated fatty acids in its seed, it can also be regarded as a new oilse...

    Authors: Jia-Song Meng, Yu-Han Tang, Jing Sun, Da-Qiu Zhao, Ke-Liang Zhang and Jun Tao

    Citation: BMC Genomics 2021 22:94

    Content type: Research article

    Published on:

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