| |
Pig
|
Sheep
|
Cattle
|
Mouse
|
Human
|
|---|
|
Gene
|
Position
|
QTL
|
Position
|
QTL
|
Position
|
QTL
|
Position
|
QTL
|
Position
|
Associations
|
|---|
|
TLR1
|
8: 30.3
| |
6: 55.5
| |
6: 60.4
|
7
|
5: 65.3
|
12, 15, 16
|
4: 38.5
|
m, g'
|
|
TLR2
|
8: 83.6
|
1
|
17: 3.7
| |
17: 4.3
| |
3: 83.6
|
12, 13, 17
|
4: 154.8
|
a, b, c, d, e
|
|
TLR3
|
15: 58.9
| |
26: 18.6
| |
27: 17.5
| |
8: 46.5
|
12
|
4: 187.2
| |
|
TLR4
|
1: 284.7
| |
2: 3.7
| |
8: 112.4
| |
4: 66.5
|
18
|
9: 119.5
|
f, g, h
|
|
TLR5
|
10: 24.9
| |
12: 38.7
| |
16: 23.6
|
10
|
1: 184.9
|
12, 16, 17, 19
|
1: 221.3
|
i
|
|
TLR6
|
8: 30.3
| |
6: 55.5
| |
6: 60.4
|
7
|
5: 65.3
|
12, 15, 16
|
4: 38.5
|
m, g'
|
|
TLR7
|
X: 9.3
| |
X: 12.7
| |
X: 82.1
| |
X: 163.7
| |
X: 12.8
| |
|
TLR8
|
X: 9.4
| |
X: 12.7
| |
X: 82.0
| |
X: 163.7
| |
X: 12.8
| |
|
TLR9
|
13: 39.7
| |
19: 52.9
| |
22: 49.7
|
9
|
9: 106.1
|
18
|
3: 52.2
|
g'
|
|
TLR10
|
8: 30.3
| |
6: 55.5
| |
6: 60.3
|
7
|
n/a: n/a
| |
4: 38.4
| |
|
CASP8
|
15: 128.6
| | | |
2: 94.0
| |
1: 58.8
|
18, 20
|
2: 201.8
| |
|
IRAK-1
|
X: 133.9
| | | |
X: 23.5
| |
X: 71.3
| |
X: 152.9
|
f'
|
|
LY96
|
4: 70.7
| |
9: 67.8
| |
14: 35.0
|
9'
|
1: 16.7
|
17
|
8: 75.1
| |
|
MyD88
|
13: 29.0
| |
19: 10.8
| |
22: 11.7
|
10
|
9: 119.2
|
18, 21
|
3: 38.2
| |
|
TICAM1
| | |
5: 23.1
| |
7: 17.9
| |
17: 56.4
|
22
|
19: 4.7
|
11
|
|
TICAM2
|
2: 120.8
|
2
| | |
10: 3.9
| |
18: 46.7
|
12, 23
|
5: 114.9
| |
|
TIRAP
|
9: 57.0
| |
21: 25.6
| |
29: 31.2
| |
9: 35.0
|
14, 23
|
11: 125.7
|
g', j, k, m'
|
|
TOLLIP
| | |
21: 47.9
| |
29: 44.0
| |
7: 149.1
|
24
|
11: 1.3
| |
|
TRAF6
|
2: 22.8
| |
15: 62.1
| |
15: 62.1
|
8
|
2: 101.5
| |
11: 36.5
| |
|
IRF3
|
6: 52.8
|
3,4,5, l
|
14: 78.4
|
6
|
18: 56.0
|
7'
|
7: 52.3
|
13, n
|
19: 54.8
|
11
|
- n/a: no functional homologue for TLR10 in mouse,
- QTL studies: 1: Stress induced alteration in number of neutrophils [35], 2: Stress induced leukocyte proliferation [35], 3: Small intestinal Escherichia coli [36], 4,5: Anti 0149 Escherichia coli IgG levels/level response [35], 6: Nematodirus FEC1 Average [37], 7: Clinical mastitis [38], 7': Clinical mastitis [39], 8: General disease resistance [40], 9: Somatic cell score [41], 9': Somatic cell score [42], 10: Trypanosoma congolense tolerance [43], 11: Coxsackie virus B3 sensitivity [44], 12: Leishmania resistance [45], 13: Mycobacterium tuberculosis susceptibility [46], 14: Mycobacterium tuberculosis infection severity [47], 15: Listeria monocytogenes resistance [48], 16: Trypanosoma cruzi infection response [49], 17: Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility [50], 18: Borrelia burgdorferi-associated arthritis [51], 19: Plasmodium berghei malaria resistance [52], 20: Susceptibility/immunity to Salmonella typhimurium antigens [53], 21: Plasmodium chabaudi malaria resistance [54], 22: Angiostrongylus costaricensis nematode susceptibility [55], 23: Protection against vaginal Candida albicans infections [56], 24: Determination of interleukin commitment [57]
- Association studies: a: Mycobacterium sp. [58], b: Mycobacterium leprae [59], c: Urinary tract infections [60], d: Borrelia burgdorferi [61], e: Treponema pallidum [62], f: Gram-negative infections [63], f': Sepsis [64], g: Plasmodium falciparum [65], g': Plasmodium falciparum [66], h: Bacterial vaginosis [67], i: Legionella pneumophila [68], j: Bacteremia [69], k: Pneumococcia sp. [69], l: Small intestinal Escherichia coli [36], m: Mycobacterium tuberculosis [70], m': Mycobacterium tuberculosis [69], n: Listeria monocytogenes [71]
