Table 1 Summary of protein alterations

1

*Q5T2P8

Annexin A8-like protein 1

37086

5.45

221

13

-3.09 ± 0.24

8

2

P13928

Annexin A8

36842

5.56

269

11

-2.98 ± 0.26

8

3

Q01105

Protein SET

33469

4.23

107

5

5.89 ± 0.52

6

5

Q99497

Protein DJ-1

20,050

6.33

187

5

3.22 ± 0.43

8

4

P52907

F-actin-capping protein subunit alpha-1

32902

5.45

118

6

2.23 ± 0.31

6

Q13765

Nascent polypeptide-associated complex subunit alpha

23370

4.52

451

10

4.37 ± 0.51

8

7

*P24534

Elongation factor 1-beta

24748

4.5

45

1

2.42 ± 0.3

8

8

*P02533

Keratin, type I cytoskeletal 14

51589

5.09

432

17

4.32 ± 0.56

8

9

P09493

Tropomyosin alpha-1 chain

32746

4.69

162

15

6.27 ± 0.38

8

10

P08107

Heat shock 70 kDa protein 1

70009

5.48

234

8

2.33 ± 0.28

8

11

*P07910

Heterogeneous nuclear ribonucleoproteins C1/C2

33650

4.95

140

9

2.95 ± 0.35

6

12

P10809

60 kDa heat shock protein, mitochondrial precursor

61016

5.7

103

7

-4.32 ± 0.58

10

13

P12004

Proliferating cell nuclear antigen

28750

4.57

113

4

7.95 ± 0.38

12

14

P40261

Nicotinamide N-methyltransferase

30011

5.56

59

10

-4.06 ± 0.58

8

15

Q9UL46

PA28 b

27515

5.44

759

28

5.88 ± 0.68

12

16

P52566

Rho GDP-dissociation inhibitor 2

23031

5.1

248

11

3.14 ± 0.28

12

17

* P02679

Fibrinogen gamma chain precursor

51479

5.37

326

18

-3.05 ± 0.42

8

18

P52565

Rho GDP-dissociation inhibitor 1

23193

5.02

211

9

3.44 ± 0.32

12

19

* P05112

Interleukin-4 precursor

17481

9.17

81

1

4.12 ± 0.62

4

20

*P68363

Tubulin alpha-1B chain

50120

4.94

325

16

3.86 ± 0.31

10

21

P05388

60S acidic ribosomal protein P0

34252

5.71

68

6

5.24 ± 0.71

6

22

Q07021

Complement component 1 Q

31742

4.74

309

6

2.12 ± 0.49

8

23

*P02675

Fibrinogen beta chain precursor

56577

8.54

236

18

13.65 ± 1.44

8

24

*P01009

Alpha-1-antitrypsin precursor

46707

5.37

99

2

4.22 ± 0.65

4

25

P09936

Ubiquitin carboxyl-terminal hydrolase isozyme L1

25151

5.33

326

22

11.5 ± 0.84

4

26

P09211

Glutathione S-transferase P

23341

5.43

468

16

5.44 ± 0.24

12

27

P07437

Tubulin beta chain

50095

4.78

197

12

5.67 ± 1.02

10

28

P14618

Pyruvate kinase isozymes M1/M2

58470

7.96

285

18

5.22 ± 0.29

12

29

Q06323

PA28 a

28705

5.78

147

9

4.44 ± 0.25

12

30

P04792

heat shock 27 kDa protein 1

22768

5.98

565

42

5.56 ± 0.37

10

32

P30048

peroxiredoxin 3

27675

7.67

367

28

3.04 ± 0.4

10

31

*P11142

Heat shock cognate 71 kDa protein

70854

5.37

134

7

5.26 ± 0.79

8

33

Q13162

Peroxiredoxin-4

30521

5.86

95

8

4.74 ± 0.22

12

34

P36952

Serpin B5 precursor

42111

5.72

324

19

5.26 ± 0.47

12

35

Q15019

Septin-2

41461

6.15

191

6

3.88 ± 0.65

8

36

Q01469

Fatty acid-binding protein, epidermal

15155

6.6

41

3

6.24 ± 0.25

12

37

*P19013

Keratin, type II cytoskeletal 4

57649

6.25

1023

28

3.12 ± 0.70

4

38

P60709

Actin, cytoplasmic 1

42052

5.29

806

28

5.88 ± 1.02

6

39

Q969H8

Uncharacterized protein C19orf10

18897

6.2

167

11

3.23 ± 0.56

8

40

P47929

Galectin-7

15066

7.03

730

22

6.44 ± 0.26

12

41

* P06733

Alpha-enolase

47139

7.01

1000

27

4.33 ± 0.49

8

42

P60903

Protein S100-A10

11196

6.82

149

18

5.45 ± 0.62

6

43

P62937

