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Table 2 Performance test of P2CS

From: P2CS: a two-component system resource for prokaryotic signal transduction research

Species Manually defined TCS proteins P2CS Predicted TCS proteins Sensitivity (%) Specificity (%) Precision (%) Reference
Anaeromyxobacter dehalogenans 2CP-C 174 188 (185+3) 100 99.67 92.55 [15]
Bacillus anthracis str. Ames 102 (94+8) 104 (94+10) 100 99.96 97.9 [18]
Bacillus anthracis str. Sterne 102 103 99.02 99.96 98.06 [18]
Bacillus cereus ATCC 14579 101 (99+2) 102 (99+3) 100 99.98 99.02 [18]
Bacillus cereus ATCC 10987 101 (100+1) 99 (98+1) 98.02 100 100 [18]
Bacillus cereus E33L 107 107 100 100 100 [18]
Bacillus subtilis 70 70 100 100 100 [18]
Bacillus thuringiensis serovar konkukian str. 97-27 109 109 100 100 100 [18]
Escherichia coli str. K-12 substr. MG1655 62 62 (61+1) 100 100 100 [15]
Myxococcus xanthus DK1622 278 (276+2) 283 (281+2) 99.28 99.91 97.53 [15]
Nitrosospira multiformis ATCC 25196 chromosome 1 62 59 93.55 99.96 98.31 [19]
Pseudomonas syringae pv. syringae B728a 142 143 97.89 99.92 97.2 [11]
Pseudomonas syringae pv. tomato str. DC3000 143 (140+3) 144 (139+5) 97.2 99.92 96.53 [11]
Pseudomonas syringae pv. phaseolicola 1448A 139 (137+2) 141 (138+3) 97.84 99.87 96.45 [11]
Sorangium cellulosum So ce56 267 273 98.88 99.92 96.70 [15]
Streptomyces coelicolor A3(2) 164 187 99.39 99.68 87.17 [17]
Xanthomonas campestris pv. campestris ATCC 33913 106 110 100 99.9 96.36 [20]
X. campestris pv. campestris 8004 106 110 100 99.9 96.36 [20]
X. axonopodis pv. citri 306 114 120 100 99.86 95 [20]
X. campestris pv. vesicatoria 85-10 121 126 100 99.86 95 [20]
X. oryzae pv. oryzae KACC10331 92 (91+1) 96 (95+1) 100 99.9 95.83 [20]
X. oryzae pv. oryzae MAFF 311018 93 95 100 99.95 97.89 [20]
  1. Comparison to manually detected TCS proteins (numbers in parentheses are the details of predicted and mis-predicted TCS proteins). Parameters calculation: Sensitivity = TP/TP+TN, Specificity = TN/TN+FP, Precision = TP/TP+FP.
  2. TP. True positive, TN. True negative, FP. False positive, FN. False negative.