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Table 5 Expression levels and interindividual differences of currently known macular disease genes with RPE expression[26].

From: Functional annotation of the human retinal pigment epithelium transcriptome

gene symbol Genbank accession mean intensity μint (perc) CV (perc)
high interindividual variation (CV > 10 th perc)
CFB NM_001710 10,382 (94) 215 (99)
C3 NM_000064 9,910 (94) 145 (98)
FBLN5 NM_006329 2,823 (76) 136 (98)
PRPH2 NM_000322 32,204 (98) 86 (93)
GUCA1B NM_002098 2,329 (72) 83 (93)
CST3 NM_000099 338 (26) 79 (92)
CFH NM_000186 8,508 (92) 77 (91)
TIMP3 NM_000362 7,209 (91) 73 (90)
intermediate interindividual variation (CV 10 th – 90 th perc)
C2 NM_000063 1,689 (65) 71 (90)
BEST1 NM_004183 132,611 (99) 58 (84)
HTRA1 NM_002775 45,420 (99) 47 (74)
EFEMP1 NM_004105 20,292 (97) 44 (70)
C1QTNF5 NM_015645 23,226 (98) 40 (64)
TLR4 NM_003266 225 (45) 38 (60)
low interindividual variation (CV < 90 th perc)
none - -   -  
  1. Data are grouped by coefficient of variation (CV) in descending order into three groups, high CV (> 90th percentile, CV > 72), intermediate (CV 10th – 90th percentile) and low CV (< 10th percentile, CV < 19). Perc: percentile.