Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies)

Table 1 Insecticidal activity of temephos with and without enzyme inhibitors on larvae of Aedes aegypti Vauclin and Bora-Bora strains

Strain	Enzyme inhibitor	Slope (± SE)	LC₅₀ (μg/L) (95% CI)	LC₉₅ (μg/L) (95% CI)	RR₅₀ (95% CI)	RR₉₅ (95% CI)	SR₅₀ (95% CI)	SR₉₅ (95% CI)
	-	8.49 (0.45)	3.7 (3.6-3.8)	5.7 (5.5-6)	-	-	-	-
Bora-Bora	PBO	8.28 (0.67)	4.2 (4-4.4)	6.7 (6.4-7)	-	-	0.87 (0.74-1.03)	0.87 (0.74-1.03)
	DEF	8.13 (0.44)	3.3 (3.2-3.4)	5.3 (5.1-5.6)	-	-	1.10 (0.98-1.24)	1.10 (0.98-1.24)
	DMC	11.16 (0.54)	4.3 (4.2-4.4)	6.0 (5.8-6.2)	-	-	0.86 (0.79-0.94)	0.96 (0.81-1.14)
	-	2.08	160	1000	44	175	-	-
		(0.08)	(150-180)	(870-1180)	(40-48)	(150-205)
	PBO	3.60	140	400	33	60	1.16	2.52
Vauclin		(0.24)	(130-150)	(360-450)	(29-38)	(51-71)	(1.05-1.29)	(2.16-2.95)
	DEF	3.00	68	240	21	44	2.37	4.27
		(0.16)	(64-72)	(210-270)	(18-22)	(38-52)	(2.18-2.57)	(3.64-5)
	DMC	2.05	103	650	24	109	1.57	1.57
		(0.11)	(92-110)	(560-790)	(22-27)	(92-129)	(1.39-1.79)	(1.39-1.79)

Resistant ratios RR₅₀ and RR₉₅ were obtained by calculating the ratio between the LC₅₀ and LC₉₅ between Vauclin and Bora-Bora strains; Synergism ratios SR₅₀ and SR₉₅ were obtained by calculating the ratio between LC₅₀ and LC₉₅ with and without enzyme inhibitor. (CI): Confidence Interval. Significant RR and SR are shown in bold.

ISSN: 1471-2164