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Figure 2 | BMC Genomics

Figure 2

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Figure 2

Verification of microarray data for two genes in which aortic expression was related to aneurysm formation. A) ELISA for aortic osteoprotegerin and transforming growth factor beta-1 (right panel) confirmed microarray expression data (left panel). Gene expression data are presented as boxplots of normalised intensity for Tnfsf11b (OPG) and Tgfb1 (TGFb-1) for each group (aneurysmal mice n = 5, non-aneurysmal mice n = 7, saline controls n = 6). ELISA data from suprarenal AAAs (n = 9) and suprarenal aortas without AAA (n = 9) of ApoE-/- mice infused with angiotensin II. B) Immunohistochemistry confirms OPG localisation to aortic media (inset) and thrombus in suprarenal aortas with aneurysm. Aneurysm resistant and saline control aortas showed minimal OPG staining. Scale bars represent 500 μm, except inset where bar represents 50 μm.

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BMC Genomics

ISSN: 1471-2164

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