| Â | Pig | Sheep | Cattle | Mouse | Human |
|---|
Gene | Position | QTL | Position | QTL | Position | QTL | Position | QTL | Position | Associations |
|---|
TLR1
| 8: 30.3 | Â | 6: 55.5 | Â | 6: 60.4 | 7 | 5: 65.3 | 12, 15, 16 | 4: 38.5 | m, g' |
TLR2
| 8: 83.6 | 1 | 17: 3.7 | Â | 17: 4.3 | Â | 3: 83.6 | 12, 13, 17 | 4: 154.8 | a, b, c, d, e |
TLR3
| 15: 58.9 | Â | 26: 18.6 | Â | 27: 17.5 | Â | 8: 46.5 | 12 | 4: 187.2 | Â |
TLR4
| 1: 284.7 | Â | 2: 3.7 | Â | 8: 112.4 | Â | 4: 66.5 | 18 | 9: 119.5 | f, g, h |
TLR5
| 10: 24.9 | Â | 12: 38.7 | Â | 16: 23.6 | 10 | 1: 184.9 | 12, 16, 17, 19 | 1: 221.3 | i |
TLR6
| 8: 30.3 | Â | 6: 55.5 | Â | 6: 60.4 | 7 | 5: 65.3 | 12, 15, 16 | 4: 38.5 | m, g' |
TLR7
| X: 9.3 | Â | X: 12.7 | Â | X: 82.1 | Â | X: 163.7 | Â | X: 12.8 | Â |
TLR8
| X: 9.4 | Â | X: 12.7 | Â | X: 82.0 | Â | X: 163.7 | Â | X: 12.8 | Â |
TLR9
| 13: 39.7 | Â | 19: 52.9 | Â | 22: 49.7 | 9 | 9: 106.1 | 18 | 3: 52.2 | g' |
TLR10
| 8: 30.3 | Â | 6: 55.5 | Â | 6: 60.3 | 7 | n/a: n/a | Â | 4: 38.4 | Â |
CASP8
| 15: 128.6 | Â | Â | Â | 2: 94.0 | Â | 1: 58.8 | 18, 20 | 2: 201.8 | Â |
IRAK-1
| X: 133.9 | Â | Â | Â | X: 23.5 | Â | X: 71.3 | Â | X: 152.9 | f' |
LY96
| 4: 70.7 | Â | 9: 67.8 | Â | 14: 35.0 | 9' | 1: 16.7 | 17 | 8: 75.1 | Â |
MyD88
| 13: 29.0 | Â | 19: 10.8 | Â | 22: 11.7 | 10 | 9: 119.2 | 18, 21 | 3: 38.2 | Â |
TICAM1
| Â | Â | 5: 23.1 | Â | 7: 17.9 | Â | 17: 56.4 | 22 | 19: 4.7 | 11 |
TICAM2
| 2: 120.8 | 2 | Â | Â | 10: 3.9 | Â | 18: 46.7 | 12, 23 | 5: 114.9 | Â |
TIRAP
| 9: 57.0 | Â | 21: 25.6 | Â | 29: 31.2 | Â | 9: 35.0 | 14, 23 | 11: 125.7 | g', j, k, m' |
TOLLIP
| Â | Â | 21: 47.9 | Â | 29: 44.0 | Â | 7: 149.1 | 24 | 11: 1.3 | Â |
TRAF6
| 2: 22.8 | Â | 15: 62.1 | Â | 15: 62.1 | 8 | 2: 101.5 | Â | 11: 36.5 | Â |
IRF3
| 6: 52.8 | 3,4,5, l | 14: 78.4 | 6 | 18: 56.0 | 7' | 7: 52.3 | 13, n | 19: 54.8 | 11 |
- n/a: no functional homologue for TLR10 in mouse,
- QTL studies: 1: Stress induced alteration in number of neutrophils [35], 2: Stress induced leukocyte proliferation [35], 3: Small intestinal Escherichia coli [36], 4,5: Anti 0149 Escherichia coli IgG levels/level response [35], 6: Nematodirus FEC1 Average [37], 7: Clinical mastitis [38], 7': Clinical mastitis [39], 8: General disease resistance [40], 9: Somatic cell score [41], 9': Somatic cell score [42], 10: Trypanosoma congolense tolerance [43], 11: Coxsackie virus B3 sensitivity [44], 12: Leishmania resistance [45], 13: Mycobacterium tuberculosis susceptibility [46], 14: Mycobacterium tuberculosis infection severity [47], 15: Listeria monocytogenes resistance [48], 16: Trypanosoma cruzi infection response [49], 17: Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility [50], 18: Borrelia burgdorferi-associated arthritis [51], 19: Plasmodium berghei malaria resistance [52], 20: Susceptibility/immunity to Salmonella typhimurium antigens [53], 21: Plasmodium chabaudi malaria resistance [54], 22: Angiostrongylus costaricensis nematode susceptibility [55], 23: Protection against vaginal Candida albicans infections [56], 24: Determination of interleukin commitment [57]
- Association studies: a: Mycobacterium sp. [58], b: Mycobacterium leprae [59], c: Urinary tract infections [60], d: Borrelia burgdorferi [61], e: Treponema pallidum [62], f: Gram-negative infections [63], f': Sepsis [64], g: Plasmodium falciparum [65], g': Plasmodium falciparum [66], h: Bacterial vaginosis [67], i: Legionella pneumophila [68], j: Bacteremia [69], k: Pneumococcia sp. [69], l: Small intestinal Escherichia coli [36], m: Mycobacterium tuberculosis [70], m': Mycobacterium tuberculosis [69], n: Listeria monocytogenes [71]
