Table 1 Gene targets of tunicamycin identified in the tiling array experiment.

purine base metabolic process

knockout sensitive to tunicamycin [23]

protein amino acid N-linked glycosylation and others

known target of tunicamycin [15–17]

endoplasmic reticulum unfolded protein response and others

knockout sensitive [21–23], overexpressor resistant [21] to tunicamycin

ER to Golgi vesicle-mediated transport and others

involved in ER to Golgi vesicle-mediated transport [25]

unknown

knockout sensitive to tunicamycin [21]

protein insertion into ER membrane and others

knockout sensitive to tunicamycin [24]

specific RNA polymerase II transcription factor activity and others

knockout sensitive to tunicamycin [21, 23]

endoplasmic reticulum unfolded protein response and others

knockout sensitive to tunicamycin [21, 23]

unknown

unknown

unknown

likely deletes HAC1 promoter [19]

unknown

interacts with kinases Ptk2, Tpk1 [30]

protein import into nucleus and others

interacts with Ulp1, regulating ubiquitination [31]

ER to Golgi vesicle-mediated transport and others

involved in ER to Golgi vesicle-mediated transport [26]

ER to Golgi vesicle-mediated transport and others

interacts with Bre5, Hsc82, Hsp92 [31–33] which are involved in protein processing

transcription from RNA polymerase III promoter

interacts with Mms1, Shp1, Ubi4, regulating ubiquitination [34, 35]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway and others

involved in ubiquitin-dependent protein catabolism [36]