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Table 4 Overlapping genes identified by expression and fitness profiling approaches under iron-limited conditions

From: Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae

Gene ID Gene Name Log2 expression Log2 fitness Protein function Cellular localization
YCR007C 1   0.47 -0.98 Unknown Plasma membrane
YMR058W 1 FET3 0.76 -3.85 Multicopper oxidase Plasma membrane
YLR214W 1 FRE1 0.93 -2.21 Ferric (and cupric) reductase Plasma membrane
YKR052C 1 MRS4 0.50 -3.55 Mitochondrial carrier protein Mitochondria
YJL094C 1 KHA1 0.40 -2.51 Putative H+/K+ antiporter Membrane
YHL027W 1 RIM101 0.76 -2.64 Transcriptional activator required for meiosis Nucleus
YDR271C 1   0.82 -2.56 Unknown, overlaps CCC2 Unknown
YDR270W 1 CCC2 0.63 -1.65 P-type ATPase Golgi apparatus
YPL182C 2   -0.29 -3.65 Cyc8-Tup1 interacting protein Nucleus
YPL170W 2 DAP1 -0.32 -4.33 Regulator of Erg11 Membrane
YGR270W 2 YTA7 -1.54 -1.52 ATPase activity Unknown
YLR304C 3 ACO1 -0.82 1.03 Aconitase (TCA cycle) Mitochondria
  1. 1Up-regulated and essential for optimal growth in iron deficiency
  2. 2Down-regulated and essential for optimal growth in iron deficiency
  3. 3Down-regulated and detrimental for optimal growth in iron deficiency