Figure 4

Comparative analysis of arsenite sensitivity data. (A) Comparison and visualization of arsenite sensitivity data from this work and other studies [31, 33]. Hierarchical cluster analysis of mutants that were scored as As sensitive and of the functional categories (according to FunCats (MIPS)) in the corresponding data sets that were significantly (p-value < 0.005) enriched for As sensitive mutants in at least one of the studies. Parent terms are in capitals, child terms in lower case letters. The colour indicates the fold enrichment of genes within individual categories. (B) Arsenite sensitive mutants in the sulphur assimilation and glutathione biosynthesis pathways identified by individual screens (this work and [31, 33]). Red circles: identified by one screen only; green circles: identified by at least two studies.