Table 1 Panel of genes targeted by siRNA
siRNA | Affymetrix Transcript ID | Refseq ID | Gene description | Relevance to IFNγ response |
|---|---|---|---|---|
Casp4 | 6986649 | NM_007609 | Caspase 4, apoptosis-related cysteine peptidase | pro-apoptotic, IFNγ induced |
Ifi47 | 6780707 | NM_010999 | Interferon gamma inducible protein 47 | IFNγ inducible protein |
Ifnb1 | 6923147 | NM_010510 | Interferon beta 1, fibroblast | IFNγ induced, regulates immune signalling |
Irf3 | 6960326 | NM_016849 | Interferon regulatory factor 3 | virus-induced transcription factor, activates IFNα, & IFNβ |
Irf5 | 6945011 | NM_012057 | Interferon regulatory factor 5 | IFNγ induced, transcription factor, activates IFNα, IFNβ and plays a role in antiviral immunity & apoptosis |
Lyn | 6911337 | NM_001111096 | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | tyrosine kinase activity |
Nfkb2 | 6870063 | NM_019408 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 | DNA-binding sub-unit of NFkB transcription factor complex, regulates immune signalling |
Sod2 | 6858344 | NM_013671 | Superoxide dismutase 2, mitochondrial | role in mitochondrial oxidative phosphorylation |
Stat1 | 6749376 | NM_009283 | Signal transducer and activator of transcription 1 | IFNγ-induced transcription factor, modulates IFN responses through signal transduction |
Stat2 | 6771641 | NM_019963 | Signal transducer and activator of transcription 2 | transcription factor, modulates IFN responses through signal transduction |
Traf1 | 6886021 | NM_009421 | Tnf receptor-associated factor 1 | mediates anti-apoptotic signals from TNF receptors |