Circular map of S. mutans strain NN2025. The outer circle shows the scale (bp). From outside, rings 1 and 2 show the coding sequence (ORF) by strands (ring 1, clockwise; ring 2, counterclockwise). The predicted ORFs are distinguished by different colors in the BLAST analysis against the database (see Methods)(indicated as "BLAST classification"). Rings 3 and 4 show the ORF by different colors in the COG classification (indicated as "COG classification"). Ring 5 shows the location of transposase ORFs (including fragment), insertion sequence, and CRISPR associated ORFs. Rings 6 and 7 show the transfer RNA and ribosomal RNA genes identified in the genome. Rings 8 and 9 show the G + C content and GC skew, respectively. The red arrowheads indicate the origin of DNA replication (ori) and the putative region of replication terminus (ter).