Table 2 Classification, annotation and expression levels of genes, specifically affected by the STAT5 variants.
Specifically affected by BLG/STAT5ca | Â |
|---|---|
Ras small GTPase | Rasd1, Rasd2 |
GTPase activity | Rasd1 Rasd2 GNAO1 |
Rho GAPs | Chn1 |
G-protein | GNAO1 |
G-protein-coupled receptor | Edg3, Adra2c |
Cytoskeleton protein | Tnni1, Cnn1, Rsnl2 |
GEFs | Rapgef3 |
Cytoskeleton rearrangement | Ptn, pip5k1b |
Organization of microtubules | Rsnl2 |
Cell-cell recognition/signaling/adhesion | Msln, ptn, Rapgef3, Adra2c |
Cell migration | Edg3 |
Mammary development | Ebf2, Gli2 |
Immune system/response | Csf2ra, il5ra, Foxji, H2-K1, EDG3 |
Neurons | Elavl3, Wnt8a, Gfra2, Phgdh |
DNA damage response/cell cycle | Prp19 (DDR), Magea2 (inhibits p53 activation) |
Apoptosis inhibition | Cflar |
Tight junction | Mpdz, Gja7 |
Potassium channel | Kcne4 |
JNK signaling | JIP-2, Rapgef3, Mapk8 |
Transcription factor | Max |
Defense response | Klra5, Klra22 |
Ribosome | Rps15a |
Urea cycle | Otc |
Signal transduction | Mapk1, JIP-2, Rapgef3, Mapk8, Gfra2, Adra2c, Rasd1, Rasd2, GNAO1, Chn1, EDG3, Wnt8a, JIP-2 |
Protein phosphates inhibitor activity | PPP1R2P9 |
Regulation of nucleotide and nucleic acid metabolism | Ddx3y |
Bacterial cell wall degradation | lysmd2 |
Regulating hemoglobin oxygen affinity | Bpgm |
Expressed in the early embryo | Pramel6 |
Not associated | Tyrp1, 1700065I17Rik, Serpinb6c, 2010003K11Rik, 4931412G03Rik (Trpd52l3) |
Specifically affected by BLG/STAT5Δ750 |  |
Adm, Mrpplf4, Cyr61 | Angiogenesis |
Cspg2, Itgβ1, Itgβ3, Scgb1a1, Pcdhb5, Rin1, Lana5, Cyr61, Cav2 | Cell adhesion |
Itgβ1, Foxk1, Rnf134, Peg3, Mkrn3 | Progression through cell cycle |
Peg3, Kif5c, Pcdhb5, Ivns1abp, Mkrn3 | Neuron |
Foxk1, Rnf134, Peg3 | Transcription factor activity |
Gdi2, Rin1 | GTPase activator activity |
Tec, Trhr, Oprl, V1ra9, 5930418K15Rik | G-protein-coupled receptor protein signaling pathway |
Adm, Wnt7b, Pcdhb5 | Cell-cell signaling |
Irs4 | Insulin receptor binding |
Orc3l | DNA replication |
Eif2s2 | Translation initiation factor activity |
Cugbp1 | Translation repressor activity |
Cdv3, Cyr61 | Cell proliferation |
Hsd17b1 | Estradiol 17-beta-dehydrogenase activity |
H2-Eb1, Tec, Igbp1b, Nudcd1 | Immune response |
Nudcd1, Mkrn3, Msmb, Cav2, Gnmt, Cryl1 | Cancer-related |
Kif5c | Microtubule-based movement |
Abhd1 | Hydrolase activity |
Klf1 | Chromatin remodeling |
Peg3, Mkrn3 | Apoptosis |
B3galt1 | Transferase activity, transferring glycosyl groups |
Igbp1b | B-cell activation |
Krt2-17, Kif5c | Cytoskeleton organization and biogenesis |
Pdss1 | Isoprenoid biosynthetic process |
Pi4k2b | Phosphotransferase activity, alcohol group as acceptor |
Nol5 | Ribosome biogenesis and assembly |
Fabp5 | PPAR signaling pathway/lipid metabolic process |
Gnmt | Breaks down the protein building block (amino acid) methionine |
4930422J18Rik(SSB-1) | Ubiquitin cycle |
C80171, 1810030O07Rik, Es2el, Pter | Not associated |