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Table 6 Substitution rates for alternative and constitutive regions of 5'UTR

From: Evolution of alternative and constitutive regions of mammalian 5'UTRs

Human-Macaque   Ka Ks K5(uORFs) K5(uORFs excluded)
ALT all 0.045 ± 0.001 0.052 ± 0.001 0.047 ± 0.001 0.054 ± 0.001
  ≥ 30 bp 0.046 ± 0.001 0.051 ± 0.002   
CONSTIT all 0.040 ± 0.001 0.046 ± 0.002 0.042 ± 0.001 0.051 ± 0.002
  ≥ 30 bp 0.041 ± 0.002 0.048 ± 0.003   
Mouse-Rat      
   Ka Ks K 5(uORFs) K 5(uORFs excluded)
ALT all 0.092 ± 0.002 0.111 ± 0.002 0.099 ± 0.002 0.098 ± 0.001
  ≥ 30 bp 0.094 ± 0.004 0.114 ± 0.005   
CONSTIT all 0.088 ± 0.003 0.103 ± 0.004 0.093 ± 0.002 0.100 ± 0.001
  ≥ 30 bp 0.091 ± 0.004 0.108 ± 0.007   
  1. Substitution rates for alternative and constitutive regions of 5'UTR were estimated for human-macaque (top tier) and mouse-rat (bottom tier). Evolutionary rates for non-synonymous (Ka) and synonymous (Ks) sites from uORFs within ALT and CONSTIT regions were estimated using the Pamilo-Bianchi-Li method. Rates were calculated for all uORFs (all) and for the subset of uORFs ≥ 30 nts in length (≥ 30 bp). Evolutionary rates were also calculated for regions of 5'UTR that contain uORFs (K5 uORFs) and for regions without (K5 uORFs excluded), using the Kimura-2-Parameter method.