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Table 1 Tabulation of S. aureus essential genes by category.

From: Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

Category Number of essential genes in S. aureus Number of S. aureus essential genes with an essential orthologue in B. subtilis Number of B. subtilis essential genes with no essential orthologue in S. aureus
DNA metabolism 27 22 3
DNA replication 16 16 0
DNA packaging and segregation 11 6 3
RNA metabolism 25 14 2
Basic transcription machinery 4 4 0
RNA modification 10 7 2
RNA regulation 11 3 0
Protein synthesis 102 86 7
Ribosomal proteins 49 47 4
tRNA synthetase 22 20 1
tRNA modification 2 2 0
Translation factors 13 10 1
Protein folding 5 2 0
Protein modification 3 0 0
Protein translocation 8 5 1
Cell envelope 66 43 22
Lipids 15 11 0
Phospholipids 4 4 1
Cell wall/amino sugar 3 3 3
Diaminopimelate biosynthesis 0 0 4
Peptidoglycan biosynthesis 17 10 2
Teichoic acid biosynthesis 12 8 0
Cell division 12 7 0
Cell shape 0 0 3
Na/H transporter 0 0 9
Cell envelope – other 3 0 0
Carbon metabolism 20 9 0
Glycolysis 11 9 0
Pentose phosphate 4 0 0
Intermediary metabolism 3 0 0
Regulation 2 0 0
Respiratory pathways 11 4 9
Isoprenoid/Mevalonate biosynthesis 8 1 2
Menaquinone biosynthesis 1 1 7
Thioredoxin 2 2 0
Nucleotides 12 8 2
Purine biosynthesis 3 2 2
Purine metabolism 1 0 0
Purine/Pyrimidine biosynthesis 3 3 0
Pyrimidine biosynthesis 5 3 0
Cofactors 24 13 2
Acetyl CoA/CoA 5 1 0
Folate 6 1 2
NAD biosynthesis 4 4 0
SAM 1 1 0
Fe-sulphate cluster 7 6 0
Riboflavin biosynthesis 1 0 0
Other/unknown 64 14 2
Amino acid transporter 1 0 0
GTP binding 6 6 0
Other 4 3 1
Unknown 53 5 1