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Table 3 Ingenuity analysis of the genes targeted by top eleven screened miRNAs

From: Identification and characterization of miRNAs expressed in the bovine ovary

miRNAs Functions and disease categories enriched with the selected miRNA targets Canonical Pathways enriched with the selected miRNA targets
Let-7b Tissue morphology, cellular growth and proliferation, endocrine system disorders IGF-1 signaling, hepatic fibrosis/hepatic stellate cell activation
mir-15b cell death, connective tissue development and function, cell cycle p53 signaling, PPAR╬▒/RXR activation
mir-18a Cell cycles, cellular function, endocrine system development Cell cycle: G1/S checkpoint regulation,
TGF-╬▓ signaling
mir-29a Reproductive system development and function, organ development, endocrine system development Ephrin receptor signaling
Aminophosphonate metabolism
mir-101 Endocrine system development, lipid metabolism, small molecule biochemistry C21-steroid hormone metabolism, Androgen and estrogen metabolism
mir-125b Inflammatory response, cell cycle, cellular function and maintenance LPS/IL-1 Mediated inhibition of RXR function, LXR/RXR activation
mir-126 Cellular movement, Endocrine system disorders, cell mediated immune response Pro-apoptosis, PXR/PXR activation
mir-143 Cellular growth and proliferation, DNA replication, recombination and repair, gene expression G1/S transition of the cell cycle, p53 signaling
mir-145 Reproductive system diseases, reproductive system development and function, cell death BMP signaling pathway, VEGF signaling
mir-199a Cellular development, cell death, cellular growth and proliferation Cell cycle: G2/M DNA damage checkpoint regulation, p38 MAPK signaling
mir-222 Cellular development, reproductive system development and function, cell death IGF-1 signaling, Axonal guidance signaling
  1. Eleven top miRNAs targeting highest number of genes from our screened and filtered all predicted targets and their top Gene Ontology categories and pathways based on Fisher' Exact P-value (< 0.05) are presented in the table. For detail figures see additional file 3.