Peptidyl-prolyl cis-trans isomerase A

18229

7.68

2056

75

5.68 ± 0.85

6

44

P23528

Cofilin-1

18491

8.22

1677

35

3.11 ± 0.42

8

45

*P22392

Nucleoside diphosphate kinase B

17287

8.52

235

20

4.44 ± 0.23

12

46

Q01995

Transgelin

22596

8.87

238

16

3.28 ± 0.19

12

47

P01834

Ig kappa chain C region

11602

5.58

228

24

3.44 ± 0.65

10

48

P31949

Protein S100-A11

10173

6.56

185

8

5.56 ± 0.75

8

49

P62736

Actin, aortic smooth muscle

41982

5.23

119

6

3.67 ± 0.55

8

50

Q64133

Amine oxidase [flavin-containing] A

60157

7.94

111

1

7.56 ± 0.8

6

51

P47755

F-actin-capping protein subunit alpha-2

32929

5.57

119

11

3.24 ± 0.45

8

52

Q96A32

Myosin regulatory light chain 2, skeletal muscle isoform

19116

4.91

517

33

5.73 ± 0.35

12

53

*P02743

Serum amyloid P-component

25485

6.1

140

5

-2.34 ± 0.45

6

54

P02511

Alpha-crystallin B chain

20146

6.76

874

34

-9.5 ± 1.05

10

55

P61088

Ubiquitin-conjugating enzyme E2 N

17184

6.1

3

86

-3.23 ± 0.45

10

56

P08758

Annexin A5

35914

4.94

496

10

-5.74 ± 0.28

12

57

P62942

FK506-binding protein 1A

11943

7.88

51

2

-2.56 ± 0.45

12

58

P68871

Hemoglobin subunit beta

16102

6.75

996

45

-2.02 ± 0.52

8

59

Q14152

Eukaryotic translation initiation factor 3 subunit I

36479

5.38

190

15

-2.96 ± 0.47

10

60

P06702

Protein S100-A9

13234

5.71

548

23

-6.42 ± 0.58

12

61

P04083

Annexin A1

38690

6.57

2528

60

-5.03 ± 0.28

12

62

P55083

Microfibril-associated glycoprotein 4

28972

5.38

95

1

-3.69 ± 0.55

8

63

P40925

Malate dehydrogenase cytoplasmic

36,403

6.91

4

86

-2.87 ± 0.62

8

64

P27482

Calmodulin-like protein 3

16937

4.3

1562

55

-4.22 ± 0.35

10

65

* P61158

Actin-related protein 3

47341

5.61

93

9

-2.14 ± 0.45

8

66

*P02768

Serum albumin precursor

71317

5.92

856

52

-7.67 ± 0.85

10

67

P05109

Protein S100-A8

10828

6.51

136

13

-3.34 ± 0.55

12

68

*P05976

Myosin light chain 1, skeletal muscle isoform

21132

4.97

881

49

-13.5 ± 0.85

12

69

P30086

Phosphatidylethanolamine-binding protein 1

21044

7.01

210

5

-3.78 ± 0.65

6

70

P11177

Pyruvate dehydrogenase E1 component subunit beta,

39208

6.2

64

5

-5.35 ± 0.25

12

71

P31151

Protein S100-A7

11564

6.28

131

7

-6.23 ± 0.44

12

72

Q96FQ6

Protein S100-A16

11794

6.28

68

4

-7.14 ± 0.86

8

73

P49773

Histidine triad nucleotide-binding protein 1

13793

6.43

40

3

-3.23 ± 0.52

8

74

P69905

Hemoglobin subunit alpha

15305

8.72

769

43

-7.68 ± 1.04

8

75

P04080

Cystatin-B

11133

6.96

378

28

-3.89 ± 0.18

12

76

P07195

L-lactate dehydrogenase B chain

36615

5.71

246

12

-2.69 ± 0.55

6

77

P02144

Myoglobin

17173

7.14

2284

53

-19.22 ± 1.38

12

78

O00299

Chloride intracellular channel protein

26906

5.09

405

16

-2.23 ± 0.48

6

79

P07737

Profilin-1

15216

8.44

1252

53

-5.69 ± 0.35

12

80

O95994

Anterior gradient protein 2 homolog

19967

9.03

292

10

-2.87 ± 0.52

8

81

*P62988

Ubiquitin

18560

6.56

112

5

-5.22 ± 0.43

6

82

P45378

Troponin T, fast skeletal muscle

31805

5.71

233

10

-2.99 ± 0.45

8

83

P12429

Annexin A3

36353

5.63

169

10

-4.41 ± 0.28

12

84

P09525

Annexin A4

35860

5.84

694

20

-2.88 ± 0.56

8

85

P35232

Prohibitin

29843

5.57

214

14

-3.24 ± 0.45

8