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Table 2 Gene expression signature of T lymphocyte cell cycle exit.

From: Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal

  Probe set Gene symbol Description Fold-change (after IL-2 withdrawal vs. before) Paired design Non-paired design
      Parametric p-value FDR1 Parametric p-value FDR
Up-regulated
1 1555878_at RPS24 ribosomal protein S24 3.21 0.0003 0.30 <0.0001 0.03
2 201471_s_at SQSTM1 sequestosome 1 2.48 0.0002 0.30 0.0004 0.09
3 226831_at NA NA 2.04 0.0004 0.30 <0.0001 <0.01
4 1555446_s_at TMEM1 transmembrane protein 1 2.04 <0.0001 0.30 <0.0001 <0.01
5 218684_at LRRC8D leucine rich repeat containing 8 family, member D 1.72 0.0007 0.30 0.0003 0.09
6 208091_s_at ECOP EGFR-coamplified and overexpressed protein 1.69 0.0006 0.30 <0.0001 0.06
7 244803_at YY1AP1 YY1 associated protein 1 1.66 0.0002 0.30 0.0004 0.09
8 209006_s_at C1orf63 chromosome 1 open reading frame 63 1.65 0.0006 0.30 0.0007 0.10
9 213702_x_at ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.59 <0.0001 0.30 <0.0001 0.02
10 212833_at SLC25A46 solute carrier family 25, member 46 1.58 0.0006 0.30 0.0005 0.10
11 212310_at MIA3 melanoma inhibitory activity family, member 3 1.50 0.0007 0.30 <0.0001 0.03
12 1562612_at ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 1.47 <0.0001 0.309 <0.0001 <0.01
13 230161_at CD99 CD99 molecule 1.45 0.0005 0.30 <0.0001 <0.01
Down-regulated
1 1553101_a_at ALKBH5 alkB, alkylation repair homolog 5 (E. coli) 0.72 0.0003 0.23 0.0009 0.11
2 201968_s_at PGM1 phosphoglucomutase 1 0.64 0.0006 0.22 0.0006 0.10
3 206055_s_at SNRPA1 small nuclear ribonucleoprotein polypeptide 0.62 0.0005 0.22 0.0005 0.10
4 228146_at C17orf51 chromosome 17 open reading frame 51 0.55 0.0007 0.22 0.0007 0.10
5 207339_s_at LTB lymphotoxin beta (TNF superfamily, member 3) 0.54 0.0002 0.22 0.0008 0.11
6 201170_s_at BHLHB2 basic helix-loop-helix domain containing, class B, 2 0.53 <0.0001 0.22 <0.0001 0.04
7 202932_at YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.50 0.0008 0.224 0.0009 0.11
8 206999_at IL12RB2 interleukin 12 receptor, beta 2 0.49 0.0002 0.22 0.0005 0.10
9 201041_s_at DUSP1 dual specificity phosphatase 1 0.44 0.0005 0.21 <0.0001 0.05
10 202081_at IER2 immediate early response 2 0.43 0.0005 0.21 0.0009 0.11
11 227262_at HAPLN3 hyaluronan and proteoglycan link protein 3 0.41 0.0005 0.20 0.0006 0.10
12 218551_at RP5-1077B9.4 invasion inhibitory protein 45 0.41 0.0004 0.20 0.0006 0.10
13 212590_at RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.40 0.0002 0.20 0.0002 0.07
14 226283_at WDR51B WD repeat domain 51B 0.39 0.0004 0.20 <0.0001 0.01
15 219681_s_at RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.38 0.0004 0.20 <0.0001 0.03
16 219255_x_at IL17RB interleukin 17 receptor B 0.38 0.0004 0.20 0.0005 0.10
17 224156_x_at IL17RB interleukin 17 receptor B 0.37 0.0007 0.20 0.0006 0.10
18 210845_s_at PLAUR plasminogen activator, urokinase receptor 0.36 0.0004 0.20 0.0003 0.08
19 214508_x_at CREM cAMP responsive element modulator 0.30 0.0007 0.20 <0.0001 0.05
20 209488_s_at RBPMS RNA binding protein with multiple splicing 0.28 0.0007 0.20 <0.0001 0.05
21 223217_s_at NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.25 0.0008 0.20 0.0005 0.10
22 209193_at PIM1 pim-1 oncogene 0.20 <0.0001 0.20 <0.0001 <0.01
23 225262_at FOSL2 FOS-like antigen 2 0.17 0.0004 0.20 0.0006 0.10
24 227599_at C3orf59 chromosome 3 open reading frame 59 0.17 <0.0001 0.19 <0.0001 <0.01
25 244035_at BCL2 B-cell CLL/lymphoma 2 0.16 0.0008 0.19 0.0009 0.11
26 202859_x_at IL8 interleukin 8 0.15 0.0009 0.19 0.0006 0.10
27 211506_s_at IL8 interleukin 8 0.10 0.0003 0.19 0.0002 0.07
28 203821_at HBEGF heparin-binding EGF-like growth factor 0.06 0.0004 0.19 0.0002 0.07
29 207844_at IL13 interleukin 13 0.05 <0.0001 0.19 0.0007 0.10
30 214637_at OSM oncostatin M 0.05 0.0002 0.18 <0.0001 <0.01
31 203373_at SOCS2 suppressor of cytokine signaling 2 0.04 0.0001 0.17 <0.0001 0.03
32 205266_at LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.04 0.0003 0.17 <0.0001 0.03
33 203372_s_at SOCS2 suppressor of cytokine signaling 2 0.03 0.0002 0.17 <0.0001 0.03
34 208891_at DUSP6 dual specificity phosphatase 6 0.03 0.0002 0.17 <0.0001 <0.01
35 223377_x_at CISH cytokine inducible SH2-containing protein 0.03 <0.0001 0.16 <0.0001 <0.01
36 223961_s_at CISH cytokine inducible SH2-containing protein 0.03 <0.0001 0.14 <0.0001 0.01
37 221223_x_at CISH cytokine inducible SH2-containing protein 0.03 <0.0001 0.13 <0.0001 <0.01
38 208893_s_at DUSP6 dual specificity phosphatase 6 0.02 <0.0001 0.13 <0.0001 <0.01
39 230170_at OSM oncostatin M 0.02 0.0002 0.13 <0.0001 <0.01
40 208892_s_at DUSP6 dual specificity phosphatase 6 0.02 0.0010 0.05 <0.0001 0.03
  1. Common genes identified as significantly changed (p < 0.001) in a paired analysis and in a non-paired block analysis.
  2. 1FDR – False Discovery Rate