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Table 1 Summary of the included studies.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Study Comparison Design Method Mice Genes identified
1 Paired supra and infrarenal aortas Pooled samples Codelink mouse whole genome bioarray (36227 genes) 10 Differentially expressed between AAA prone supra and infrarenal aorta
2 Whole aortas of mice exposed to angiotensin II that did and did not develop aneurysms and saline infused controls Individual mice Illumina mouse sentrix 6 microarray (46,628 genes). 18 Differentially expressed between the 3 groups revealing aneurysm-associated and "protective" genes
3 Suprarenal aortas of mice exposed to angiotensin II that did and did not develop aneurysms Individual mice ELISA and IHC 18* Validate findings from the microarray in study 2 for Tnfrsf11b, Tgfb1, and inflammatory cell markers.
  1. * 10 further mice died and were excluded from this study.