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Table 2 List of genes involved in the signal pathways

From: A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor

    

Fold change

Gene symbol

ProbeName

GenBank

Description

Overexpression

Knockdown

Regulation of kinase activity

   RB1

A_23_P204850

NM_000321

Retinoblastoma 1 (including osteosarcoma)

0.74

1.53

   GADD45B

A_23_P142506

NM_015675

Growth arrest and DNA-damage-inducible, beta

1.45

0.68

   PKIA

A_23_P31765

NM_006823

Protein kinase (cAMP-dependent, catalytic) inhibitor alpha

0.68

1.41

   TIZ/ZNF675

A_24_P931755

D70835

TRAF6-inhibitory zinc finger protein

0.71

1.38

   SPRY4

A_24_P269062

NM_030964

Sprouty homolog 4 (Drosophila)

2.12

0.57

   DUSP6

A_23_P139704

NM_001946

Dual specificity phosphatase 6

1.56

0.74

   RGS4

A_23_P200737

BC000737

Regulator of G-protein signalling 4

1.83

0.65

   SPRED2

A_32_P225854

NM_181784

Sprouty-related, EVH1 domain containing 2

1.52

0.72

   NRG1

A_23_P315815

NM_004495

Neuregulin 1

1.51

0.74

   ZAK/MLTK_HUMAN

A_23_P318300

NM_133646

Sterile alpha motif and leucine zipper containing kinase AZK

0.69

1.56

   EDN1

A_23_P214821

NM_001955

Endothelin 1

2.33

0.49

   PRKD3

A_24_P165656

NM_005813

Protein kinase D3

0.74

1.56

   KITLG

A_24_P133253

NM_000899

KIT ligand

0.68

1.51

   C1QTNF6

A_24_P211565

NM_031910

C1q and tumor necrosis factor related protein 6

0.47

1.54

   C5

A_23_P71855

NM_001735

Complement component 5

0.42

2.62

   MAP4K5

A_23_P205646

BC036013

Mitogen-activated protein kinase kinase kinase kinase 5

0.74

1.39

   CCNA1

A_23_P48414

NM_003914

Cyclin A1

2.51

0.54

   CDKN2B

A_24_P360674

NM_078487

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

1.81

0.71

   CKS1B

A_32_P175864

BG205572

CDC28 protein kinase regulatory subunit 1B

1.45

0.64

   SERTAD1

A_23_P218463

NM_013376

SERTA domain containing 1

1.51

0.75

Angiogenesis

   CEACAM1

A_24_P382319

NM_001712

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

0.60

1.78

   COL18A1

A_23_P211212

NM_030582

Collagen, type XVIII, alpha 1

0.74

0.66

   CTGF

A_23_P19663

NM_001901

Connective tissue growth factor

3.88

0.24

   MYH9

A_23_P57497

BC011915

Myosin, heavy polypeptide 9, non-muscle

1.34

0.75

   NRP2

A_24_P50801

AF280546

Neuropilin 2

1.77

0.59

   PLXDC1

A_23_P3911

BC036059

Plexin domain containing 1

0.63

1.38

   VEGF

A_23_P70398

NM_003376

Vascular endothelial growth factor

0.75

1.31

   CXCL12

A_23_P202448

U19495

Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

0.73

1.37

   CYR61

A_23_P46426

Z97068

Cysteine-rich, angiogenic inducer, 61

1.74

0.44

   EDN1

A_23_P214821

NM_001955

Endothelin 1

2.33

0.49

   SEMA5A

A_23_P213415

NM_003966

Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and sh

0.28

2.26

   IL17F

A_23_P167882

NM_052872

Interleukin 17F

1.78

2.01

   RUNX1

A_24_P34155

X90980

Runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)

1.48

0.74

   THBS1

A_23_P206212

X04665

Thrombospondin 1

1.97

0.59

Brain development

   APAF1

A_23_P36611

NM_181861

Apoptotic protease activating factor

0.58

1.36

   ATM

A_23_P35916

NM_000051

Ataxia telangiectasia mutated (includes complementation groups A, C and D)

0.63

1.35

   CXCL12

A_23_P202448

U19495

Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

0.73

1.37

   SEPP1

A_23_P121926

NM_005410

Selenoprotein P, plasma, 1

0.66

1.36

   SMARCA1

A_23_P44244

NM_003069

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

0.43

1.40

   ATRX

A_24_P348660

NM_000489

Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)

0.60

1.49

   NOTCH3

A_32_P42895

A_32_P42895

Notch homolog 3 (Drosophila)

0.68

1.46

   PRKG1

A_23_P136041

NM_006258

Protein kinase, cGMP-dependent, type I

0.43

1.34

   ATP7A

A_23_P217737

NM_000052

ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)

0.48

1.52

   FOXP2

A_24_P16559

AF467257

forkhead box P2

0.67

1.40

   CEP290

A_23_P36865

AB002371

Centrosome protein cep290

0.70

1.43

Response to DNA damage stimulus

   ZAK/NP_598407.1

A_23_P318300

NM_133646

Sterile alpha motif and leucine zipper containing kinase AZK

0.69

1.56

   BRCA1

A_23_P207400

NM_007294

Breast cancer 1, early onset

0.71

1.3

   ATM

A_23_P35916

NM_000051

Ataxia telangiectasia mutated (includes complementation groups A, C and D)

0.63

1.35

   ATRX

A_24_P348660

NM_000489

Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)

0.60

1.49

   BRCA2

A_23_P99452

NM_000059

Breast cancer 2, early onset

0.62

1.3

   BTG2

A_23_P62901

NM_006763

BTG family, member 2

0.72

1.35

   Q6P2G2_HUMAN

A_24_P361457

NM_173627

Hypothetical protein FLJ35220 (FLJ35220)

0.63

1.49

   RBM14

A_23_P161644

NM_032886

RNA-binding motif protein 14

0.62

1.47

   MLH3

A_24_P61520

NM_014381

MutL homolog 3 (E. coli)

0.59

1.45

   N4BP2_HUMAN

A_24_P222114

AK001542

Nedd4 binding protein 2

0.52

1.47

   PMS1

A_23_P40059

NM_000534

PMS1 postmeiotic segregation increased 1 (S. cerevisiae)

0.65

1.34

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BMC Genomics

ISSN: 1471-2164

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