Source of Variation in kME

kMEblack, Total Prop Var Explained = 8.3%

kMEblue, Total Prop Var Explained = 4.2%


Source

Degrees Of Freedom

Sums of Sq

Prop. Of Total Var

pvalue (F test)

Sums of Sq

Prop. Of Total Var

pvalue (Ftest)


Histone Trimethylation (K4, K27, K4&K27, none)

3

170.91

0.067

< 2.2E16

30.49

0.034

< 2.2E16

cMyc Complex

1

39.21

0.015

< 2.2E16

1.48

0.002

2.6E04

Oct4 Complex

1

8.62

0.003

8.0E08

0.79

0.001

7.5E03

CPG class (HCP, ICP, LCP)

2

4.56

0.002

4.9E04

4.71

0.005

6.0E10

PcG Bound

1

0.88

0.000

8.7E02

0.19

0.000

1.9E01

CpG Methylated

1

0.04

0.000

7.1E01

0.58

0.001

2.2E02

Residual Error

7846

2353.8

0.917
 
868.36

0.958
 
Total Variation

7855

2567.11
  
906.6
  
 This analysis of variance table reports which epigenetic variables and TF binding data have a significant effect on (columns on the left hand side) and (columns on the right hand side). For each variable (source of variation), the columns report the degrees of freedom, the sums of squares, the proportion of total variance explained by the variable and the corresponding Ftest pvalue. Note that histone trimethylation status is the most significant source of variation for both and .