Skip to main content

Table 2 The power under different modes of inheritance relationship in the significant of 0.05.

From: Missing call bias in high-throughput genotyping

Disease Models Penetrances (h AA , h Aa , h aa ) Scenarios Power in Allelic χ2test Power in Genotypic χ2test
    Null MCB UBM Null MCB UBM
   I 0.805 0.790 0.800 0.806 0.800 0.800
Dominant (0.0148, 0.0148, 0.01) II & III 0.805 0.799 0.770 0.806 0.762 0.769
   IV 0.805 0.730 0.762 0.806 0.756 0.759
   I 0.619 0.472 0.611 0.801 0.710 0.794
Recessive (0.0201, 0.01, 0.01) II & III 0.619 0.691 0.586 0.801 0.798 0.769
   IV 0.619 0.599 0.569 0.801 0.796 0.751
   I 0.495 0.536 0.490 0.796 0.792 0.791
Overdominant (0.01, 0.0148, 0.01) II & III 0.495 0.447 0.461 0.796 0.736 0.758
   IV 0.495 0.406 0.453 0.796 0.757 0.748
   I 0.869 0.831 0.864 0.800 0.770 0.793
Additive (0.0178, 0.0139, 0.01) II & III 0.869 0.880 0.840 0.800 0.776 0.763
   IV 0.869 0.816 0.831 0.800 0.756 0.752
   I 0.875 0.831 0.870 0.800 0.763 0.793
Multiplicative (0.01847, 0.01359, 0.01) II & III 0.875 0.889 0.847 0.800 0.782 0.763
   IV 0.875 0.826 0.838 0.800 0.759 0.752
  1. MAF is 0.25 and the sample size in case and control is 500 respectively. Null, the power in absence of missing; MCB, the power affected by missing call bias; UBM, the power when missing equivalently but unbiasedly across different genotypes.