Osteopontin: an early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis

Table 3 Association of the SNPs in the SPP1 gene with EBVs for SCS.

	Average allelic substitution effect (in EBV units of score)^a
	SCS			SCS1			SCS2			SCS3
DNA Polymorphisms				Average allele effect ± SE ( P value)
SPP1c.-1301G>A	0.047	± 0.030	(0.121)	0.033	± 0.030	(0.280)	0.047	± 0.034	(0.165)	0.035	± 0.038	(0.362)
SPP1c.-1251C>T	0.117	± 0.047	(0.014)	0.097	± 0.046	(0.035)	0.118	± 0.052	(0.023)	0.112	± 0.059	(0.056)
SPP1c.-430G>A	- 0.117	± 0.047	(0.014)	- 0.097	± 0.046	(0.035)	- 0.118	± 0.052	(0.023)	- 0.112	± 0.059	(0.056)
SPP1c.40A>C*	- 0.102	± 0.045	(0.023)	- 0.068	± 0.044	(0.121)	- 0.103	± 0.049	(0.038)	- 0.112	± 0.056	(0.045)

^a EBVs are calculated for the respective lactation: over all (SCS), first (SCS1), second (SCS2), and third (SCS3) lactations

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