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Table 1 The network attributes and corresponding P-values for the 24 sub-networks constructed from RNAi hits.

From: A network-based integrative approach to prioritize reliable hits from multiple genome-wide RNAi screens in Drosophila

RNAi screen [Ref] #hits #edges P-value1 P-value2
Store-operated Ca2+ entry [25] 1,122 4,281 2e-05 3e-98
ERK signaling [26] 982 7,050 2e-71 <1e-229
Nuclear import of Smads [27] 683 1,321 0.07 3e-06
Protein secretion and Golgi organization [28] 645 6,597 <1e-229 <1e-229
Hh signaling pathway [29] 306 3,214 <1e-229 <1e-229
Bacterial infection [30] 286 2,803 <1e-229 <1e-229
Growth and viability [31] 281 1,871 <1e-229 <1e-229
Wnt signaling pathway [32] 167 368 5e-51 1e-92
Light-dependent CRY degradation [33] 131 197 1e-28 9e-105
Neural outgrowth genes [34] 128 414 7e-146 3e-145
Chlamydia infection [35] 126 107 2e-07 2e-17
Regulators of NFAT [36] 121 29 0.7 0.002
Multipolar divisions [37] 115 62 0.005 9e-12
Viral replication [38] 104 2,069 <1e-229 <1e-229
JAK/STAT signaling [39] 104 85 4e-09 1e-21
Mycobacterial infection [40] 76 176 1e-129 8e-117
Transcript-specific mRNA export [41] 65 146 6e-141 2e-100
Ca(2+) influx [42] 65 137 3e-123 9e-54
Muscle assembly and maintenance [43] 39 21 5e-11 5e-08
Caspase activation [44] 37 4 0.4 0.2
Mitochondrial and Peroxisomal Fission [45] 22 2 0.3 0.1
Histone pre-mRNA processing [46] 17 4 2e-04 2e-05
E2F repression [47] 15 7 2e-13 1e-39
Orai proteins [48] 15 9 1e-21 1e-30
  1. Results are sorted based on the number of hits in descending order. The P-value1 and P-value2 are calculated by two different randomization strategies, i.e., 1) randomizing nodes and 2) randomizing edges (with fixed node degree) (see Methods for details).