From: Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers
TCPOBOP + normal chow diet | Vehicle + cholesterol diet | TCPOBOP + cholesterol diet | |||||
---|---|---|---|---|---|---|---|
Gene Symbol | Gene Description | Log2 ratio | p-value | Log2 ratio | p-value | Log2 ratio | p-value |
Carbohydrate metabolism | |||||||
Pck1 | Phosphoenolpyruvate carboxykinase 1, cytosolic | -0.47 | 0.042 | nc | nc | -0.39 | 0.039 |
Pdhb | Pyruvate dehydrogenase (lipoamide) beta | 0.61 | 0.000 | 0.33 | 0.005 | 0.43 | 0.014 |
G6Pase | Glucose-6-phosphatase catalytic | nc | nc | 1.00 | 0.005 | -1.26 | 0.000 |
Gapdh | Glyceraldehyde-3-phosphate dehydrogenase | nc | nc | 0.49 | 0.016 | nc | nc |
Fatty acid metabolism | |||||||
Cpt1a | Carnitine palmitoyltransferase 1a, liver | -0.81 | 0.000 | nc | nc | -0.38 | 0.004 |
Hmgcl | 3-hydroxy-3-methylglutaryl-Coenzyme A lyase | 0.31 | 0.008 | -0.53 | 0.001 | 0.64 | 0.003 |
Fasn | Fatty acid synthase | 0.58 | 0.007 | nc | nc | nc | nc |
Scd1 | Stearoyl-Coenzyme A desaturase 1 | nc | nc | 1.40 | 0.004 | -1.32 | 0.018 |
Cyp4f14 | Cytochrome P450, 4f14 | nc | nc | 0.98 | 0.000 | -0.72 | 0.000 |
Transcription regulators | |||||||
Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | -1.17 | 0.000 | nc | nc | -0.99 | 0.000 |
Sirt1 | Sirtuin 1, silent mating type information regulation 2, homolog 1 | -0.40 | 0.010 | nc | nc | nc | nc |
Foxa2 | Forkhead box A2 | -0.22 | 0.049 | nc | nc | nc | nc |
Mlxipl | MLX interacting protein-like, old Wbscr14 or Chrebp | 0.94 | 0.000 | 1.05 | 0.000 | 0.32 | 0.047 |
Crem | CAMP responsive element modulator | nc | nc | 0.35 | 0.002 | -0.35 | 0.016 |
Ppara | Peroxisome proliferator activated receptor alpha | -0.84 | 0.000 | 0.53 | 0.035 | -0.93 | 0.000 |
Pparg | Peroxisome proliferator activated receptor gamma | -0.83 | 0.005 | nc | nc | nc | nc |
Transporters | |||||||
Slc2a4 | Solute carrier family 2 (facilitated glucose transporter), member 4 | -0.43 | 0.000 | nc | nc | nc | nc |
Slc2a1 | Solute carrier family 2 (facilitated glucose transporter), member 1 | 0.37 | 0.001 | nc | nc | 0.32 | 0.011 |
Cell signaling | |||||||
Ppp1r3c | Protein phosphatase 1, regulatory (inhibitor) subunit 3C | -3.47 | 0.000 | -0.39 | 0.015 | -2.64 | 0.000 |
Igf1 | Insulin-like growth factor 1 | -1.08 | 0.000 | 0.69 | 0.000 | -1.37 | 0.000 |
Adipor2 | Adiponectin receptor 2 | -0.85 | 0.000 | nc | nc | -0.80 | 0.001 |