Table 6 Putative candidate genes in QTL regions
QTL region | candidate gene name | description | functional category | example of activity |
|---|---|---|---|---|
1-A | BCL2L13 | BCL2-like 13 (apoptosis facilitator) | apoptosis | regulated by TNFα, pro-inflammatory cytokine |
IL17RA | interleukin 17 receptor A | inflammatory response | receptor of IL17, pro-inflammatory cytokine | |
1-B | TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | inflammatory response | receptor of TNFα, pro-inflammatory cytokine |
1-C | TLR7 | toll-like receptor 7 | inflammatory response, innate immunity | recognizes pathogen-associated molecular patterns |
2-A | GRB10 | growth factor receptor-bound protein 10 | growth | regulates IGF-1 signaling |
IKZF1 | IKAROS family zinc finger 1 (Ikaros) | immune response | triggers CD4/CD8 commitment lineage | |
2-B | ANKRD12 | ankyrin repeat domain 12 | regulated by CXCL12 | |
3-B | GHRL | ghrelin/obestatin preprohormone | growth | regulates GH |
3-C | APOB | apolipoprotein B (including Ag(x) antigen) | lipid transport | principal component of LDL |
6-A | CXCL12 | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | inflammatory response, immune response | activates leukocytes |
6-B | BLNK | B-cell linker | immune response | role in B-cell function and development |
23-A | FABP3 | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | lipid transport | participates in uptake and transport of fatty acids |
C2 | complement component 2 | innate immune response | part of complement system pathway |