Figure 11
Two distinct modes of nucleosome modulation for the two promoter classes. (A) Average values that quantify the levels of histone modification [33, 34] are shown for SDN-enriched promoters (green), SDN-less promoters (red). Values in each histone modification were normalized, such that their means are zero and standard deviations are one. Ac represents acetylation, while me indicates methylation (e.g. me2 indicates dimethylation). Error bars were calculated by bootstrapping. (B) A heatmap of ATP-dependent chromatin remodeling. Rows represent both promoter classes, and columns represent ATP-dependent chromatin remodelers (See additional file 1 for the corresponding list). Colors indicate K-S -log10P value, which provide a measure of the discrepancy in expression between SDN-enriched or SDN-less promoters and the rest of the promoters when ATP-dependent chromatin remodeler gene is mutated. Higher values indicate higher discrepancy.