Continental decay of linkage disequilibrium. (A) Mean r2 between all possible SNP pairs within each gene region with MAF greater than 0.05 is plotted at the midpoint of each distance class. The X-axis is not to scale. (B) The proportion of SNP pairs with r2 greater than 0.8 is plotted at the midpoint of each distance class. Vertical lines represent 95% confidence intervals. The X-axis is not to scale. Continental regions are abbreviated as follows: Sub-Saharan Africa (SSAFR; including Bantu, Biaka Pygmies, Mandenka, Mbuti Pygmies, San, and Yoruba), Middle East-North Africa (MENA; including Bedouin, Druze, Mozabite, and Palestinian), Europe (EUR; including Adygei, Basque, French, North Italy, Orcadian, Russian, and Sardinian), Central South Asia (CSASIA; including Balochi, Brahui, Burusho, Hazara, Kalash, Makrani, North West China, Pathan, and Sindhi), East Asia (EASIA; including Cambodian, Han, Japanese, North East China, South China, and Yakut), Oceania (OCE; including NAN Melanesian and Papuan) and America (AME; including Colombian, Karitiana, Maya, Pima, and Surui).