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Table 5 Ingenuity Pathways Analysis: Top Bio Functions - Physiological System Development and Function

From: Fibroblasts from patients with Diamond-Blackfan anaemia show abnormal expression of genes involved in protein synthesis, amino acid metabolism and cancer

Category

P-value*

Molecules

N°

Connective Tissue Development and Function

2.14E-04 to 3.06E-02

RPL22, ICAM1, LIF, KLF10, BMP2, MMP14, METTL8, HAX1, TNFAIP3, NFKB1, MSX2, EIF4EBP1, PTEN, PGF, LIMK1, EDN1, CHST3, FOSL2, SSBP3, MMP1 (includes EG:4312), SRC, PXN, MITF, BGN, JUNB, IRAK3, CEBPB, NFKB2, IGF2R, NDN, NOV, RUNX1, PLAU

33

Embryonic Development

2.14E-04 to 3.06E-02

LIF, ICAM1, BMP2, EXT1, NUP50, MSX2, PTEN, NR4A3, NFKBIA, RASSF1, EDN1, POSTN, FOSL2, SRC, PXN, MITF, FGFR1, THRA, L1CAM, JUNB, CEBPB, AFF1, BTG2, RBPJ, IFT52, PLAU

26

Skeletal and Muscular System Development and Function

2.14E-04 to 3.06E-02

MSC, VAMP5, LIF, MMP14, BMP2, KLF10, METTL8, FKBP1A, EXT1, NFKB1, COMP, MSX2, PGF, PTEN, SATB2, NFKBIA, EDN1, CDON, FOXO3, CHST3, POSTN, FOSL2, ACTC1, SSBP3, CACNA1G, SRC, NOX4, BMP2K (includes EG:55589), NAB1, SGCG, MITF, FGFR1, BGN, ADCY3, THRA, NFKB2, IRAK3, JUNB, SMA4, RBPJ, PLAU, RUNX1

42

Tissue Morphology

2.14E-04 to 3.06E-02

ICAM1, LIF, BMP2, NFKB1, MSX2, ABCA1, PGF, PTEN, EIF4EBP1, CASP9, NFKBIA, EDN1, CTSS, PHGDH, FOSL2, SSBP3, SRC, RELB, BGN, ZIC1, APAF1, L1CAM, THRA, JUNB, NFKB2, CEBPB, OGG1, AFF1, CCND2, RBPJ, CYLD, PLAU, ATP2B4

33

Respiratory System Development and Function

1.44E-03 to 3.06E-02

SRC, NFKBIA, CCND2, COX11, EDN1, MAN2A1, MAFB, ABCA1, NDN, PTEN

10

  1. *Fischer's exact test was used to calculate a p-value determining the probability that each biological function assigned to that data set is due to chance alone.
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BMC Genomics

ISSN: 1471-2164

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