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Table 1 A list of 20 most regulated annotated genes during vitellogenesis and after E2 treatment of males.

From: Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling

  Description Symbol GeneBank Vit4/NV Vit2/NV E/M Function according to http://www.ncbi.nlm.nih.gov/sites/entrez gene
1 Vitellogenin 3, phosvitinless vtg3 AF254638 103.3 94.5 125.7 Egg yolk precursor, phosvitinless.
2 Similar to reticulon 1 rtn1 BI983061 75.5 88.5 79.3 Associates with the endoplasmic reticulum.
3 Nothepsin, cathepsin e nots AJ278269 76.6 76.8 86.8 Eukaryotic aspartyl (acid) protease.
4 Similar to low density lipoprotein receptor ldlr BF717943 28.3 28.2 136.3 Plays a central role in cholesterol metabolism.
5 Moderately similar to spectrin repeat containing, nuclear envelope 1 syne1 AW019847 16.1 21.2 14.7 Involved in cytoskeletal structure.
6 Similar to ectonucleoside triphosphate diphosphohydrolase 4 entpd4 AW344063 97 70.2 25.5 Cleaving nucleotide tri- and diphosphates.
7 Similar to follistatin-like 1 fstl1 AI884233 NS NS 3.2 Play an important role in tissue specific regulation.
8 Similar to human Prefoldin subunit 6 pfdn6 BI891290 1.5 NS 3.7 Binds and stabilizes newly synthesized polypeptides.
9 Lag1 homolog, ceramide synthase 2 lass2 AW171063 1.8 NS 4.5 May play a role in the regulation of cell growth.
10 Ankyrin repeat domain 6 ank AF395113 12.3 10.3 4.3 Ankyrin repeats mediate protein-protein interactions.
11 Similar to nitric oxide synthase interacting protein nosip AI545274 8.1 7.4 11.6 Promotes translocation of eNOS from the plasma membrane to intracellular sites.
12 Similar to heterogeneous nuclear ribonucleoprotein h1 hnrnph1 AI497414 1.7 NS 2.8 RNA recognition/binding motif.
13 Similar to family with sequence similarity 46 c fam46c AI959558 4.5 4.7 14 The function of this gene is unknown.
14 Vitellogenin 1 vtg1 AF406784 7 6.3 28.6 Egg yolk precursor.
15 Similar to human guanylate binding protein1 gbp1 BM181499 8.5 8.2 2.7 Specifically bind guanine nucleotides (GMP, GDP, and GTP).
16 Similar to human protein fam20c precursor? fam20c BF717944 33.2 35.2 20.8 Has a crucial role in normal bone development.
17 Similar to glutamate receptor, ionotropic, kainate 1 grik1 BM071695 NS NS -16.4 Ligand-gated ion channel.
18 Similar to lectin, mannose-binding, 1 precursor lman1 AW175541 4.8 4 6.6 Mannose-specific lectin, a member of a Mannose-specific lectin, a member of a the secretory pathway of animal cells.
19 Similar to rna polymerase ii associated protein 1 rpap1 BM157210 NS NS 2.4 The function of this gene is unknown.
20 Estrogen receptor 1 esr1 AF349412 16 15.5 17 A ligand-activated transcription factor.
  1. Regulation during vitellogenesis is indicated as the ratio between Vit4/NV and Vit2/NV.
  2. Regulation by E2 is indicated by the ratio E/M. A weak similarity is indicated by a question mark (?). For the complete list of the regulated genes see Additional file 1.