The heat map of estimated temporal relationship between top-ranked 20 genes in each sub-module and temporal relationship between modules. The upper part represents the heat map of temporal relationship from previous time to current time between top ranked 20 genes in each sub-module. The gene pairs associated with strong negative regulation are presented as deep green while the white regions represent gene pairs with strong positive regulation. The lower part shows the temporal relationship between modules and the number on arrow represents regulation coefficient estimated by system model (equation 3 in Methods section). (A) heat shock of 37°C, (B) heat shock of 48°C.