Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens

Table 1 Pathogen strains in profile searches

Phylum or Class	Strain	Abbreviation
Firmicutes	Bacillus anthracis str. Ames Ancestor	Ba
Alphaproteobacteria	Brucella melitensis 16M	Bme
Alphaproteobacteria	Rickettsia prowazekii str. Madrid E	Rp
Betaproteobacteria	Burkholderia mallei ATCC 23344	Bma
Betaproteobacteria	Burkholderia pseudomallei K96243	Bp
Gammaproteobacteria	Coxiella burnetii RSA 493	Cb
Gammaproteobacteria	Escherichia coli O157:H7	Ec
Gammaproteobacteria	Francisella tularensis subsp. tularensis Schu 4	Ft
Gammaproteobacteria	Salmonella enterica serovar Typhi Ty2	Se
Gammaproteobacteria	Salmonella typhimurium LT2	St
Gammaproteobacteria	Shigella flexneri 2a str. 301	Sf
Gammaproteobacteria	Vibrio cholerae O1 biovar eltor str. N16961	Vc
Gammaproteobacteria	Yersinia pestis CO92	Yp
Gammaproteobacteria	Yersinia pseudotuberuculosis IP32953	Yptb

Strains of select agents (CDC category A and B bacteria) assigned to the target group in profile searches. Genomes sequences from some select agents were unavailable at the time (Clostridium botulinum and Chlamydia psittaci) and the toxin-producing strains of Staphylococcus aureus and Clostridium perfringens were excluded from the searches. Where multiple strains had been sequenced (such as for Bacillus anthracis and Yersinia pestis), a single representative strain was selected so that results were not skewed to favor species with multiple entries.

ISSN: 1471-2164