Figure 1

Continental decay of linkage disequilibrium. (A) Mean r² between all possible SNP pairs within each gene region with MAF greater than 0.05 is plotted at the midpoint of each distance class. The X-axis is not to scale. (B) The proportion of SNP pairs with r² greater than 0.8 is plotted at the midpoint of each distance class. Vertical lines represent 95% confidence intervals. The X-axis is not to scale. Continental regions are abbreviated as follows: Sub-Saharan Africa (SSAFR; including Bantu, Biaka Pygmies, Mandenka, Mbuti Pygmies, San, and Yoruba), Middle East-North Africa (MENA; including Bedouin, Druze, Mozabite, and Palestinian), Europe (EUR; including Adygei, Basque, French, North Italy, Orcadian, Russian, and Sardinian), Central South Asia (CSASIA; including Balochi, Brahui, Burusho, Hazara, Kalash, Makrani, North West China, Pathan, and Sindhi), East Asia (EASIA; including Cambodian, Han, Japanese, North East China, South China, and Yakut), Oceania (OCE; including NAN Melanesian and Papuan) and America (AME; including Colombian, Karitiana, Maya, Pima, and Surui).