Interolog detection and filtering. Proteins in similar color belong to the same orthologous group as identified by OrthoMCL. Connecting lines indicate predicted interactions between proteins. First, all possible combinations between proteins in the two orthologous groups are predicted. Second, some connections between proteins do not hold true when considering the genomic features e.g. GO cellular component. The result is the filtered interactome (solid lines), which extended to the predicted interactome using the interactions that did not pass the filters (dashed lines).