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Table 1 Oncogenic and prognostic gene signatures

From: Comparative expression pathway analysis of human and canine mammary tumors

Signature Type Model system
Akt Majumder 2004 Oncogenic Transgenic mouse prostate over-expressin human AKT1
Androgen Chen 2004 Oncogenic Treatment of LNCaP prostate cells with R1881
Androgen DePrimo 2002 Oncogenic Treatment of LNCaP prostate cells with R1881
β-catenin Bild 2006 Oncogenic Adenovirus infection of human primary mammary epithelial cells (HMECs)
Cell cycle Whitfield 2002 Oncogenic Synchronized HeLa cell cultures
CyclinD1 Lamb 2003 Oncogenic Adenovirus infection of MCF-7 breast cancer cells
E2F3 Bild 2006 Oncogenic Adenovirus infection of human primary mammary epithelial cells (HMECs)
EGFR Creighton 2006 Oncogenic Stable transfection of MCF-7 breast cancer cells
Hypoxia Chi 2006 Oncogenic Human cells from different tissues
MAPK Creighton 2006 Oncogenic Stable transfection of MCF-7 breast cancer cells
MEK Creighton 2006 Oncogenic Stable transfection of MCF-7 breast cancer cells
Myc Bild 2006 Oncogenic Adenovirus infection of human primary mammary epithelial cells (HMECs)
Myc Coller 2000 Oncogenic Conditional Myc-estrogen receptor fusion protein in human primary fibroblast cells
Raf1 Creighton 2006 Oncogenic Stable transfection of MCF-7 breast cancer cells
Ras Bild 2006 Oncogenic Adenovirus infection of human primary mammary epithelial cells (HMECs)
Src Bild 2006 Oncogenic Adenovirus infection of human primary mammary epithelial cells (HMECs)
Tamoxifen Chanrion 2008 Oncogenic Human primary breast tumors
PTEN Saal 2007 Oncogenic Human primary breast tumors
70 poor prognosis van't Veer 2002 Prognostic Human primary breast tumors
ERBB2 Creighton 2006 Prognostic Stable transfection of MCF-7 breast cancer cells
Grade 1–3 Ivshina 2006 Prognostic Human primary breast tumors
Proliferation signature Dai 2005 Prognostic Human primary breast tumors
Wound Chang 2004 Prognostic Response to serum exposure in fibroblasts from ten anatomic sites