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Table 3 Comparative localisation of TLR and related signalling molecules

From: Comparative genomics of Toll-like receptor signalling in five species

  Pig Sheep Cattle Mouse Human
Gene Position QTL Position QTL Position QTL Position QTL Position Associations
TLR1 8: 30.3   6: 55.5   6: 60.4 7 5: 65.3 12, 15, 16 4: 38.5 m, g'
TLR2 8: 83.6 1 17: 3.7   17: 4.3   3: 83.6 12, 13, 17 4: 154.8 a, b, c, d, e
TLR3 15: 58.9   26: 18.6   27: 17.5   8: 46.5 12 4: 187.2  
TLR4 1: 284.7   2: 3.7   8: 112.4   4: 66.5 18 9: 119.5 f, g, h
TLR5 10: 24.9   12: 38.7   16: 23.6 10 1: 184.9 12, 16, 17, 19 1: 221.3 i
TLR6 8: 30.3   6: 55.5   6: 60.4 7 5: 65.3 12, 15, 16 4: 38.5 m, g'
TLR7 X: 9.3   X: 12.7   X: 82.1   X: 163.7   X: 12.8  
TLR8 X: 9.4   X: 12.7   X: 82.0   X: 163.7   X: 12.8  
TLR9 13: 39.7   19: 52.9   22: 49.7 9 9: 106.1 18 3: 52.2 g'
TLR10 8: 30.3   6: 55.5   6: 60.3 7 n/a: n/a   4: 38.4  
CASP8 15: 128.6     2: 94.0   1: 58.8 18, 20 2: 201.8  
IRAK-1 X: 133.9     X: 23.5   X: 71.3   X: 152.9 f'
LY96 4: 70.7   9: 67.8   14: 35.0 9' 1: 16.7 17 8: 75.1  
MyD88 13: 29.0   19: 10.8   22: 11.7 10 9: 119.2 18, 21 3: 38.2  
TICAM1    5: 23.1   7: 17.9   17: 56.4 22 19: 4.7 11
TICAM2 2: 120.8 2    10: 3.9   18: 46.7 12, 23 5: 114.9  
TIRAP 9: 57.0   21: 25.6   29: 31.2   9: 35.0 14, 23 11: 125.7 g', j, k, m'
TOLLIP    21: 47.9   29: 44.0   7: 149.1 24 11: 1.3  
TRAF6 2: 22.8   15: 62.1   15: 62.1 8 2: 101.5   11: 36.5  
IRF3 6: 52.8 3,4,5, l 14: 78.4 6 18: 56.0 7' 7: 52.3 13, n 19: 54.8 11
  1. n/a: no functional homologue for TLR10 in mouse,
  2. QTL studies: 1: Stress induced alteration in number of neutrophils [35], 2: Stress induced leukocyte proliferation [35], 3: Small intestinal Escherichia coli [36], 4,5: Anti 0149 Escherichia coli IgG levels/level response [35], 6: Nematodirus FEC1 Average [37], 7: Clinical mastitis [38], 7': Clinical mastitis [39], 8: General disease resistance [40], 9: Somatic cell score [41], 9': Somatic cell score [42], 10: Trypanosoma congolense tolerance [43], 11: Coxsackie virus B3 sensitivity [44], 12: Leishmania resistance [45], 13: Mycobacterium tuberculosis susceptibility [46], 14: Mycobacterium tuberculosis infection severity [47], 15: Listeria monocytogenes resistance [48], 16: Trypanosoma cruzi infection response [49], 17: Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility [50], 18: Borrelia burgdorferi-associated arthritis [51], 19: Plasmodium berghei malaria resistance [52], 20: Susceptibility/immunity to Salmonella typhimurium antigens [53], 21: Plasmodium chabaudi malaria resistance [54], 22: Angiostrongylus costaricensis nematode susceptibility [55], 23: Protection against vaginal Candida albicans infections [56], 24: Determination of interleukin commitment [57]
  3. Association studies: a: Mycobacterium sp. [58], b: Mycobacterium leprae [59], c: Urinary tract infections [60], d: Borrelia burgdorferi [61], e: Treponema pallidum [62], f: Gram-negative infections [63], f': Sepsis [64], g: Plasmodium falciparum [65], g': Plasmodium falciparum [66], h: Bacterial vaginosis [67], i: Legionella pneumophila [68], j: Bacteremia [69], k: Pneumococcia sp. [69], l: Small intestinal Escherichia coli [36], m: Mycobacterium tuberculosis [70], m': Mycobacterium tuberculosis [69], n: Listeria monocytogenes [71]