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Table 4 Genes differentially affected by dichlorvos and fenamiphos exposure

From: Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans

ProbeSet WBIDa Geneb Description Biological Role Dicc Fend
191857_s_at WBGene00011462 scl-22 SCP-like extracellular protein   -1.2 -3.7
189735_at WBGene00002021 hsp-17 heat shock protein Stress 2.0 -1.0
190518_at WBGene00006629 tsp-3 tetraspanin   2.5 1.0
184400_at WBGene00017726 F22H10.2 unknown   3.2 1.7
192142_at WBGene00008084 C44C10.3 major facilitator superfamily transporter Detoxification 3.6 1.4
180425_s_at WBGene00017484 F15E6.3 RRM-type RNA binding protein miRNA regulation 4.0 1.9
180592_s_at WBGene00021224 clec-209 unknown function – contains c-type lectin domain   -2.1 2.0
178843_at WBGene00008584 F08G5.6 CUB domain containing protein   -2.3 4.9
193604_at WBGene00007455 ugt-22 UDP-glucoronosyl and UDP-glucosyl transferases Phase 2 enzyme -1.6 6.7
183703_s_at WBGene00012788 Y43D4A.2 UDP-glucoronosyl and UDP-glucosyl transferases Phase 2 enzyme -1.4 7.9
191418_at WBGene00013901 ugt-16 UDP-glucoronosyl and UDP-glucosyl transferases Phase 2 enzyme -1.8 7.7
189394_at WBGene00019473 cyp-35A5 cytochrome P450 Phase 1 enzyme -1.1 15.9
193924_at WBGene00003997 pgp-3 P-glycoprotein 3 Detoxification 1.0 3.1
190248_s_at WBGene00004008 pgp-14 P-glycoprotein 14 Detoxification -1.1 3.3
185525_at WBGene00015399 cyp-35A1 cytochrome P450 Phase 1 enzyme 1.1 4.3
188031_s_at WBGene00006890 vem-1 putative steroid membrane receptor – involved in axon guidance   1.6 5.7
191066_s_at WBGene00013906 ugt-5 UDP-glucoronosyl and UDP-glucosyl transferases Phase 2 enzyme 2.2 5.6
188962_at WBGene00019234 ugt-8 ugt family, 7TM chemoreceptor Phase 2 enzyme 1.2 10.4
178316_at WBGene00007811 C29F7.2 unknown   2.0 9.8
188217_at WBGene00004236 ptr-22 sterol sensing domain protein – patch related Sterol trafficking 2.4 14.7
189282_at WBGene00007362 cyp-35C1 cytochrome P450 Phase 1 enzyme 1.8 54.5
189283_s_at WBGene00007362 cyp-35C1 cytochrome P450 Phase 1 enzyme 2.3 54.7
189512_at WBGene00015400 cyp-35A2 cytochrome P450 Phase 1 enzyme 3.0 33.2
  1. a- WormBase gene identifier
  2. b- Gene names and descriptions were derived from WormBase, release WS189 [46].
  3. c- Gene expression fold change values for dichlorvos SVM predicted high concentration
  4. d- Gene expression fold change values for fenamiphos high concentration
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BMC Genomics

ISSN: 1471-2164

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