Maternal diabetes alters transcriptional programs in the developing embryo

BMC Genomics

Table 3 In vivo function of genes affected in diabetes exposed embryos.

Function	#	GeneSymbol
metabolic/growth defect	15	Ap1g1, Aplp2, Ghr, Grb10, Hmga1, Mapk10, Mbtps1, Mtap2, Nedd4, Ptprs, Scd2, Tnks2, Top2b, Upp1, Zfp385
diabetes	2	Ghr, Hmga1
embryonic	35	Abcb7, Adam10, Agtr2, Ap1g1, Aplp2, Bcl11a, Creb1, Cxadr, Dcx, Efnb2, Epha3, Gad1, Grb10, Hif1a, Il6st, Itgav, Kras, Mbtps1, Ndst1, Nedd4, Nsd1, Ogt, Pdgfra, Ptprs, Pxn, Scd2, Sema3a, Setdb1, Sfrs2, Slc2a1/Glut1AS^a,, Tfrc, Tgfbr1, Top2b, Twsg1, Vcl
cardiovascular	15	Adam10, Agtr2, Cxadr, Dysf, Efnb2, Epha3, Hif1a, Il6st, Itgav, Pdgfra, Pxn, Sema3a, Sfrs2, Tgfbr1, Vcl
neural tube defects	7	Adam 10, Hif1a, Pdgfra, Tfrc, Tgfbr, Twsg1, Vcl

Information was obtained from GO annotations and hand curated with input from MGI and PubMed sources. All results are from knockout models, except for: ^a) Glut 1 antisense transgenic mice. References are provided in Additional file 4.

ISSN: 1471-2164