Figure 2
From: GEM-TREND: a web tool for gene expression data mining toward relevant network discovery
The method for P-value calculation. (1) Calculate the numbers of up- and down-regulated genes that overlap between Q and a reference profile R; let the numbers be u' (≤ u) and v' (≤ v), respectively. (2) Select u' and v' genes sequentially and randomly from the n genes of R without replacement, and construct a random signature; (3) Calculate the similarity score between R and the random signature; (4) Generated a total of 10,000 random scores by repeating steps 2 and 3. (5) The p-value associated with the similarity score (query score) between query Q and reference R is the proportion of random scores that are no less than the observed similarity score (query score).