Missing call bias in high-throughput genotyping

BMC Genomics

Table 2 The power under different modes of inheritance relationship in the significant of 0.05.

Disease Models	Penetrances (h_AA, h_Aa, h_aa)	Scenarios	Power in Allelic χ²test			Power in Genotypic χ²test
			Null	MCB	UBM	Null	MCB	UBM
		I	0.805	0.790	0.800	0.806	0.800	0.800
Dominant	(0.0148, 0.0148, 0.01)	II & III	0.805	0.799	0.770	0.806	0.762	0.769
		IV	0.805	0.730	0.762	0.806	0.756	0.759
		I	0.619	0.472	0.611	0.801	0.710	0.794
Recessive	(0.0201, 0.01, 0.01)	II & III	0.619	0.691	0.586	0.801	0.798	0.769
		IV	0.619	0.599	0.569	0.801	0.796	0.751
		I	0.495	0.536	0.490	0.796	0.792	0.791
Overdominant	(0.01, 0.0148, 0.01)	II & III	0.495	0.447	0.461	0.796	0.736	0.758
		IV	0.495	0.406	0.453	0.796	0.757	0.748
		I	0.869	0.831	0.864	0.800	0.770	0.793
Additive	(0.0178, 0.0139, 0.01)	II & III	0.869	0.880	0.840	0.800	0.776	0.763
		IV	0.869	0.816	0.831	0.800	0.756	0.752
		I	0.875	0.831	0.870	0.800	0.763	0.793
Multiplicative	(0.01847, 0.01359, 0.01)	II & III	0.875	0.889	0.847	0.800	0.782	0.763
		IV	0.875	0.826	0.838	0.800	0.759	0.752

MAF is 0.25 and the sample size in case and control is 500 respectively. Null, the power in absence of missing; MCB, the power affected by missing call bias; UBM, the power when missing equivalently but unbiasedly across different genotypes.

ISSN: 1471-2164