Chromosome Y variants from different inbred mouse strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone

Table 3 Summary of results concerning circadian genes

		C57BL/6J		C57.YA		Interaction
Gene Symbol	Gene Name	FC	FDR	FC	FDR	FDR
Arntl	aryl hydrocarbon receptor nuclear translocator-like	-1.10	0.531	-5.30	0.000	0.006
Dbp	D site albumin promoter binding protein	-1.05	0.772	2.94	0.000	0.006
Tef	thyrotroph embryonic factor	1.02	0.851	2.16	0.001	0.008
Per2	period homolog 2 (Drosophila)	1.11	0.531	2.95	0.001	0.009
Cry2	cryptochrome 2 (photolyase-like)	-1.08	0.370	1.42	0.001	0.019
Clock	circadian locomoter output cycles kaput	-1.10	0.284	-1.62	0.001	0.024
Nr1d2	nuclear receptor subfamily 1, group D, member 2	1.08	0.561	1.84	0.001	0.033
Per3	period homolog 3 (Drosophila)	1.08	0.503	1.67	0.001	0.034
Rora	RAR-related orphan receptor alpha	1.02	0.845	1.46	0.002	0.081
Per1	period homolog 1 (Drosophila)	-1.01	0.923	1.92	0.004	0.087
Csnk1e	casein kinase 1, epsilon	1.02	0.826	1.23	0.016	0.230
Csnk1d	casein kinase 1, delta	1.04	0.789	1.23	0.061	0.437
Nr1d1	nuclear receptor subfamily 1, group D, member 1	-1.36	0.017	-1.39	0.006	0.920
Bhlhb2	basic helix-loop-helix domain containing, class B2	1.14	0.251	1.15	0.135	0.942

Genes were considered as "circadian" on the basis of information from both the KEGG pathway database and additional annotation from the literature. FC: fold change of CX over Sham operated animals; FDR: P-values for the interaction between strain and treatment effects after adjustment for multiple comparisons with an FDR transformation (see methods); FDR values < 0.1 are formatted in bold.

ISSN: 1471-2164