Prediction of disease-related mutations affecting protein localization

BMC Genomics

Table 1 Prediction results for the localization of wild type proteins with the individual predictors^a

Compartment	tp	rp	tn	fn	Accuracy	Precision	Recall	MCC	Proteins located
TargetP (mitochodrial)	101	109	1254	52	0.894	0.481	0.660	0.506	210
TMHMM	377	144	853	142	0.811	0.724	0.726	0.581	521
Golgipredictor	23	178	227	20	0.558	0.114	0.535	0.056	201
PeroxiP	6	24	423	12	0.923	0.200	0.333	0.220	30
PTS1	3	1	446	15	0.966	0.750	0.167	0.343	4
PredictNLS	98	23	248	217	0.590	0.810	0.311	0.279	121
Summary					0.790^b	0.513^b	0.455^b	0.331^b	1087

^atp, the number of positive cases that were correctly predicted; tn, the number of negative cases correctly predicted; fp, the number of positive cases incorrectly predicted; fn, the number of negative cases incorrectly predicted.
^baverage value.

ISSN: 1471-2164